TcIL3000_10_10990

bifunctional aminoacyl-tRNA synthetase, putative, prolyl-tRNA synthetase, putative

Trypanosoma congolense IL3000 OG6: OG6_100749 OG7: OG7_0002333 224 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 224 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
TcIL3000_10_10910 hypothetical protein, conserved	—	OG6 TCSYLVIO_006238 ↔ TCSYLVIO_006246 OG6 LdBPK_181230.1 ↔ LdBPK_181300.1 OG7 LdBPK_181230.1 ↔ LdBPK_181300.1 OG7 TCSYLVIO_006238 ↔ TCSYLVIO_006246	Both
TcIL3000_10_11660 hypothetical protein, conserved	—	OG6 LdBPK_180550.1 ↔ LdBPK_181230.1 OG6 TCSYLVIO_006181 ↔ TCSYLVIO_006246 OG7 TCSYLVIO_006181 ↔ TCSYLVIO_006246 OG7 LdBPK_180550.1 ↔ LdBPK_181230.1	Both
TcIL3000_0_50370 ⚠ tubulin folding cofactor D, putative (fragmen	—	OG6 LdBPK_181220.1 ↔ LdBPK_242100.1 OG6 LdBPK_181230.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_006246 OG7 LdBPK_181220.1 ↔ LdBPK_242100.1 +2 more	Both
TcIL3000_0_28240 cysteinyl-tRNA synthetase, putative	—	OG6 LdBPK_120255.1 ↔ LdBPK_181220.1 OG6 LdBPK_120255.1 ↔ LdBPK_181230.1 OG6 Tb927.10.12890 ↔ Tb927.6.950 OG7 Tb927.10.12890 ↔ Tb927.6.950 +2 more	Both
TcIL3000_10_710 ⚠ hook complex protein, conserved (fragment)	—	OG7 LdBPK_181230.1 ↔ LdBPK_332020.1 OG7 TCSYLVIO_005619 ↔ TCSYLVIO_006246	OG7
TcIL3000_4_2130 ⚠ asparaginyl-tRNA synthetase, putative	—	OG6 LdBPK_181220.1 ↔ LdBPK_342110.1 OG6 LdBPK_181230.1 ↔ LdBPK_342110.1 OG7 LdBPK_181220.1 ↔ LdBPK_342110.1 OG7 LdBPK_181230.1 ↔ LdBPK_342110.1 +1 more	Both
TcIL3000.11.2830 ⚠ ribosome assembly protein RRB1, putative	—	OG6 TCSYLVIO_005619 ↔ TCSYLVIO_006246 OG6 LdBPK_181230.1 ↔ LdBPK_332020.1 OG7 LdBPK_181230.1 ↔ LdBPK_332020.1 OG7 TCSYLVIO_005619 ↔ TCSYLVIO_006246	Both
TcIL3000_8_6040 ⚠ tubulin folding cofactor D, putative	—	OG6 LdBPK_181220.1 ↔ LdBPK_242100.1 OG6 LdBPK_181230.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_006246 OG7 LdBPK_181220.1 ↔ LdBPK_242100.1 +2 more	Both
TcIL3000_6_1480 ⚠ aspartyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_006246 OG7 LdBPK_181220.1 ↔ LdBPK_342110.1 OG7 LdBPK_181230.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_006246	Both
TcIL3000_10_1050 ⚠ OB-fold nucleic acid binding domain/tRNA synt	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_006246 OG7 LdBPK_181220.1 ↔ LdBPK_342110.1 OG7 LdBPK_181230.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_006246	Both
TcIL3000_0_30260 guide RNA associated protein, GAP2	—	OG6 LdBPK_181230.1 ↔ LdBPK_220520.1 OG6 TCSYLVIO_001262 ↔ TCSYLVIO_006246 OG7 LdBPK_181230.1 ↔ LdBPK_220520.1 OG7 TCSYLVIO_001262 ↔ TCSYLVIO_006246	Both
TcIL3000_6_2160 hypothetical protein, conserved	—	OG6 TCSYLVIO_003179 ↔ TCSYLVIO_006246 OG7 TCSYLVIO_003179 ↔ TCSYLVIO_006246	Both
TcIL3000_10_6860 ⚠ replication factor C subunit 3, putative	—	OG7 LdBPK_181220.1 ↔ LdBPK_241010.1 OG7 LdBPK_181230.1 ↔ LdBPK_241010.1	OG7
TcIL3000_10_8600 ⚠ ubiquitin-protein ligase, putative	—	OG7 LdBPK_181230.1 ↔ LdBPK_321150.1	OG7
TcIL3000_0_49170 ⚠ CRAL/TRIO domain containing protein, putative	—	OG7 LdBPK_181220.1 ↔ LdBPK_310320.1 OG7 LdBPK_181230.1 ↔ LdBPK_310320.1	OG7
TcIL3000_10_14060 ⚠ CRAL/TRIO domain containing protein, putative	—	OG7 LdBPK_181220.1 ↔ LdBPK_310320.1 OG7 LdBPK_181230.1 ↔ LdBPK_310320.1	OG7
TcIL3000_0_25410 ⚠ ATPase family associated with various cellula	—	OG7 LdBPK_181220.1 ↔ LdBPK_241010.1 OG7 LdBPK_181230.1 ↔ LdBPK_241010.1	OG7
TcIL3000_0_39040 ⚠ hypothetical protein (fragment)	—	OG7 LdBPK_181220.1 ↔ LdBPK_241010.1 OG7 LdBPK_181230.1 ↔ LdBPK_241010.1	OG7
TcIL3000_10_7240 ⚠ Concanavalin A-like lectin/glucanases superfa	—	OG7 LdBPK_181230.1 ↔ LdBPK_300970.1 OG7 LdBPK_161180.1 ↔ LdBPK_181220.1 OG7 LdBPK_161180.1 ↔ LdBPK_181230.1	OG7
TcIL3000_0_03820 ⚠ Eukaryotic translation initiation factor 4E-2	—	OG7 LdBPK_181220.1 ↔ LdBPK_300460.1 OG7 LdBPK_181230.1 ↔ LdBPK_300460.1	OG7
TcIL3000_9_5450 ⚠ IQ calmodulin-binding motif containing protei	—	OG7 LdBPK_181220.1 ↔ LdBPK_352820.1 OG7 LdBPK_181230.1 ↔ LdBPK_352820.1	OG7
TcIL3000_4_3500 ⚠ CRAL/TRIO domain containing protein, putative	—	OG7 LdBPK_181220.1 ↔ LdBPK_310320.1 OG7 LdBPK_181230.1 ↔ LdBPK_310320.1	OG7
TcIL3000.11.10020 ⚠ replication factor C, subunit 4, putative	—	OG7 LdBPK_181220.1 ↔ LdBPK_241010.1 OG7 LdBPK_181230.1 ↔ LdBPK_241010.1	OG7
TcIL3000.11.14340 ⚠ Outer row dynein-assembly protein 7	—	OG7 LdBPK_181220.1 ↔ LdBPK_261200.1 OG7 LdBPK_181230.1 ↔ LdBPK_261200.1	OG7
TcIL3000_10_7230 ⚠ Concanavalin A-like lectin/glucanases superfa	—	OG7 LdBPK_181230.1 ↔ LdBPK_300970.1 OG7 LdBPK_161180.1 ↔ LdBPK_181220.1 OG7 LdBPK_161180.1 ↔ LdBPK_181230.1	OG7
TcIL3000.11.11760 ⚠ Leucine Rich repeats (2 copies), putative	—	OG7 LdBPK_181220.1 ↔ LdBPK_261200.1 OG7 LdBPK_181230.1 ↔ LdBPK_261200.1	OG7
TcIL3000.11.2280 ⚠ metallo-peptidase, Clan MF, Family M17 (fragm	—	OG7 LdBPK_110640.1 ↔ LdBPK_181220.1 OG7 LdBPK_110640.1 ↔ LdBPK_181230.1	OG7
TcIL3000_0_24310 ⚠ hypothetical protein (fragment)	—	OG7 LdBPK_110640.1 ↔ LdBPK_181220.1 OG7 LdBPK_110640.1 ↔ LdBPK_181230.1	OG7
TcIL3000_7_5700 ⚠ zinc-finger of a C2HC-type, putative	—	OG7 TCSYLVIO_006138 ↔ TCSYLVIO_006246	OG7
TcIL3000.11.1290 ⚠ zinc-finger of a C2HC-type, putative	—	OG7 TCSYLVIO_006138 ↔ TCSYLVIO_006246	OG7
TcIL3000_0_11450 ⚠ hypothetical protein, conserved (fragment)	—	OG7 TCSYLVIO_006138 ↔ TCSYLVIO_006246	OG7
TcIL3000_10_4080 ⚠ zinc-finger of a C2HC-type, putative	—	OG7 TCSYLVIO_006138 ↔ TCSYLVIO_006246	OG7
TcIL3000_10_13860 ⚠ zinc-finger of a C2HC-type/Double zinc ribbon	—	OG6 TCSYLVIO_006138 ↔ TCSYLVIO_006246 OG7 TCSYLVIO_006138 ↔ TCSYLVIO_006246	Both
TcIL3000_10_8740 paraflagellar rod component, putative	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_006246 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_006246	Both
TcIL3000_0_35600 ⚠ SPRY domain containing protein, putative	—	OG6 TCSYLVIO_002919 ↔ TCSYLVIO_006246 OG7 TCSYLVIO_002919 ↔ TCSYLVIO_006246	Both
TcIL3000_0_40720 ⚠ ARM-like helical domain-containing protein	—	OG6 LdBPK_181220.1 ↔ LdBPK_312230.1 OG6 LdBPK_181230.1 ↔ LdBPK_312230.1	OG6
TcIL3000_4_1570 hypothetical protein, conserved	—	OG6 LdBPK_181230.1 ↔ LdBPK_342590.1 OG7 LdBPK_181230.1 ↔ LdBPK_342590.1	Both
TcIL3000_10_9220 ⚠ DNA mismatch repair protein MSH2, putative	—	OG6 LdBPK_181230.1 ↔ LdBPK_330420.1 OG7 LdBPK_181230.1 ↔ LdBPK_330420.1	Both
TcIL3000_0_09130 ⚠ ATP-dependent RNA helicase, putative	—	OG6 LdBPK_181230.1 ↔ LdBPK_310260.1	OG6
TcIL3000_5_1940 GMP reductase	—	OG6 LdBPK_181220.1 ↔ LdBPK_191590.1 OG6 LdBPK_181230.1 ↔ LdBPK_191590.1	OG6
TcIL3000_5_4560 ⚠ U6 snRNA-associated Sm-like protein LSm7p, pu	—	OG6 LdBPK_181230.1 ↔ LdBPK_260010.1 OG7 LdBPK_181230.1 ↔ LdBPK_260010.1	Both
TcIL3000_10_4840 hypothetical protein, conserved	—	OG6 LdBPK_181220.1 ↔ LdBPK_361430.1 OG6 LdBPK_181230.1 ↔ LdBPK_361430.1 OG7 LdBPK_181220.1 ↔ LdBPK_361430.1 OG7 LdBPK_181230.1 ↔ LdBPK_361430.1	Both
TcIL3000_8_2270 hypothetical protein, conserved	—	OG6 LdBPK_181220.1 ↔ LdBPK_230360.1 OG6 LdBPK_181230.1 ↔ LdBPK_230360.1 OG7 LdBPK_181220.1 ↔ LdBPK_230360.1 OG7 LdBPK_181230.1 ↔ LdBPK_230360.1	Both
TcIL3000_0_19760 Ankyrin repeats (3 copies)/Zinc finger, C3HC4	—	OG6 LdBPK_020120.1 ↔ LdBPK_181220.1 OG6 LdBPK_020120.1 ↔ LdBPK_181230.1	OG6
TcIL3000.11.6870 MRB1-associated protein	—	OG6 LdBPK_110930.1 ↔ LdBPK_181220.1 OG6 LdBPK_110930.1 ↔ LdBPK_181230.1 OG7 LdBPK_110930.1 ↔ LdBPK_181220.1 OG7 LdBPK_110930.1 ↔ LdBPK_181230.1	Both
TcIL3000_7_1870 Uncharacterised protein family UPF0066, putat	—	OG6 TCSYLVIO_001255 ↔ TCSYLVIO_006246 OG7 TCSYLVIO_001255 ↔ TCSYLVIO_006246	Both
TcIL3000_0_24220 ⚠ SPRY domain containing protein, putative	—	OG6 TCSYLVIO_002919 ↔ TCSYLVIO_006246 OG7 TCSYLVIO_002919 ↔ TCSYLVIO_006246	Both
TcIL3000.11.6930 leucine-rich repeat protein (LRRP), putative	—	OG6 LdBPK_110890.1 ↔ LdBPK_181220.1 OG6 LdBPK_110890.1 ↔ LdBPK_181230.1 OG7 LdBPK_110890.1 ↔ LdBPK_181220.1 OG7 LdBPK_110890.1 ↔ LdBPK_181230.1	Both
TcIL3000_0_21000 ⚠ hypothetical protein, conserved (fragment)	—	OG6 LdBPK_080420.1 ↔ LdBPK_181220.1 OG6 LdBPK_080420.1 ↔ LdBPK_181230.1 OG7 LdBPK_080420.1 ↔ LdBPK_181220.1 OG7 LdBPK_080420.1 ↔ LdBPK_181230.1	Both
TcIL3000_0_13010 ⚠ WD domain, G-beta repeat, putative	—	OG6 LdBPK_080420.1 ↔ LdBPK_181220.1 OG6 LdBPK_080420.1 ↔ LdBPK_181230.1 OG7 LdBPK_080420.1 ↔ LdBPK_181220.1 OG7 LdBPK_080420.1 ↔ LdBPK_181230.1	Both

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