TcIL3000_0_35010

metallo-peptidase, Clan MF, Family M17

Trypanosoma congolense IL3000 OG6: OG6_142599 OG7: OG7_0003405 306 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 306 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
TcIL3000_1_1430 ⚠ amidohydrolase, putative	—	OG6 LdBPK_110630.1 ↔ LdBPK_201720.1 OG6 LdBPK_110640.1 ↔ LdBPK_201720.1 OG6 LdBPK_110630.1 ↔ LdBPK_201740.1 OG6 LdBPK_110640.1 ↔ LdBPK_201740.1 +9 more	Both
TcIL3000_4_2130 ⚠ asparaginyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG6 LdBPK_110640.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG7 LdBPK_110640.1 ↔ LdBPK_342110.1 +1 more	Both
TcIL3000_5_640 ⚠ NADH-dependent fumarate reductase	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG6 LdBPK_110630.1 ↔ LdBPK_350850.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 +2 more	Both
TcIL3000_9_1440 ⚠ DNA-damage inducible protein DDI1-like protei	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_003428 OG6 LdBPK_010630.1 ↔ LdBPK_110630.1 OG6 LdBPK_010630.1 ↔ LdBPK_110640.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003428 +3 more	Both
TcIL3000_9_2560 ⚠ cysteine peptidase, Clan CA, family C2, putat	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_007342 OG6 Tb927.11.6590 ↔ Tb927.9.7540	OG6
TcIL3000_0_22360 ⚠ NADH-dependent fumarate reductase	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG6 LdBPK_110630.1 ↔ LdBPK_350850.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 +2 more	Both
TcIL3000_10_7960 ⚠ isoleucyl-tRNA synthetase, putative (fragment	—	OG6 LdBPK_110630.1 ↔ LdBPK_365870.1 OG7 LdBPK_110630.1 ↔ LdBPK_365870.1 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005560	Both
TcIL3000_6_1570 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_003118 OG6 LdBPK_110640.1 ↔ LdBPK_300580.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003118 OG7 LdBPK_110640.1 ↔ LdBPK_300580.1	Both
TcIL3000_5_620 ⚠ NADH-dependent fumarate reductase (fragment)	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG6 LdBPK_110630.1 ↔ LdBPK_350850.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 +2 more	Both
TcIL3000_10_1050 ⚠ OB-fold nucleic acid binding domain/tRNA synt	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG7 LdBPK_110640.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_005560	OG7
TcIL3000_6_1480 ⚠ aspartyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG7 LdBPK_110640.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_005560	OG7
TcIL3000_5_630 ⚠ NADH-dependent fumarate reductase	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG6 LdBPK_110630.1 ↔ LdBPK_350850.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 +2 more	Both
TcIL3000.11.8840 ⚠ DIS3-like exonuclease, putative	—	OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 LdBPK_280470.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_280470.1 OG7 LdBPK_110640.1 ↔ LdBPK_280470.1	OG7
TcIL3000_10_2980 ⚠ NADH-dependent fumarate reductase	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG6 LdBPK_110630.1 ↔ LdBPK_350850.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 +2 more	Both
TcIL3000_9_2450 ⚠ exoribonuclease DSS-1 (EMBL:AY233297), putati	—	OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 LdBPK_280470.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_280470.1 OG7 LdBPK_110640.1 ↔ LdBPK_280470.1	OG7
TcIL3000_0_13010 ⚠ WD domain, G-beta repeat, putative	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_010560 OG6 LdBPK_080420.1 ↔ LdBPK_110640.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_010560 OG7 LdBPK_080420.1 ↔ LdBPK_110640.1	Both
TcIL3000_0_54930 ⚠ cysteine peptidase, Clan CA, family C2, putat	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_007342 OG6 Tb927.11.6590 ↔ Tb927.9.7540	OG6
TcIL3000_9_2550 ⚠ hypothetical protein	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_007342 OG6 Tb927.11.6590 ↔ Tb927.9.7540	OG6
TcIL3000_6_1820 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_003145 OG6 LdBPK_110630.1 ↔ LdBPK_300810.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003145 OG7 LdBPK_110630.1 ↔ LdBPK_300810.1	Both
TcIL3000.11.8070 ⚠ exosome complex exonuclease RRP44p homologue	—	OG6 LdBPK_110630.1 ↔ LdBPK_280470.1 OG6 LdBPK_110640.1 ↔ LdBPK_280470.1 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 LdBPK_280470.1 ↔ LdBPK_332700.1 +2 more	Both
TcIL3000_0_22370 ⚠ NADH-dependent fumarate reductase	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG6 LdBPK_110630.1 ↔ LdBPK_350850.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 +2 more	Both
TcIL3000.11.10810 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_110630.1 ↔ LdBPK_364240.1 OG6 LdBPK_110640.1 ↔ LdBPK_364240.1 OG7 TCSYLVIO_005560 ↔ TCSYLVIO_008197 OG7 LdBPK_110630.1 ↔ LdBPK_364240.1 +2 more	Both
TcIL3000_0_21000 ⚠ hypothetical protein, conserved (fragment)	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_010560 OG6 LdBPK_080420.1 ↔ LdBPK_110640.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_010560 OG7 LdBPK_080420.1 ↔ LdBPK_110640.1	Both
TcIL3000_0_30110 ⚠ WD domain, G-beta repeat, putative	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_010560 OG6 LdBPK_080420.1 ↔ LdBPK_110640.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_010560 OG7 LdBPK_080420.1 ↔ LdBPK_110640.1	Both
TcIL3000_0_18970 ⚠ cysteine peptidase, Clan CA, family C2, putat	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_007342 OG6 Tb927.11.6590 ↔ Tb927.9.7540	OG6
TcIL3000_9_5450 ⚠ IQ calmodulin-binding motif containing protei	—	OG7 LdBPK_110640.1 ↔ LdBPK_352820.1	OG7
TcIL3000_3_1340 ⚠ eukaryotic translation initiation factor 3 su	—	OG7 TCSYLVIO_005560 ↔ TCSYLVIO_006404	OG7
TcIL3000_0_35820 ⚠ acyl-CoA binding protein, putative	—	OG6 LdBPK_090800.1 ↔ LdBPK_110630.1 OG6 LdBPK_090800.1 ↔ LdBPK_110640.1 OG7 LdBPK_090800.1 ↔ LdBPK_110630.1 OG7 LdBPK_090800.1 ↔ LdBPK_332700.1 +1 more	Both
TcIL3000_6_1770 ⚠ NUDC-like protein, putative, nuclear movement	—	OG7 TCSYLVIO_005560 ↔ TCSYLVIO_010327	OG7
TcIL3000_4_420 ⚠ Histidine kinase-, DNA gyrase B-, and HSP90-l	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_001670	OG7
TcIL3000_10_3720 ⚠ 6-phosphofructo-2-kinase/fructose-2,6-bisphos	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_002376	OG7
TcIL3000.11.11300 ⚠ Adaptor protein complex AP-3 subunit beta-3	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_004597	OG7
TcIL3000_10_5200 ⚠ neurobeachin/beige protein, putative	—	OG7 LdBPK_110630.1 ↔ LdBPK_332920.1	OG7
TcIL3000_7_220 ⚠ FYVE zinc finger, putative	—	OG7 LdBPK_110640.1 ↔ LdBPK_180610.1	OG7
TcIL3000.11.15970 ⚠ zinc finger protein, putative	—	OG7 LdBPK_110640.1 ↔ LdBPK_180610.1	OG7
TcIL3000_0_12430 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_110630.1 ↔ LdBPK_150690.1 OG7 LdBPK_110640.1 ↔ LdBPK_150690.1 OG7 LdBPK_150690.1 ↔ LdBPK_332700.1	OG7
TcIL3000.11.11440 ⚠ VHS domain containing protein, putative	—	OG7 TCSYLVIO_005560 ↔ TCSYLVIO_008292	OG7
TcIL3000_0_53680 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_110630.1 ↔ LdBPK_150690.1 OG7 LdBPK_110640.1 ↔ LdBPK_150690.1 OG7 LdBPK_150690.1 ↔ LdBPK_332700.1	OG7
TcIL3000_0_36000 ⚠ RNA pseudouridylate synthase, putative	—	OG7 LdBPK_110630.1 ↔ LdBPK_261140.1 OG7 LdBPK_110640.1 ↔ LdBPK_261140.1 OG7 LdBPK_261140.1 ↔ LdBPK_332700.1	OG7
TcIL3000_10_1300 ⚠ methionyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_005560 ↔ TCSYLVIO_007991	OG7
TcIL3000_7_1320 ⚠ zinc finger protein, putative	—	OG7 LdBPK_110640.1 ↔ LdBPK_180610.1	OG7
TcIL3000_0_08150 ⚠ CYC2-like cyclin, putative	—	OG7 LdBPK_110630.1 ↔ LdBPK_241960.1 OG7 LdBPK_110640.1 ↔ LdBPK_241960.1 OG7 LdBPK_241960.1 ↔ LdBPK_332700.1	OG7
TcIL3000.11.3460 ⚠ Acyl CoA binding protein, putative	—	OG7 LdBPK_090800.1 ↔ LdBPK_110630.1 OG7 LdBPK_090800.1 ↔ LdBPK_332700.1 OG7 LdBPK_090800.1 ↔ LdBPK_110640.1	OG7
TcIL3000_10_1730 ⚠ elongation factor 1-alpha, putative (fragment	—	OG7 LdBPK_111160.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_111160.1 OG7 LdBPK_110640.1 ↔ LdBPK_111160.1	OG7
TcIL3000_9_4330 ⚠ Elongation factor Tu GTP binding domain conta	—	OG7 LdBPK_111160.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_111160.1 OG7 LdBPK_110640.1 ↔ LdBPK_111160.1	OG7
TcIL3000_9_4320 ⚠ elongation factor 1-alpha, putative	—	OG7 LdBPK_111160.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_111160.1 OG7 LdBPK_110640.1 ↔ LdBPK_111160.1	OG7
TcIL3000_0_45720 ⚠ RNA pseudouridylate synthase, putative (fragm	—	OG7 LdBPK_110630.1 ↔ LdBPK_261140.1 OG7 LdBPK_110640.1 ↔ LdBPK_261140.1 OG7 LdBPK_261140.1 ↔ LdBPK_332700.1	OG7
TcIL3000_10_1960 ⚠ Lupus La protein homolog, putative	—	OG7 TCSYLVIO_005560 ↔ TCSYLVIO_006827	OG7
TcIL3000_4_3500 ⚠ CRAL/TRIO domain containing protein, putative	—	OG7 LdBPK_110640.1 ↔ LdBPK_310320.1	OG7
TcIL3000_0_04550 ⚠ N-acetyltransferase, putative	—	OG7 LdBPK_110630.1 ↔ LdBPK_130260.1 OG7 LdBPK_110640.1 ↔ LdBPK_130260.1 OG7 LdBPK_130260.1 ↔ LdBPK_332700.1	OG7

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