TcYC6_0058160

C-1-tetrahydrofolate synthase, cytoplasmic, putative
Trypanosoma cruzi Y C6 OG6: OG6_100216 OG7: OG7_0002739 237 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 237 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcYC6_0094070 ⚠
dephospho-CoA kinase, putative
— OG6
TcYC6_0105110 ⚠
calreticulin, putative
— OG6
TcYC6_0045670 ⚠
glucosamine-fructose-6-phosphate aminotransfe
— OG6
TcYC6_0054780 ⚠
transaldolase, putative
— Both
TcYC6_0043900 ⚠
hypothetical protein, conserved
— OG6
TcYC6_0056160 ⚠
putative protein kinase C substrate protein,
— OG6
TcYC6_0096150 ⚠
importin alpha, putative
— OG6
TcYC6_0092290 ⚠
hypothetical protein, conserved
— OG6
TcYC6_0103920 ⚠
hypothetical protein, conserved
— OG6
TcYC6_0054290 ⚠
hypothetical protein, conserved
— OG6
TcYC6_0066750 ⚠
hypothetical protein, conserved
— OG6
TcYC6_0064930 ⚠
hypothetical protein
— Both
TcYC6_0064940 ⚠
putative GMP synthase
— Both
TcYC6_0064790 ⚠
GMP synthase [glutamine-hydrolysing]
— Both
TcYC6_0092250 ⚠
GMP synthase [glutamine-hydrolysing]
— Both
TcYC6_0055560 ⚠
hypothetical protein, conserved
— Both
TcYC6_0102550 ⚠
leucyl-tRNA synthetase, putative
— OG6
TcYC6_0097340 ⚠
SET domain containing protein, putative
— OG6
TcYC6_0109850 ⚠
XPC-binding domain/UBA/TS-N domain containing
— OG6
TcYC6_0009260 ⚠
hypothetical protein, conserved
— Both
TcYC6_0106350 ⚠
diphthine synthase, putative
— Both
TcYC6_0074840 ⚠
protein kinase
— OG6
TcYC6_0050860 ⚠
iron superoxide dismutase, putative
— Both
TcYC6_0050990 ⚠
superoxide dismutase, putative
— Both
TcYC6_0027170 ⚠
hypothetical protein
— OG6
TcYC6_0115010 ⚠
N-myristoyl transferase, putative
— Both
TcYC6_0052500 ⚠
protein phosphatase 2C
— OG6
TcYC6_0061710 ⚠
PITH domain-containing protein
— Both
TcYC6_0080780 ⚠
stress-inducible protein STI1-like, putative
— OG6
TcYC6_0053220 ⚠
exportin 1, putative
— Both
TcYC6_0053430 ⚠
Alpha/beta hydrolase family, putative
— Both
TcYC6_0019440 ⚠
Bifunctional NAD(P)H-hydrate repair enzyme
— Both
TcYC6_0054750 ⚠
dihydroorotase, putative
— Both
TcYC6_0085920 ⚠
deoxyhypusine hydroxylase, putative
— Both
TcYC6_0084720 ⚠
rotamase, putative
— OG6
TcYC6_0005400 ⚠
tRNA (Uracil-5-)-methyltransferase, putative
— OG6
TcYC6_0115830 ⚠
CAMK/CAMKL family protein kinase, putative
— Both
TcYC6_0119740 ⚠
hypothetical protein, conserved
— Both
TcYC6_0122310 ⚠
small G-protein, putative
— OG6
TcYC6_0111760 ⚠
quinone oxidoreductase, putative
— Both
TcYC6_0111400 ⚠
inorganic pyrophosphatase, putative
— Both
TcYC6_0126540 ⚠
hypothetical protein, conserved
— OG6
TcYC6_0151050 ⚠
mucin TcMUCII, putative
— OG6
TcYC6_0075790 ⚠
TPR-repeat protein, putative
— OG6
TcYC6_0075560 ⚠
cleavage and polyadenylation specificity fact
— OG6
TcYC6_0022740 ⚠
methionyl-tRNA synthetase, putative
— OG6
TcYC6_0052370 ⚠
iron superoxide dismutase, putative
— Both
TcYC6_0062970 ⚠
hypothetical protein
— OG6
TcYC6_0047950 ⚠
hypothetical protein, conserved
— OG6
TcYC6_0074690 ⚠
hypothetical protein
— OG6
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Orthogroup expansion — connections between the query proteins
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How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.