TcYC6_0113780

glycosomal malate dehydrogenase, putative
Trypanosoma cruzi Y C6 OG6: OG6_133291 OG7: OG7_0004751 62 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 62 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcYC6_0024870 ⚠
spermidine synthase, putative
— OG7
TcYC6_0025040 ⚠
spermidine synthase, putative
— OG7
TcYC6_0005350 ⚠
aminoacylase, putative
— OG7
TcYC6_0114380 ⚠
metallo-peptidase, Clan MG, Family M24
— OG7
TcYC6_0048960 ⚠
sodium/hydrogen exchanger, putative
— OG7
TcYC6_0074850 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0175630 ⚠
trypanothione reductase, putative
— OG7
TcYC6_0037010 ⚠
oligopeptidase b
— OG7
TcYC6_0121450 ⚠
prolyl endopeptidase
— OG7
TcYC6_0101180 ⚠
Metallopeptidase family M24, putative
— OG7
TcYC6_0005340 ⚠
amidohydrolase, putative
— OG7
TcYC6_0013810 ⚠
serine peptidase, clan SC, family S9A-like pr
— OG7
TcYC6_0005360 ⚠
amidohydrolase, putative
— OG7
TcYC6_0099360 ⚠
protein phosphatase 2A, regulatory subunit B,
— OG7
TcYC6_0089760 ⚠
ruvB-like DNA helicase, putative
— OG7
TcYC6_0090640 ⚠
ruvB-like DNA helicase, putative
— OG7
TcYC6_0045560 ⚠
deoxyribose-phosphate aldolase, putative
— OG7
TcYC6_0096260 ⚠
pyridoxal kinase, putative
— OG7
TcYC6_0042220 ⚠
Present in the outer mitochondrial membrane p
— OG7
TcYC6_0095910 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0123640 ⚠
mitochondrial intermediate peptidase, putativ
— OG7
TcYC6_0059630 ⚠
thimet oligopeptidase, putative
— OG7
TcYC6_0014130 ⚠
ATP-dependent RNA helicase FAL1, putative
— OG7
TcYC6_0072740 ⚠
UDP-N-acetylglucosamine pyrophosphorylase
— OG7
TcYC6_0175560 ⚠
ATP-dependent DEAD/H RNA helicase, putative
— OG7
TcYC6_0084140 ⚠
Eukaryotic initiation factor 4A-1
— OG7
TcYC6_0021830 ⚠
ATP-dependent RNA helicase SUB2, putative
— OG7
TcYC6_0108140 ⚠
FHA domain containing protein, putative
— OG7
TcYC6_0106870 ⚠
kinetoplastid-specific phospho-protein phosph
— OG7
TcYC6_0094150 ⚠
kinetoplastid-specific phospho-protein phosph
— OG7
TcYC6_0121630 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0034510 ⚠
ecotin, putative
— OG7
TcYC6_0034970 ⚠
putative NADH-cytochrome b5 reductase
— OG7
TcYC6_0098040 ⚠
chaperonin HSP60/CNP60, putative
— OG7
TcYC6_0111240 ⚠
inosine-adenosine-guanosine-nucleosidehydrola
— OG7
TcYC6_0120660 ⚠
glutathionylspermidine synthase, putative
— OG7
TcYC6_0121550 ⚠
2,3-bisphosphoglycerate-independent phosphogl
— OG7
TcYC6_0102330 ⚠
NADH-cytochrome b5 reductase, putative
— OG7
TcYC6_0081760 ⚠
triosephosphate isomerase
— OG7
TcYC6_0127570 ⚠
succinyl-CoA ligase [GDP-forming] beta-chain,
— OG7
TcYC6_0126200 ⚠
chaperonin HSP60, mitochondrial precursor
— OG7
TcYC6_0126180 ⚠
chaperonin HSP60, mitochondrial precursor
— OG7
TcYC6_0019520 ⚠
threonine synthase, putative
— OG7
TcYC6_0051370 ⚠
cytochrome-b5 reductase, putative
— OG7
TcYC6_0058720 ⚠
Adenine phosphoribosyltransferase, putative
— OG7
TcYC6_0011340 ⚠
cytosolic malate dehydrogenase, putative
— OG7
TcYC6_0126350 ⚠
chaperonin HSP60, mitochondrial precursor
— OG7
TcYC6_0044180 ⚠
NADH-cytochrome b5 reductase, putative
— OG7
TcYC6_0077360 ⚠
cysteine peptidase, Clan CA, family C51, puta
— OG7
TcYC6_0093230 ⚠
NADH-cytochrome b5 reductase, putative
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.