C4B63_206g14

delta-1-pyrroline-5-carboxylate dehydrogenase

Trypanosoma cruzi Dm28c 2018 OG6: OG6_102275 OG7: OG7_0000710 53 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 53 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_70g123 ⚠ 3-methylcrotonoyl-CoA carboxylase beta subuni	—	OG6 Tb927.10.3210 ↔ Tb927.11.6630 OG7 Tb927.10.3210 ↔ Tb927.11.6630	Both
C4B63_43g186 ⚠ ATP synthase	—	OG6 Tb927.10.3210 ↔ Tb927.10.730 OG7 Tb927.10.3210 ↔ Tb927.10.730	Both
C4B63_59g118 ⚠ phosphoribosylpyrophosphate synthetase	—	OG6 Tb927.10.3210 ↔ Tb927.5.2960 OG7 Tb927.10.3210 ↔ Tb927.5.2960 OG7 Tb927.10.3210 ↔ Tb927.10.9430 OG7 Tb927.10.3210 ↔ Tb927.11.3030 +1 more	Both
C4B63_220g12 ⚠ peroxidoxin	—	OG6 Tb927.10.3210 ↔ Tb927.8.1990 OG7 Tb927.10.3210 ↔ Tb927.8.1990	Both
C4B63_12g220 ⚠ pyruvate phosphate dikinase	—	OG6 Tb927.10.3210 ↔ Tb927.11.6280 OG7 Tb927.10.3210 ↔ Tb927.11.6280	Both
C4B63_295g16 ⚠ tryparedoxin peroxidase	—	OG6 Tb927.10.3210 ↔ Tb927.8.1990 OG7 Tb927.10.3210 ↔ Tb927.8.1990	Both
C4B63_39g336 ⚠ S-adenosylhomocysteine hydrolase	—	OG6 Tb927.10.3210 ↔ Tb927.11.9590 OG7 Tb927.10.3210 ↔ Tb927.11.9590	Both
C4B63_69g74 ⚠ cytochrome c oxidase subunit V	—	OG6 Tb927.10.3210 ↔ Tb927.9.3170 OG7 Tb927.10.3210 ↔ Tb927.9.3170	Both
C4B63_77g29 ⚠ (H+)-ATPase G subunit	—	OG6 Tb927.10.3210 ↔ Tb927.8.2310 OG7 Tb927.10.3210 ↔ Tb927.8.2310	Both
C4B63_295g18 ⚠ tryparedoxin peroxidase	—	OG6 Tb927.10.3210 ↔ Tb927.8.1990 OG7 Tb927.10.3210 ↔ Tb927.8.1990	Both
C4B63_7g347 ⚠ V-type ATPase, A subunit	—	OG6 Tb927.10.3210 ↔ Tb927.4.1080 OG7 Tb927.10.3210 ↔ Tb927.4.1080	Both
C4B63_54g57 ⚠ vacuolar ATP synthase subunit d	—	OG6 Tb927.10.3210 ↔ Tb927.10.3760 OG7 Tb927.10.3210 ↔ Tb927.10.3760	Both
C4B63_39g357 ⚠ ATP synthase	—	OG6 Tb927.10.3210 ↔ Tb927.11.9420 OG7 Tb927.10.3210 ↔ Tb927.11.9420	Both
C4B63_2g380 ⚠ phosphoribosylpyrophosphate synthetase	—	OG6 Tb927.10.3210 ↔ Tb927.10.9430 OG6 Tb927.10.3210 ↔ Tb927.11.3030 OG7 Tb927.10.3210 ↔ Tb927.5.2960 OG7 Tb927.10.3210 ↔ Tb927.10.9430 +2 more	Both
C4B63_127g51 ⚠ acetyl-CoA carboxylase	—	OG6 Tb927.10.3210 ↔ Tb927.8.7100 OG7 Tb927.10.3210 ↔ Tb927.8.7100	Both
C4B63_123g23 ⚠ cytochrome c oxidase subunit V	—	OG6 Tb927.10.3210 ↔ Tb927.9.3170 OG7 Tb927.10.3210 ↔ Tb927.9.3170	Both
C4B63_6g258 ⚠ Vacuolar proton pump subunit B	—	OG6 Tb927.10.3210 ↔ Tb927.11.11690 OG7 Tb927.10.3210 ↔ Tb927.11.11690	Both
C4B63_6g257 ⚠ Vacuolar proton pump subunit B	—	OG6 Tb927.10.3210 ↔ Tb927.11.11690 OG7 Tb927.10.3210 ↔ Tb927.11.11690	Both
C4B63_295g20 ⚠ tryparedoxin peroxidase	—	OG6 Tb927.10.3210 ↔ Tb927.8.1990 OG7 Tb927.10.3210 ↔ Tb927.8.1990	Both
C4B63_248g13 ⚠ ATP synthase subunit	—	OG6 Tb927.1.3820 ↔ Tb927.10.3210 OG7 Tb927.1.3820 ↔ Tb927.10.3210	Both
C4B63_41g1061c ⚠ ATP synthase subunit	—	OG6 Tb927.1.3820 ↔ Tb927.10.3210 OG7 Tb927.1.3820 ↔ Tb927.10.3210	Both
C4B63_58g70 ⚠ hexokinase	—	OG6 Tb927.10.2010 ↔ Tb927.10.3210 OG6 Tb927.10.2020 ↔ Tb927.10.3210 OG7 Tb927.10.2010 ↔ Tb927.10.3210 OG7 Tb927.10.2020 ↔ Tb927.10.3210	Both
C4B63_128g65 ⚠ prolyl oligopeptidase	—	OG7 TCSYLVIO_004515 ↔ TCSYLVIO_006546	OG7
C4B63_63g37 ⚠ oligopeptidase b(fragment)	—	OG7 TCSYLVIO_004515 ↔ TCSYLVIO_006546	OG7
C4B63_128g64 ⚠ oligopeptidase b(fragment)	—	OG7 TCSYLVIO_004515 ↔ TCSYLVIO_006546	OG7
C4B63_63g36 ⚠ prolyl endopeptidase	—	OG7 TCSYLVIO_004515 ↔ TCSYLVIO_006546	OG7
C4B63_128g66 ⚠ oligopeptidase b(fragment)	—	OG7 TCSYLVIO_004515 ↔ TCSYLVIO_006546	OG7
C4B63_23g212 ⚠ serine/threonine-protein kinase	—	OG6 TCSYLVIO_004423 ↔ TCSYLVIO_004515	OG6
C4B63_2g761 ⚠ Peroxin 19	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_005818 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_005818	Both
C4B63_39g329 ⚠ glycyl-tRNA synthetase	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_009222 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_009222	Both
C4B63_47g53 ⚠ deoxyhypusine synthase	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_007258	Both
C4B63_47g52 ⚠ deoxyhypusine synthase	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_007258	Both
C4B63_22g292 ⚠ deoxyhypusine synthase	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_007258	Both
C4B63_6g564 ⚠ oligopeptidase B-like protein	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_006546 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_006546	Both
C4B63_122g16 ⚠ oligopeptidase b	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_006546 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_006546	Both
C4B63_54g22 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_005080 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_005080	Both
C4B63_127g35 ⚠ peptidase	—	OG6 TCSYLVIO_002764 ↔ TCSYLVIO_004515 OG7 TCSYLVIO_002764 ↔ TCSYLVIO_004515	Both
C4B63_18g212 ⚠ valyl-tRNA synthetase	—	OG6 TCSYLVIO_003345 ↔ TCSYLVIO_004515 OG7 TCSYLVIO_003345 ↔ TCSYLVIO_004515	Both
C4B63_46g91 ⚠ leucyl-tRNA synthetase	—	OG6 TCSYLVIO_003028 ↔ TCSYLVIO_004515 OG7 TCSYLVIO_003028 ↔ TCSYLVIO_004515	Both
C4B63_18g153 ⚠ T-complex protein 11	—	OG6 TCSYLVIO_003373 ↔ TCSYLVIO_004515 OG7 TCSYLVIO_003373 ↔ TCSYLVIO_004515	Both
C4B63_54g80 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_005125 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_005125	Both
C4B63_23g211 ⚠ protein kinase(fragment)	—	OG6 TCSYLVIO_004423 ↔ TCSYLVIO_004515	OG6
C4B63_76g41 ⚠ Probable S-adenosyl-L-methionine-binding prot	—	OG6 TCSYLVIO_001255 ↔ TCSYLVIO_004515 OG7 TCSYLVIO_001255 ↔ TCSYLVIO_004515	Both
C4B63_14g147 ⚠ phosphoribosylpyrophosphate synthetase	—	OG6 Tb927.10.3210 ↔ Tb927.10.9430 OG6 Tb927.10.3210 ↔ Tb927.11.3030 OG7 Tb927.10.3210 ↔ Tb927.5.2960 OG7 Tb927.10.3210 ↔ Tb927.10.9430 +2 more	Both
C4B63_295g22 ⚠ tryparedoxin peroxidase	—	OG6 Tb927.10.3210 ↔ Tb927.8.1990 OG7 Tb927.10.3210 ↔ Tb927.8.1990	Both
C4B63_26g257 ⚠ tryparedoxin peroxidase	—	OG6 Tb927.10.3210 ↔ Tb927.8.1990 OG7 Tb927.10.3210 ↔ Tb927.8.1990	Both
C4B63_26g255 ⚠ tryparedoxin peroxidase	—	OG6 Tb927.10.3210 ↔ Tb927.8.1990 OG7 Tb927.10.3210 ↔ Tb927.8.1990	Both
C4B63_149g19 ⚠ peroxidoxin	—	OG6 Tb927.10.3210 ↔ Tb927.8.1990 OG7 Tb927.10.3210 ↔ Tb927.8.1990	Both
C4B63_31g109 ⚠ ribose-phosphate pyrophosphokinase	—	OG6 Tb927.10.3210 ↔ Tb927.5.3170 OG7 Tb927.10.3210 ↔ Tb927.5.2960 OG7 Tb927.10.3210 ↔ Tb927.10.9430 OG7 Tb927.10.3210 ↔ Tb927.11.3030 +1 more	Both
C4B63_82g96 ⚠ (H+)-ATPase G subunit	—	OG6 Tb927.10.3210 ↔ Tb927.8.2310 OG7 Tb927.10.3210 ↔ Tb927.8.2310	Both

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