C4B63_295g14

general transcription factor IIB
Trypanosoma cruzi Dm28c 2018 OG6: OG6_145033 OG7: OG7_0043906 54 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 54 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_7g324 ⚠
Programmed cell death protein 2, C-terminal d
— OG7
C4B63_6g508 ⚠
RAD50 DNA repair protein
— Both
C4B63_28g131 ⚠
conserved hypothetical protein
— Both
C4B63_43g214 ⚠
U4/U6 small nuclear ribonuclear protein
— Both
C4B63_23g268 ⚠
Tubulin-specific chaperone E
— Both
C4B63_34g313 ⚠
casein kinase II, alpha chain
— OG6
C4B63_28g101 ⚠
signal recognition particle
— Both
C4B63_21g114 ⚠
oxidoreductase
— OG7
C4B63_199g21 ⚠
oxidoreductase
— OG7
C4B63_21g280 ⚠
ribonuclease mar1
— OG7
C4B63_7g323 ⚠
conserved hypothetical protein
— OG7
C4B63_61g23 ⚠
tRNA-dihydrouridine synthase 3
— OG7
C4B63_339g3 ⚠
tRNA-dihydrouridine synthase 3
— OG7
C4B63_19g271 ⚠
conserved hypothetical protein
— OG7
C4B63_30g290 ⚠
mercaptopyruvate sulfurtransferase
— Both
C4B63_20g51 ⚠
tRNA-dihydrouridine synthase 4
— OG7
C4B63_13g118 ⚠
tRNA-dihydrouridine synthase 2
— OG7
C4B63_24g224 ⚠
conserved hypothetical protein
— OG7
C4B63_263g16 ⚠
Programmed cell death protein 2-like
— OG7
C4B63_18g20 ⚠
Protein will die slowly
— OG7
C4B63_137g48 ⚠
receptor for activated C kinase 1
— OG7
C4B63_137g44 ⚠
receptor for activated C kinase 1
— OG7
C4B63_6g320 ⚠
receptor for activated C kinase 1
— OG7
C4B63_6g321 ⚠
receptor for activated C kinase 1
— OG7
C4B63_137g47 ⚠
receptor for activated C kinase 1
— OG7
C4B63_137g46 ⚠
receptor for activated C kinase 1
— OG7
C4B63_137g45 ⚠
receptor for activated C kinase 1
— OG7
C4B63_2g786 ⚠
ubiquitin-activating enzyme E1
— Both
C4B63_170g16 ⚠
Thiamin pyrophosphokinase 1
— Both
C4B63_46g75 ⚠
Thiamin pyrophosphokinase 1
— Both
C4B63_87g17 ⚠
pitrilysin-like metalloprotease
— Both
C4B63_87g16 ⚠
pitrilysin-like metalloprotease
— Both
C4B63_6g411 ⚠
Replication factor A 51 kDa subunit
— Both
C4B63_18g157 ⚠
DNA ligase I
— Both
C4B63_16g122 ⚠
Beta-lactamase superfamily domain containing
— Both
C4B63_13g352 ⚠
cytosolic nonspecific dipeptidase
— Both
C4B63_322g8 ⚠
dihydrouridine synthase (Dus)
— Both
C4B63_9g390 ⚠
tyrosyl-DNA Phosphodiesterase (Tdp1)
— Both
C4B63_294g17 ⚠
dihydrouridine synthase (Dus)
— Both
C4B63_6g389 ⚠
D123
— Both
C4B63_16g331 ⚠
ubiquitin-activating enzyme E1
— Both
C4B63_23g123 ⚠
conserved hypothetical protein
— Both
C4B63_350g11 ⚠
dihydrouridine synthase (Dus)
— Both
C4B63_18g68 ⚠
Zinc finger protein 277
— Both
C4B63_168g23 ⚠
Programmed cell death protein 2, C-terminal d
— Both
C4B63_313g3 ⚠
dihydrouridine synthase (Dus)(fragment)
— Both
C4B63_160g33 ⚠
ubiquitin-activating enzyme E1
— Both
C4B63_336g10 ⚠
dihydrouridine synthase (Dus)
— Both
C4B63_49g131 ⚠
conserved hypothetical protein
— Both
C4B63_42g192 ⚠
N-alpha-acetyltransferase 25, NatB auxiliary
— Both
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Orthogroup expansion — connections between the query proteins
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How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.