C4B63_6g113

ribonucleoside-diphosphate reductase large chain
Trypanosoma cruzi Dm28c 2018 OG6: OG6_100448 OG7: OG7_0004229 138 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 138 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_276g11 ⚠
DIS3-like exonuclease(fragment)
— OG7
C4B63_32g225
3-hydroxy-3-methylglutaryl-CoA synthase
— Both
C4B63_16g331 ⚠
ubiquitin-activating enzyme E1
— Both
C4B63_2g786 ⚠
ubiquitin-activating enzyme E1
— Both
C4B63_160g33 ⚠
ubiquitin-activating enzyme E1
— Both
C4B63_56g67 ⚠
Sperm-tail PG-rich repeat-containing protein
— Both
C4B63_243g7 ⚠
conserved hypothetical protein
— Both
C4B63_19g185 ⚠
isocitrate dehydrogenase
— Both
C4B63_60g116 ⚠
aspartate carbamoyltransferase
— Both
C4B63_16g302 ⚠
3-ketoacyl-CoA thiolase
— Both
C4B63_21g261 ⚠
isocitrate dehydrogenase [NADP], mitochondria
— Both
C4B63_12g410
N-acetyltransferase complex ARD1 subunit
— Both
C4B63_31g264 ⚠
aspartate carbamoyltransferase
— Both
C4B63_35g155 ⚠
aspartate carbamoyltransferase
— Both
C4B63_56g86
methylthioadenosine phosphorylase
— Both
C4B63_134g60 ⚠
aspartate carbamoyltransferase
— Both
C4B63_2g752
6-phosphogluconate dehydrogenase, decarboxyla
— Both
C4B63_42g192
N-alpha-acetyltransferase 25, NatB auxiliary
— Both
C4B63_12g179 ⚠
anion-transporting ATPase-like
— Both
C4B63_212g12 ⚠
anion-transporting ATPase-like
— Both
C4B63_17g239 ⚠
conserved hypothetical protein
— Both
C4B63_23g85 ⚠
leucine-rich repeat-containing protein
— Both
C4B63_18g142
conserved hypothetical protein
— Both
C4B63_429g2 ⚠
leucine-rich repeat-containing protein
— Both
C4B63_40g159
translation initiation factor 2 subunit
— Both
C4B63_2g388
conserved hypothetical protein
— Both
C4B63_148g30 ⚠
conserved hypothetical protein
— Both
C4B63_14g216
conserved hypothetical protein
— Both
C4B63_187g35 ⚠
protein kinase
— Both
C4B63_187g34 ⚠
protein kinase
— Both
C4B63_32g322 ⚠
protein kinase
— Both
C4B63_21g76
Adenosine deaminase-like protein
— Both
C4B63_6g521 ⚠
DIS3-like exonuclease
— Both
C4B63_22g75
conserved hypothetical protein
— Both
C4B63_30g129 ⚠
rrp44p homologue
— OG7
C4B63_6g417 ⚠
ADP-ribosylation factor GTPase activating pro
— OG7
C4B63_26g231 ⚠
ubiquitin hydrolase(fragment)
— OG7
C4B63_4g245 ⚠
Multisite-specific tRNA:(cytosine-C(5))-methy
— OG7
C4B63_25g215 ⚠
tRNA (cytosine(34)-C(5))-methyltransferase
— OG7
C4B63_75g70 ⚠
ADP-ribosylation factor GTPase activating pro
— OG7
C4B63_17g265 ⚠
Probable ADP-ribosylation factor GTPase-activ
— OG7
C4B63_193g9 ⚠
metallo-peptidase, Clan MF, Family M17
— OG7
C4B63_70g129 ⚠
metallo-peptidase, Clan MF, Family M17
— OG7
C4B63_7g79 ⚠
aspartyl-tRNA synthetase
— OG7
C4B63_233g32 ⚠
ubiquitin hydrolase
— OG7
C4B63_87g24 ⚠
nonspecific lipid-transfer protein
— OG7
C4B63_42g172 ⚠
nuclear movement protein
— OG7
C4B63_233g31 ⚠
ubiquitin hydrolase
— OG7
C4B63_12g153 ⚠
metallo-peptidase, Clan MF, Family M17
— OG7
C4B63_10g489 ⚠
ADP-ribosylation factor GTPase activating pro
— OG7
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Orthogroup expansion — connections between the query proteins
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How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.