LAMA_000046300

Methylmalonyl Co-A mutase-associated GTPase MeaB/CobW/HypB/UreG, nucleotide-binding domain containing protein, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_103973 OG7: OG7_0009141 44 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 44 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000522100 ⚠
hypothetical protein, conserved
— OG7
LAMA_000162000 ⚠
Alcohol dehydrogenase GroES-like domain/Zinc-
— Both
LAMA_000428800 ⚠
Metallo-beta-lactamase superfamily/Beta-lacta
— Both
LAMA_000012300
Protein kinase domain/Protein tyrosine kinase
— OG6
LAMA_000815700 ⚠
Tubulin-tyrosine ligase family, putative
— OG7
LAMA_000554400 ⚠
Tubulin-tyrosine ligase family, putative
— OG7
LAMA_000608200 ⚠
Tubulin-tyrosine ligase family, putative
— OG7
LAMA_000162100 ⚠
Alcohol dehydrogenase GroES-like domain/Zinc-
— OG7
LAMA_000131800 ⚠
Isochorismatase family, putative
— OG7
LAMA_000245300 ⚠
Tubulin-tyrosine ligase family, putative
— OG7
LAMA_000740500 ⚠
Dihydrouridine synthase (Dus), putative
— OG7
LAMA_000047800
TatD related DNase, putative
— Both
LAMA_000758900 ⚠
Programmed cell death protein 2, C-terminal p
— OG7
LAMA_000126100 ⚠
Tubulin-tyrosine ligase family, putative
— OG7
LAMA_000108800 ⚠
hypothetical protein
— OG7
LAMA_000684500 ⚠
Tubulin-tyrosine ligase family, putative
— OG7
LAMA_000276500 ⚠
Tubulin-tyrosine ligase family, putative
— OG7
LAMA_000261200 ⚠
Dihydrouridine synthase (Dus), putative
— OG7
LAMA_000276600 ⚠
Tubulin-tyrosine ligase family, putative
— OG7
LAMA_000174400 ⚠
Tubulin-tyrosine ligase family, putative
— OG7
LAMA_000310500 ⚠
Dihydrouridine synthase (Dus), putative
— OG7
LAMA_000184300 ⚠
Isochorismatase family, putative
— OG7
LAMA_000604900
C2H2 type zinc-finger (2 copies), putative
— Both
LAMA_000591400
N-acetyltransferase B complex (NatB) non cata
— Both
LAMA_000572900
OB-fold nucleic acid binding domain/Replicati
— Both
LAMA_000072200
Rhodanese-like domain/Domain of unknown funct
— Both
LAMA_000442500 ⚠
ThiF family/Ubiquitin-activating enzyme activ
— Both
LAMA_000575000
hypothetical protein, conserved
— Both
LAMA_000399500 ⚠
Programmed cell death protein 2, C-terminal p
— Both
LAMA_000385200 ⚠
Tubulin-tyrosine ligase family, putative
— Both
LAMA_000048000
Ubiquitin-like domain containing protein, put
— Both
LAMA_000522200 ⚠
hypothetical protein, conserved
— Both
LAMA_000797200 ⚠
ThiF family/Ubiquitin-activating enzyme E1 fo
— Both
LAMA_000727000
Tyrosyl-DNA phosphodiesterase, putative
— Both
LAMA_000641300 ⚠
Dihydrouridine synthase (Dus), putative
— Both
LAMA_000620000 ⚠
DNA ligase N terminus/ATP dependent DNA ligas
— Both
LAMA_000428900 ⚠
Beta-lactamase superfamily domain containing
— Both
LAMA_000204800
Thiamin pyrophosphokinase, vitamin B1 binding
— Both
LAMA_000711900 ⚠
Peptidase family M20/M25/M40/Peptidase dimeri
— Both
LAMA_000642000 ⚠
Peptidase family M20/M25/M40/Peptidase dimeri
— Both
LAMA_000537300
WD domain, G-beta repeat, putative
— Both
LAMA_000132000 ⚠
Isochorismatase family, putative
— Both
LAMA_000088300
Insulinase (Peptidase family M16)/Peptidase M
— Both
LAMA_000236500
Transcription factor IIB C-terminal module 1,
— Both
Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.