LAMA_000758900

Programmed cell death protein 2, C-terminal putative domain containing protein, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_136955 OG7: OG7_0004545 81 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 81 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000088300 ⚠
Insulinase (Peptidase family M16)/Peptidase M
— OG7
LAMA_000696200 ⚠
Ankyrin repeats (3 copies)/Ankyrin repeats (m
— OG7
LAMA_000572900 ⚠
OB-fold nucleic acid binding domain/Replicati
— OG7
LAMA_000591400 ⚠
N-acetyltransferase B complex (NatB) non cata
— OG7
LAMA_000727000 ⚠
Tyrosyl-DNA phosphodiesterase, putative
— OG7
LAMA_000012100 ⚠
WD domain, G-beta repeat, putative
— OG7
LAMA_000672000 ⚠
hypothetical protein, conserved
— OG7
LAMA_000507900 ⚠
ApaG domain containing protein, putative
— OG7
LAMA_000495600 ⚠
hypothetical protein, conserved
— OG7
LAMA_000116800 ⚠
Ankyrin repeats (3 copies)/Ankyrin repeats (m
— OG7
LAMA_000055200 ⚠
Ankyrin repeats (3 copies)/Ankyrin repeats (m
— OG7
LAMA_000284300 ⚠
Ankyrin repeats (many copies)/Ankyrin repeats
— OG7
LAMA_000442500 ⚠
ThiF family/Ubiquitin-activating enzyme activ
— OG7
LAMA_000793100 ⚠
Ankyrin repeats (3 copies)/Ankyrin repeats (m
— OG7
LAMA_000044900 ⚠
Ankyrin repeats (3 copies)/Ankyrin repeats (m
— OG7
LAMA_000766400 ⚠
Ankyrin repeats (many copies)/Ankyrin repeats
— OG7
LAMA_000055100 ⚠
Ankyrin repeat/DHHC palmitoyltransferase, put
— OG7
LAMA_000618200 ⚠
Ankyrin repeats (3 copies)/Ankyrin repeat/Ank
— OG7
LAMA_000046300 ⚠
Methylmalonyl Co-A mutase-associated GTPase M
— OG7
LAMA_000236500 ⚠
Transcription factor IIB C-terminal module 1,
— OG7
LAMA_000789600 ⚠
hypothetical protein, conserved
— OG7
LAMA_000108800 ⚠
hypothetical protein
— OG7
LAMA_000283700 ⚠
Hydantoinase/oxoprolinase N-terminal region/H
— OG7
LAMA_000198000 ⚠
Uncharacterized ACR, COG1678, putative
— OG7
LAMA_000061600 ⚠
Poly A polymerase head domain/Probable RNA an
— OG7
LAMA_000428800 ⚠
Metallo-beta-lactamase superfamily/Beta-lacta
— OG7
LAMA_000310500 ⚠
Dihydrouridine synthase (Dus), putative
— OG7
LAMA_000261200 ⚠
Dihydrouridine synthase (Dus), putative
— OG7
LAMA_000537300 ⚠
WD domain, G-beta repeat, putative
— OG7
LAMA_000642000 ⚠
Peptidase family M20/M25/M40/Peptidase dimeri
— OG7
LAMA_000711900 ⚠
Peptidase family M20/M25/M40/Peptidase dimeri
— OG7
LAMA_000047800 ⚠
TatD related DNase, putative
— OG7
LAMA_000428900 ⚠
Beta-lactamase superfamily domain containing
— OG7
LAMA_000620000 ⚠
DNA ligase N terminus/ATP dependent DNA ligas
— OG7
LAMA_000522100 ⚠
hypothetical protein, conserved
— OG7
LAMA_000740500 ⚠
Dihydrouridine synthase (Dus), putative
— OG7
LAMA_000604900 ⚠
C2H2 type zinc-finger (2 copies), putative
— OG7
LAMA_000641300 ⚠
Dihydrouridine synthase (Dus), putative
— OG7
LAMA_000797200 ⚠
ThiF family/Ubiquitin-activating enzyme E1 fo
— OG7
LAMA_000522200 ⚠
hypothetical protein, conserved
— OG7
LAMA_000575000 ⚠
hypothetical protein, conserved
— OG7
LAMA_000162100 ⚠
Alcohol dehydrogenase GroES-like domain/Zinc-
— OG7
LAMA_000370600 ⚠
CAF1 family ribonuclease, putative
— OG7
LAMA_000440900 ⚠
CAF1 family ribonuclease, putative
— OG7
LAMA_000014800 ⚠
RNA recognition motif. (a.k.a. RRM, RBD, or R
— OG7
LAMA_000722400 ⚠
Peptidase M16 inactive domain containing prot
— OG7
LAMA_000398600 ⚠
Insulinase (Peptidase family M16), putative
— OG7
LAMA_000201300 ⚠
hypothetical protein, conserved
— OG7
LAMA_000819600 ⚠
Ferrous iron transport protein B/50S ribosome
— OG7
LAMA_000329300 ⚠
50S ribosome-binding GTPase/Ferrous iron tran
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.