LAMA_000505600

Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain/Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain containing protein, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_100216 OG7: OG7_0002739 212 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 212 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000400500 ⚠
hypothetical protein, conserved
— Both
LAMA_000420700 ⚠
SEP domain containing protein, putative
— Both
LAMA_000453000 ⚠
Alanine racemase, N-terminal domain containin
— Both
LAMA_000566500 ⚠
Electron transfer flavoprotein domain/Electro
— Both
LAMA_000566200 ⚠
WD domain, G-beta repeat, putative
— Both
LAMA_000552500 ⚠
50S ribosome-binding GTPase/Protein of unknow
— Both
LAMA_000775400 ⚠
Aminotransferase class I and II, putative
— Both
LAMA_000457300 ⚠
Aminotransferase class I and II, putative
— Both
LAMA_000430000 ⚠
Elongation factor Tu GTP binding domain/50S r
— OG6
LAMA_000273700 ⚠
PPR repeat/Pentatricopeptide repeat domain/PP
— OG6
LAMA_000083600 ⚠
SIS domain containing protein, putative
— OG6
LAMA_000420500 ⚠
hypothetical protein, conserved
— OG6
LAMA_000647700 ⚠
Calreticulin family, putative
— OG6
LAMA_000249200 ⚠
Transaldolase/Fructose-6-phosphate aldolase,
— Both
LAMA_000175800 ⚠
hypothetical protein, conserved
— OG6
LAMA_000418500 ⚠
Glutamine amidotransferase class-I/Peptidase
— Both
LAMA_000511500 ⚠
Glucosidase II beta subunit-like protein, put
— OG6
LAMA_000203600 ⚠
tRNA synthetases class I (I, L, M and V)/tRNA
— OG6
LAMA_000254900 ⚠
hypothetical protein, conserved
— Both
LAMA_000608600 ⚠
SET domain containing protein, putative
— OG6
LAMA_000597400 ⚠
Armadillo/beta-catenin-like repeat/Atypical A
— OG6
LAMA_000065100 ⚠
Glutaredoxin, putative
— Both
LAMA_000224000 ⚠
tRNA synthetases class I (W and Y), putative
— OG6
LAMA_000214300 ⚠
N-terminal conserved domain of Nudc./CS domai
— OG6
LAMA_000342500 ⚠
Protein of unknown function (DUF2009), putati
— Both
LAMA_000223300 ⚠
Serine hydroxymethyltransferase, putative
— OG6
LAMA_000273900 ⚠
GHMP kinases N terminal domain/Mevalonate 5-d
— Both
LAMA_000274600 ⚠
Galactose mutarotase-like/Glycosyl hydrolases
— OG6
LAMA_000808200 ⚠
Protein of unknown function (DUF2009), putati
— Both
LAMA_000702600 ⚠
WD domain, G-beta repeat, putative
— Both
LAMA_000479800 ⚠
Metallo-beta-lactamase superfamily domain/Cle
— OG6
LAMA_000502500 ⚠
hypothetical protein, conserved
— OG6
LAMA_000487100 ⚠
hypothetical protein, conserved
— OG6
LAMA_000771900 ⚠
hypothetical protein, conserved
— OG6
LAMA_000760900 ⚠
hypothetical protein, conserved
— OG6
LAMA_000578700 ⚠
Serine hydroxymethyltransferase, putative
— OG6
LAMA_000681300 ⚠
Iron/manganese superoxide dismutases, alpha-h
— Both
LAMA_000624300 ⚠
Ubiquitin family/Ubiquitin carboxyl-terminal
— Both
LAMA_000541700 ⚠
WD domain, G-beta repeat, putative
— Both
LAMA_000367500 ⚠
Rab-GTPase-TBC domain containing protein, put
— OG6
LAMA_000019200 ⚠
NPL4 family, putative
— Both
LAMA_000275700 ⚠
Dephospho-CoA kinase, putative
— Both
LAMA_000261200 ⚠
Dihydrouridine synthase (Dus), putative
— OG6
LAMA_000049500 ⚠
Inorganic pyrophosphatase, putative
— Both
LAMA_000172400 ⚠
Inorganic pyrophosphatase, putative
— Both
LAMA_000222100 ⚠
YjeF-related protein N-terminus/Carbohydrate
— Both
LAMA_000047900 ⚠
hypothetical protein, conserved
— Both
LAMA_000532300 ⚠
hypothetical protein
— OG6
LAMA_000005900 ⚠
Cyclophilin type peptidyl-prolyl cis-trans is
— OG6
LAMA_000112500 ⚠
XPC-binding domain/UBA/TS-N domain containing
— OG6
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.