LINF_280030600

serine hydroxymethyltransferase (SHMT-L)
Leishmania infantum JPCM5 OG6: OG6_100262 OG7: OG7_0003031 123 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 123 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LINF_110011900 ⚠
aminopeptidase - putative
— OG7
LINF_350009100 ⚠
hypothetical protein - conserved
— Both
LINF_290028800 ⚠
UDP-glucose:Glycoprotein Glucosyltransferase
— Both
LINF_290033200 ⚠
NOL1/NOP2/sun family/FtsJ-like methyltransfer
— Both
LINF_360028800 ⚠
NOL1/NOP2/sun family - putative
— Both
LINF_270032100 ⚠
TPR-repeat protein - putative
— OG6
LINF_360005700 ⚠
stress-inducible protein STI1 homolog
— OG6
LINF_200021600 ⚠
tRNA (Uracil-5-)-methyltransferase/Protein-L-
— Both
LINF_250006800 ⚠
cleavage and polyadenylation specificity fact
— Both
LINF_220021600 ⚠
alanyl-tRNA synthetase - putative
— Both
LINF_050013400 ⚠
hypothetical protein - conserved
— Both
LINF_280007900 ⚠
DIS3-like exonuclease - putative
— Both
LINF_360066000 ⚠
isoleucyl-tRNA synthetase - putative
— Both
LINF_300038100 ⚠
glutamyl-tRNA synthetase - putative
— Both
LINF_360049500 ⚠
hypothetical protein - conserved
— Both
LINF_300009700 ⚠
aspartyl-tRNA synthetase - putative
— Both
LINF_210016300 ⚠
aspartyl-tRNA synthetase - putative
— Both
LINF_140020100 ⚠
tyrosyl-tRNA synthetase - putative
— Both
LINF_290005500 ⚠
tryptophanyl-tRNA synthetase - putative
— Both
LINF_320047000 ⚠
Gar1/Naf1 RNA binding region containing prote
— Both
LINF_270032200 ⚠
heat shock protein DNAJ - putative
— Both
LINF_210010300 ⚠
DnaJ protein - putative
— Both
LINF_030014200 ⚠
inorganic pyrophosphatase - putative
— Both
LINF_110007000 ⚠
acidocalcisomal pyrophosphatase
— Both
LINF_300012500 ⚠
co-chaperone GrpE - putative
— Both
LINF_230006100 ⚠
GDP-mannose pyrophosphorylase
— Both
LINF_170009800 ⚠
Dihydrouridine synthase (Dus) - putative
— Both
LINF_360065600 ⚠
adenylyl cyclase-associated protein - putativ
— Both
LINF_190012900 ⚠
ABC transport system ATP-binding protein - pu
— Both
LINF_330018700 ⚠
hypothetical protein - conserved
— Both
LINF_280009200 ⚠
rrp44p homologue - putative
— OG7
LINF_230008300 ⚠
tryptophanyl-tRNA synthetase - putative
— OG7
LINF_210005600 ⚠
BAR domain containing protein - putative
— OG7
LINF_210005500 ⚠
hypothetical protein - conserved
— OG7
LINF_240018700 ⚠
translation initiation factor IF-2 - putative
— OG7
LINF_300012100 ⚠
nuclear movement protein - putative
— OG7
LINF_300012600 ⚠
heat shock protein grpe
— OG7
LINF_340018100 ⚠
Dihydrouridine synthase (Dus) - putative
— OG7
LINF_360010000 ⚠
dihydrouridine synthase domain protein-like p
— OG7
LINF_310027100 ⚠
dihydrouridine synthase (Dus) - putative
— OG7
LINF_150022500 ⚠
glutaminyl-tRNA synthetase - putative
— OG7
LINF_180016500 ⚠
Multisite-specific tRNA:(cytosine-C(5))-methy
— OG7
LINF_310017600 ⚠
amidohydrolase - putative
— OG7
LINF_350034800 ⚠
PPR repeat/Pentatricopeptide repeat domain co
— OG7
LINF_290027300 ⚠
hypothetical protein - conserved
— OG7
LINF_330022300 ⚠
protein kinase - putative
— OG7
LINF_360050100 ⚠
glycosyl hydrolase-like protein
— OG7
LINF_040012900 ⚠
heat shock protein - putative
— OG7
LINF_250017100 ⚠
DNAj-like protein
— OG7
LINF_150019800 ⚠
DnaJ domain/DnaJ central domain containing pr
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.