LbrM.20.3510

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative
Leishmania braziliensis MHOM/BR/75/M2904 OG6: OG6_146732 OG7: OG7_0002830 157 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 157 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LbrM.19.1320 ⚠
phenylalanyl-tRNA synthetase, putative
— OG7
LbrM.12.0270 ⚠
cysteinyl-tRNA synthetase, putative
— OG7
LbrM.24.2100 ⚠
tubulin folding cofactor D, putative
— OG7
LbrM.29.2330 ⚠
aspartyl aminopeptidase, putative
— OG7
LbrM.20.4500 ⚠
developmentally regulated phosphoprotein-like
— OG7
LbrM.24.0010 ⚠
pyruvate dehydrogenase (lipoamide) kinase, pu
— OG7
LbrM.34.2290 ⚠
poly(A)-specific ribonuclease PARN, putative
— OG7
LbrM.23.0650 ⚠
poly(A)-specific ribonuclease PARN, putative
— OG7
LbrM.35.6680 ⚠
poly(A)-specific ribonuclease PARN, putative
— OG7
LbrM.20.1840 ⚠
asparaginyl-tRNA synthetase, putative
— OG7
LbrM.21.1130 ⚠
aspartyl-tRNA synthetase, putative
— OG7
LbrM.30.0540 ⚠
aspartyl-tRNA synthetase, putative
— OG7
LbrM.10.0990 ⚠
FKBP-type peptidyl-prolyl cis-trans isomerase
— OG7
LbrM.34.1110 ⚠
NADH-dependent fumarate reductase, putative
— OG7
LbrM.07.0990 ⚠
Domain of unknown function (DUF3437), putativ
— OG7
LbrM.35.3310 ⚠
hypothetical protein, conserved
— OG7
LbrM.35.1280 ⚠
endonuclease/exonuclease/phosphatase, putativ
— OG7
LbrM.35.0830 ⚠
Protein C21orf2 homolog, putative
— OG7
LbrM.34.3220 ⚠
Leucine Rich repeats (2 copies), putative
— OG7
LbrM.26.1260 ⚠
heat shock protein 70-related protein
— OG7
LbrM.26.0910 ⚠
chaperone protein-like protein, heat shock 70
— OG7
LbrM.19.1790 ⚠
FK506-binding protein (FKBP)-type peptidyl-pr
— OG7
LbrM.01.0790 ⚠
HSP70-like protein
— OG7
LbrM.10.0160 ⚠
hypothetical protein, conserved
— OG7
LbrM.25.2300 ⚠
Leucine-rich repeat, putative
— OG7
LbrM.15.0310 ⚠
ribonucleoprotein p18, mitochondrial precurso
— OG7
LbrM.20.1010 ⚠
uracil phosphoribosyltransferase, putative
— OG7
LbrM.33.2670 ⚠
heat shock protein, putative
— +2 more OG7
LbrM.35.0310 ⚠
peptidyl-prolyl cis-trans isomerase, putative
— OG7
LbrM.33.0350 ⚠
heat shock protein 83-1
— +2 more OG7
LbrM.29.0030 ⚠
transcription factor-like protein
— OG7
LbrM.35.5510 ⚠
Adaptor protein complex AP-3 subunit beta-3
— OG7
LbrM.20.3720 ⚠
GRIP domain containing protein, putative
— OG7
LbrM.15.0320 ⚠
ribonucleoprotein p18, mitochondrial precurso
— OG7
LbrM.33.0830 ⚠
ATP synthase F1 subunit gamma protein
— OG7
LbrM.06.0840 ⚠
protein arginine n-methyltransferase 7
— OG7
LbrM.11.0790 ⚠
adaptin-related protein-like protein
— OG7
LbrM.07.0310 ⚠
hypothetical protein, conserved
— OG7
LbrM.28.2980 ⚠
heat-shock protein hsp70, putative (fragment)
— OG7
LbrM.23.0300 ⚠
pteridine reductase 1
— OG7
LbrM.10.1320 ⚠
hypothetical protein, conserved
— OG7
LbrM.29.0780 ⚠
heat shock protein 90, putative
— +2 more OG7
LbrM.20.1490 ⚠
Zeta toxin, putative
— OG7
LbrM.11.0920 ⚠
protein transport protein SEC31, putative
— OG7
LbrM.28.1300 ⚠
luminal binding protein 1 (BiP), putative
— OG7
LbrM.22.1310 ⚠
fk506-binding protein 1-like protein
— OG7
LbrM.28.2990 ⚠
heat-shock protein hsp70, putative
— OG7
LbrM.19.1230 ⚠
peptidyl-prolyl cis-trans isomerase, macropha
— OG7
LbrM.08.0230 ⚠
ubiquitin-activating enzyme-like protein (fra
— OG7
LbrM.06.0550 ⚠
hypothetical protein, conserved
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.