LmjF.17.0725

GMP reductase
Leishmania major strain Friedlin OG6: OG6_100534 OG7: OG7_0002928 62 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 62 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LmjF.30.2980 ⚠
glyceraldehyde 3-phosphate dehydrogenase, gly
— OG6
LmjF.25.1270 ⚠
hypothetical protein, conserved
— OG6
LmjF.07.0550 ⚠
hypothetical protein, conserved
— OG6
LmjF.18.1220 ⚠
bifunctional aminoacyl-tRNA synthetase, putat
— OG6
LmjF.18.1210 ⚠
prolyl-tRNA synthetase, putative
— OG6
LmjF.32.2840 ⚠
prefoldin subunit, putative
— OG6
LmjF.27.1060 ⚠
cysteine desulfurase, putative
— Both
LmjF.11.0920 ⚠
Short C-terminal domain/PUB domain containing
— OG6
LmjF.11.0590 ⚠
3-methylcrotonoyl-CoA carboxylase beta subuni
— OG6
LmjF.29.1830 ⚠
dihydrolipoamide dehydrogenase, putative
— OG6
LmjF.25.1180 ⚠
ATP synthase subunit beta, mitochondrial, put
— OG6
LmjF.16.1390 ⚠
EMG1/NEP1 methyltransferase, putative
— Both
LmjF.35.1090 ⚠
Nucleolar protein 111, putative
— Both
LmjF.30.2970 ⚠
glyceraldehyde 3-phosphate dehydrogenase, gly
— OG6
LmjF.31.2650 ⚠
acetoin dehydrogenase e3 component-like prote
— OG6
LmjF.26.0010 ⚠
brix domain containing-like protein
— Both
LmjF.02.0140 ⚠
Ankyrin repeats (3 copies)/Zinc finger, C3HC4
— OG6
LmjF.35.0050 ⚠
2-oxoisovalerate dehydrogenase beta subunit,
— OG6
LmjF.25.1170 ⚠
ATP synthase subunit beta, mitochondrial, put
— OG6
LmjF.35.1270 ⚠
hypothetical protein, conserved
— Both
LmjF.16.0590 ⚠
carbamoyl-phosphate synthase, putative
— OG6
LmjF.35.1820 ⚠
Eukaryotic rRNA processing protein EBP2, puta
— Both
LmjF.30.0620 ⚠
ribosome biogenesis regulatory protein (RRS1)
— Both
LmjF.11.0890 ⚠
hypothetical protein, conserved
— OG6
LmjF.08.0410 ⚠
WD domain, G-beta repeat, putative
— OG6
LmjF.02.0310 ⚠
Soluble NSF attachment protein, SNAP, putativ
— OG6
LmjF.03.0900 ⚠
peter pan protein, putative
— Both
LmjF.18.1040 ⚠
5-oxoprolinase, putative
— OG6
LmjF.32.0750 ⚠
nuclear RNA binding domain
— Both
LmjF.27.0830 ⚠
hypothetical protein, conserved
— Both
LmjF.27.2250 ⚠
EMG1/NEP1 methyltransferase, putative
— OG7
LmjF.35.2770 ⚠
hypothetical protein, conserved
— OG6
LmjF.11.0630 ⚠
metallo-peptidase, Clan MF, Family M17
— OG6
LmjF.11.0620 ⚠
metallo-peptidase, Clan MF, Family M17
— OG6
LmjF.20.1670 ⚠
ribosome biogenesis protein, putative
— Both
LmjF.34.2340 ⚠
asparaginyl-tRNA synthetase, putative
— OG6
LmjF.26.1470 ⚠
farnesyltransferase beta subunit
— OG6
LmjF.35.3200 ⚠
RNA-binding protein, putative
— OG6
LmjF.35.1730 ⚠
casein kinase II, putative
— OG6
LmjF.25.1210 ⚠
hypothetical protein, conserved
— Both
LmjF.26.0840 ⚠
hypothetical protein, conserved
— OG6
LmjF.30.1760 ⚠
microtubule associated protein xmap215
— OG6
LmjF.21.0875 ⚠
hypothetical protein, conserved
— OG6
LmjF.31.0300 ⚠
CRAL/TRIO domain containing protein, putative
— OG6
LmjF.28.1910 ⚠
p21-C-terminal region-binding protein, putati
— OG6
LmjF.31.1480 ⚠
hypothetical protein, unknown function
— OG6
LmjF.31.2170 ⚠
ARM-like helical domain-containing protein
— OG6
LmjF.27.0850 ⚠
hypothetical protein, conserved
— Both
LmjF.22.0060 ⚠
transcription factor-like protein
— OG6
LmjF.33.2940 ⚠
hypothetical protein, conserved
— OG6
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.