TcCLB.506519.130

GMP reductase
Trypanosoma cruzi CL Brener Esmeraldo-like OG6: OG6_100534 OG7: OG7_0002928 61 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 61 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcCLB.506943.60 ⚠
glyceraldehyde 3-phosphate dehydrogenase, put
— OG6
TcCLB.503599.40 ⚠
Nucleolar protein 111, putative
— Both
TcCLB.508839.40 ⚠
EMG1/NEP1 methyltransferase, putative
— Both
TcCLB.461165.16 ⚠
glyceraldehyde 3-phosphate dehydrogenase, cyt
— OG6
TcCLB.506943.50 ⚠
glyceraldehyde 3-phosphate dehydrogenase, put
— OG6
TcCLB.508373.10 ⚠
glutamine dependent carbamoyl-phosphate synth
— OG6
TcCLB.509379.10 ⚠
dihydrolipoamide dehydrogenase, putative
— OG6
TcCLB.508537.10 ⚠
glyceraldehyde 3-phosphate dehydrogenase, cyt
— OG6
TcCLB.511179.114 ⚠
hypothetical protein, conserved
— Both
TcCLB.510763.109 ⚠
rRNA processing protein, putative
— Both
TcCLB.506413.70 ⚠
hypothetical protein, conserved
— Both
TcCLB.510105.230 ⚠
glyceraldehyde 3-phosphate dehydrogenase, cyt
— OG6
TcCLB.506773.40 ⚠
3-methylcrotonoyl-CoA carboxylase beta subuni
— OG6
TcCLB.508125.130 ⚠
mucin TcMUCII, putative
— OG6
TcCLB.509233.180 ⚠
ATP synthase subunit beta, mitochondrial, put
— OG6
TcCLB.447705.9 ⚠
EMG1/NEP1 methyltransferase, putative
— Both
TcCLB.507757.70 ⚠
dihydrolipoamide dehydrogenase, putative, ace
— OG6
TcCLB.511469.100 ⚠
2-oxoisovalerate dehydrogenase beta subunit,
— OG6
TcCLB.510207.10 ⚠
mucin TcMUCII, putative
— OG6
TcCLB.506409.240 ⚠
glyceraldehyde 3-phosphate dehydrogenase, C-t
— OG6
TcCLB.510101.250 ⚠
hypothetical protein, conserved
— OG6
TcCLB.503653.20 ⚠
hypothetical protein, conserved
— OG6
TcCLB.509831.10 ⚠
cysteine desulfurase, putative
— Both
TcCLB.509073.100 ⚠
prefoldin subunit, putative
— OG6
TcCLB.506755.190 ⚠
hypothetical protein, conserved
— OG6
TcCLB.507809.110 ⚠
WD domain, G-beta repeat, putative
— OG6
TcCLB.509153.40 ⚠
hypothetical protein, conserved
— OG6
TcCLB.508181.130 ⚠
peter pan protein, putative
— Both
TcCLB.509803.40 ⚠
5-oxoprolinase, putative
— OG6
TcCLB.503893.160 ⚠
hypothetical protein, conserved
— Both
TcCLB.511621.259 ⚠
EMG1/NEP1 methyltransferase, putative
— OG7
TcCLB.503899.80 ⚠
hypothetical protein, conserved
— OG6
TcCLB.506811.40 ⚠
hypothetical protein, conserved
— OG6
TcCLB.503833.69 ⚠
ribosome biogenesis protein, putative (fragme
— Both
TcCLB.509127.70 ⚠
Nop14-like family, putative
— OG6
TcCLB.510761.60 ⚠
casein kinase II, putative
— OG6
TcCLB.509233.200 ⚠
hypothetical protein, conserved
— Both
TcCLB.504427.50 ⚠
5'-AMP-activated protein kinase subunit beta,
— OG6
TcCLB.508921.40 ⚠
hypothetical protein, conserved
— OG6
TcCLB.508183.4 ⚠
aspartyl aminopeptidase, putative (fragment)
— OG6
TcCLB.506457.130 ⚠
Domain of unknown function (DUF4042), putativ
— OG6
TcCLB.507747.220 ⚠
protein farnesyltransferase, putative
— OG6
TcCLB.510741.40 ⚠
hypothetical protein, conserved
— OG6
TcCLB.510165.30 ⚠
R3H domain containing protein, putative
— OG6
TcCLB.511751.70 ⚠
microtubule associated protein xmap215
— OG6
TcCLB.507077.40 ⚠
p21-C-terminal region-binding protein, putati
— OG6
TcCLB.503893.181 ⚠
hypothetical protein, conserved (fragment)
— Both
TcCLB.511421.200 ⚠
ARM-like helical domain-containing protein
— OG6
TcCLB.506237.19 ⚠
hypothetical protein, conserved
— OG6
TcCLB.503975.50 ⚠
hypothetical protein, conserved
— OG6
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.