TcIL3000_10_2660

delta-1-pyrroline-5-carboxylate dehydrogenase, putative

Trypanosoma congolense IL3000 OG6: OG6_102275 OG7: OG7_0000710 42 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 42 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
TcIL3000_5_3590 ⚠ ribose-phosphate pyrophosphokinase, putative	—	OG6 Tb927.10.3210 ↔ Tb927.5.3170 OG7 Tb927.10.3210 ↔ Tb927.5.2960 OG7 Tb927.10.3210 ↔ Tb927.10.9430 OG7 Tb927.10.3210 ↔ Tb927.11.3030 +1 more	Both
TcIL3000_8_2020 ⚠ tryparedoxin peroxidase, putative	—	OG6 Tb927.10.3210 ↔ Tb927.8.1990 OG7 Tb927.10.3210 ↔ Tb927.8.1990	Both
TcIL3000_0_44270 3-methylcrotonoyl-CoA carboxylase beta subuni	—	OG6 Tb927.10.3210 ↔ Tb927.11.6630 OG7 Tb927.10.3210 ↔ Tb927.11.6630	Both
TcIL3000_0_20500 ⚠ S-adenosylhomocysteine hydrolase, putative	—	OG6 Tb927.10.3210 ↔ Tb927.11.9590 OG7 Tb927.10.3210 ↔ Tb927.11.9590	Both
TcIL3000_8_2290 (H+)-ATPase G subunit, putative	—	OG6 Tb927.10.3210 ↔ Tb927.8.2310 OG7 Tb927.10.3210 ↔ Tb927.8.2310	Both
TcIL3000.11.9840 ATP synthase, putative	—	OG6 Tb927.10.3210 ↔ Tb927.11.9420 OG7 Tb927.10.3210 ↔ Tb927.11.9420	Both
TcIL3000_5_3230 ⚠ phosphoribosylpyrophosphate synthetase, putat	—	OG6 Tb927.10.3210 ↔ Tb927.5.2960 OG7 Tb927.10.3210 ↔ Tb927.5.2960 OG7 Tb927.10.3210 ↔ Tb927.10.9430 OG7 Tb927.10.3210 ↔ Tb927.11.3030 +1 more	Both
TcIL3000_8_7160 ⚠ acetyl-CoA carboxylase	—	OG6 Tb927.10.3210 ↔ Tb927.8.7100 OG7 Tb927.10.3210 ↔ Tb927.8.7100	Both
TcIL3000_0_19850 ⚠ acetyl-CoA carboxylase	—	OG6 Tb927.10.3210 ↔ Tb927.8.7100 OG7 Tb927.10.3210 ↔ Tb927.8.7100	Both
TcIL3000.11.10070 ⚠ S-adenosyl-L-homocysteine hydrolase, putative	—	OG6 Tb927.10.3210 ↔ Tb927.11.9590 OG7 Tb927.10.3210 ↔ Tb927.11.9590	Both
TcIL3000.11.6820 pyruvate phosphate dikinase	—	OG6 Tb927.10.3210 ↔ Tb927.11.6280 OG7 Tb927.10.3210 ↔ Tb927.11.6280	Both
TcIL3000_10_590 ATP synthase, putative	—	OG6 Tb927.10.3210 ↔ Tb927.10.730 OG7 Tb927.10.3210 ↔ Tb927.10.730	Both
TcIL3000_10_8190 ⚠ phosphoribosylpyrophosphate synthetase, putat	—	OG6 Tb927.10.3210 ↔ Tb927.10.9430 OG6 Tb927.10.3210 ↔ Tb927.11.3030 OG7 Tb927.10.3210 ↔ Tb927.5.2960 OG7 Tb927.10.3210 ↔ Tb927.10.9430 +2 more	Both
TcIL3000_10_3620 2-oxoisovalerate dehydrogenase beta subunit,	—	OG6 Tb927.10.3210 ↔ Tb927.10.4330 OG7 Tb927.10.3210 ↔ Tb927.10.4330	Both
TcIL3000.11.12320 Vacuolar proton pump subunit B, putative	—	OG6 Tb927.10.3210 ↔ Tb927.11.11690 OG7 Tb927.10.3210 ↔ Tb927.11.11690	Both
TcIL3000_0_60440 ⚠ ribose-phosphate pyrophosphokinase, putative	—	OG6 Tb927.10.3210 ↔ Tb927.5.3170 OG7 Tb927.10.3210 ↔ Tb927.5.2960 OG7 Tb927.10.3210 ↔ Tb927.10.9430 OG7 Tb927.10.3210 ↔ Tb927.11.3030 +1 more	Both
TcIL3000_0_52640 cytochrome oxidase subunit V	—	OG6 Tb927.10.3210 ↔ Tb927.9.3170 OG7 Tb927.10.3210 ↔ Tb927.9.3170	Both
TcIL3000_0_38930 ⚠ hexokinase, putative	—	OG6 Tb927.10.2010 ↔ Tb927.10.3210 OG6 Tb927.10.2020 ↔ Tb927.10.3210 OG7 Tb927.10.2010 ↔ Tb927.10.3210 OG7 Tb927.10.2020 ↔ Tb927.10.3210	Both
TcIL3000_0_38940 ⚠ hexokinase	—	OG6 Tb927.10.2010 ↔ Tb927.10.3210 OG6 Tb927.10.2020 ↔ Tb927.10.3210 OG7 Tb927.10.2010 ↔ Tb927.10.3210 OG7 Tb927.10.2020 ↔ Tb927.10.3210	Both
TcIL3000_5_4750 ⚠ prolyl oligopeptidase, putative	—	OG7 TCSYLVIO_004515 ↔ TCSYLVIO_006546	OG7
TcIL3000_10_6890 ⚠ prolyl endopeptidase	—	OG7 TCSYLVIO_004515 ↔ TCSYLVIO_006546	OG7
TcIL3000_6_4220 T-complex protein 11, putative	—	OG6 TCSYLVIO_003373 ↔ TCSYLVIO_004515 OG7 TCSYLVIO_003373 ↔ TCSYLVIO_004515	Both
TcIL3000_9_5070 Peroxin 19	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_005818 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_005818	Both
TcIL3000_7_4140 ⚠ serine peptidase, clan SC, family S9A-like pr	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_006546 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_006546	Both
TcIL3000_0_35790 ⚠ oligopeptidase b	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_006546 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_006546	Both
TcIL3000_10_3350 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_005080 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_005080	Both
TcIL3000_10_3340 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_005080 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_005080	Both
TcIL3000.11.10140 glycyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_009222 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_009222	Both
TcIL3000_8_7090 ⚠ peptidase, putative	—	OG6 TCSYLVIO_002764 ↔ TCSYLVIO_004515 OG7 TCSYLVIO_002764 ↔ TCSYLVIO_004515	Both
TcIL3000_8_7000 ⚠ metallo-peptidase, Clan ME, Family M16, putat	—	OG6 TCSYLVIO_002764 ↔ TCSYLVIO_004515 OG7 TCSYLVIO_002764 ↔ TCSYLVIO_004515	Both
TcIL3000_6_3910 valyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003345 ↔ TCSYLVIO_004515 OG7 TCSYLVIO_003345 ↔ TCSYLVIO_004515	Both
TcIL3000.11.3680 leucyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003028 ↔ TCSYLVIO_004515 OG7 TCSYLVIO_003028 ↔ TCSYLVIO_004515	Both
TcIL3000_1_360 deoxyhypusine synthase, putative	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_007258	Both
TcIL3000_3_2100 serine/threonine-protein kinase, putative	—	OG6 TCSYLVIO_004423 ↔ TCSYLVIO_004515	OG6
TcIL3000_7_1870 Uncharacterised protein family UPF0066, putat	—	OG6 TCSYLVIO_001255 ↔ TCSYLVIO_004515 OG7 TCSYLVIO_001255 ↔ TCSYLVIO_004515	Both
TcIL3000_0_20480 ⚠ S-adenosyl-L-homocysteine hydrolase/S-adenosy	—	OG6 Tb927.10.3210 ↔ Tb927.11.9590 OG7 Tb927.10.3210 ↔ Tb927.11.9590	Both
TcIL3000.11.10090 ⚠ S-adenosylhomocysteine hydrolase, putative	—	OG6 Tb927.10.3210 ↔ Tb927.11.9590 OG7 Tb927.10.3210 ↔ Tb927.11.9590	Both
TcIL3000.11.2790 ⚠ phosphoribosylpyrophosphate synthetase, putat	—	OG6 Tb927.10.3210 ↔ Tb927.10.9430 OG6 Tb927.10.3210 ↔ Tb927.11.3030 OG7 Tb927.10.3210 ↔ Tb927.5.2960 OG7 Tb927.10.3210 ↔ Tb927.10.9430 +2 more	Both
TcIL3000_10_3090 vacuolar ATP synthase subunit d, putative	—	OG6 Tb927.10.3210 ↔ Tb927.10.3760 OG7 Tb927.10.3210 ↔ Tb927.10.3760	Both
TcIL3000_4_700 V-type ATPase, A subunit, putative	—	OG6 Tb927.10.3210 ↔ Tb927.4.1080 OG7 Tb927.10.3210 ↔ Tb927.4.1080	Both
TcIL3000_9_1970 ⚠ tryparedoxin peroxidase, putative	—	OG6 Tb927.10.3210 ↔ Tb927.8.1990 OG7 Tb927.10.3210 ↔ Tb927.8.1990	Both
TcIL3000_9_1950 ⚠ tryparedoxin peroxidase	—	OG6 Tb927.10.3210 ↔ Tb927.8.1990 OG7 Tb927.10.3210 ↔ Tb927.8.1990	Both