C4B63_17g49

Pab1p-dependent poly(A) ribonuclease subunit
Trypanosoma cruzi Dm28c 2018 OG6: OG6_103887 OG7: OG7_0007201 98 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 98 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_358g16 ⚠
RNA polymerase IIA largest subunit
— OG7
C4B63_259g8 ⚠
DNA polymerase theta (helicase domain only)
— OG7
C4B63_17g284 ⚠
ATP-dependent DNA DEAD/DEAH box helicase
— OG7
C4B63_186g23 ⚠
ATP-dependent DEAD/H RNA helicase(fragment)
— OG7
C4B63_16g132 ⚠
DNA polymerase theta (helicase domain only)
— OG7
C4B63_112g13 ⚠
neurobeachin/beige-like protein(fragment)
— OG7
C4B63_47g56 ⚠
RNA polymerase IIA largest subunit
— OG7
C4B63_48g122 ⚠
neurobeachin/beige protein
— OG7
C4B63_321g29 ⚠
RNA polymerase IIA largest subunit
— OG7
C4B63_9g327 ⚠
conserved hypothetical protein
— OG7
C4B63_255g16 ⚠
RNA polymerase IIA largest subunit
— OG7
C4B63_48g123 ⚠
neurobeachin/beige protein
— OG7
C4B63_48g124 ⚠
neurobeachin/beige protein
— OG7
C4B63_21g86
conserved hypothetical protein
— OG7
C4B63_9g329 ⚠
Beige/BEACH domain
— OG7
C4B63_112g14 ⚠
neurobeachin/beige-like protein
— OG7
C4B63_104g75 ⚠
RNA polymerase IIA largest subunit
— OG7
C4B63_104g76 ⚠
RNA polymerase IIA largest subunit
— OG7
C4B63_9g328 ⚠
conserved hypothetical protein
— OG7
C4B63_136g39 ⚠
conserved hypothetical protein
— OG7
C4B63_26g318 ⚠
conserved hypothetical protein
— OG7
C4B63_2g380 ⚠
phosphoribosylpyrophosphate synthetase
— OG7
C4B63_59g118 ⚠
phosphoribosylpyrophosphate synthetase
— OG7
C4B63_14g147 ⚠
phosphoribosylpyrophosphate synthetase
— OG7
C4B63_279g5 ⚠
DNA-directed RNA polymerase II subunit 2
— OG7
C4B63_63g32 ⚠
adaptin-related protein-like
— OG7
C4B63_2g729 ⚠
structural maintenance of chromosome (SMC) fa
— OG7
C4B63_43g187 ⚠
structural maintenance of chromosome protein
— OG7
C4B63_14g249 ⚠
structural maintenance of chromosome 3
— OG7
C4B63_8g44
conserved hypothetical protein
— OG7
C4B63_124g1 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_17g277 ⚠
phosphatidylinositol 3-related kinase
— OG7
C4B63_32g333 ⚠
conserved hypothetical protein
— OG7
C4B63_12g219 ⚠
adaptin-related protein-like
— OG7
C4B63_17g278 ⚠
phosphatidylinositol 3-related kinase
— OG7
C4B63_340g8 ⚠
conserved hypothetical protein
— OG7
C4B63_22g113 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_194g21 ⚠
DNA-directed RNA polymerase III
— OG7
C4B63_63g101 ⚠
Phosphatidylinositol 3-kinase tor1
— OG7
C4B63_30g181 ⚠
rRNA methyltransferase 1, mitochondrial
— OG7
C4B63_14g103 ⚠
beta adaptin
— OG7
C4B63_7g380 ⚠
phosphatidylinositol 3-kinase(fragment)
— OG7
C4B63_7g424 ⚠
phosphatidylinositol 3-kinase(fragment)
— OG7
C4B63_124g3 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_34g361 ⚠
phosphatidylinositol kinase related protein
— OG7
C4B63_124g2 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_38g67 ⚠
adenylate kinase
— OG7
C4B63_48g169 ⚠
adenylate kinase 1
— OG7
C4B63_192g4 ⚠
adenylate kinase 1
— OG7
C4B63_44g129
protein phosphatase
— OG6
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.