LmjF.23.0550

ubiquitin-activating enzyme E1, putative
Leishmania major strain Friedlin OG6: OG6_100444 OG7: OG7_0003530 169 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 169 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LmjF.15.1300 ⚠
ubiquitin hydrolase, putative
— OG7
LmjF.35.1740 ⚠
ubiquitin hydrolase, putative
— OG7
LmjF.34.4060 ⚠
ubiquitin hydrolase, putative
— Both
LmjF.03.0690 ⚠
DEAD/DEAH box helicase, putative
— OG7
LmjF.20.0790 ⚠
tubulin-tyrosine ligase, putative
— Both
LmjF.35.2330 ⚠
Importin 1
— Both
LmjF.03.0770 ⚠
Ubiquitin-like domain containing protein, put
— Both
LmjF.35.2300 ⚠
hypothetical protein, conserved
— Both
LmjF.26.0430 ⚠
nucleotide binding protein-like protein
— Both
LmjF.28.2470 ⚠
MRP protein-like protein
— OG6
LmjF.21.0660 ⚠
nucleotide-binding protein, putative
— Both
LmjF.34.4210 ⚠
hypothetical protein, conserved
— Both
LmjF.20.0500 ⚠
hypothetical protein, conserved
— Both
LmjF.02.0360 ⚠
casein kinase II, alpha chain, putative
— OG6
LmjF.16.0310 ⚠
Met-10+ like-protein, putative
— Both
LmjF.33.0310 ⚠
ATP-binding cassette sub-family F member 1, p
— Both
LmjF.13.0780 ⚠
CMGC/MAPK protein kinase, putative
— Both
LmjF.35.0750 ⚠
proteasome activator protein pa26, putative
— Both
LmjF.21.0950 ⚠
Programmed cell death protein 2, C-terminal p
— Both
LmjF.22.1120 ⚠
Beta-lactamase superfamily domain containing
— Both
LmjF.22.1130 ⚠
Beta-lactamase superfamily domain containing
— Both
LmjF.02.0040 ⚠
Xaa-Pro aminopeptidase, putative
— Both
LmjF.25.2430 ⚠
Xaa-Pro aminopeptidase, putative
— Both
LmjF.03.0750 ⚠
TatD related DNase, putative
— Both
LmjF.05.0230 ⚠
hydrogenase, putative
— Both
LmjF.07.0720 ⚠
hypothetical protein, conserved
— OG7
LmjF.10.0570 ⚠
zinc-binding dehydrogenase-like protein
— OG7
LmjF.16.0390 ⚠
XRN 5'-3' exonuclease N-terminus, putative
— OG7
LmjF.36.4060 ⚠
regulator of chromosome condensation 1-like p
— OG7
LmjF.23.0310 ⚠
hypothetical protein, conserved
— OG7
LmjF.36.2600 ⚠
cyclin-e binding protein 1-like protein
— OG7
LmjF.05.0790 ⚠
Mitochondrial glycoprotein, putative
— OG7
LmjF.26.0750 ⚠
Regulator of chromosome condensation (RCC1) r
— OG7
LmjF.33.0200 ⚠
metallo-peptidase, Clan MC, Family M14, putat
— OG7
LmjF.32.2200 ⚠
U5 small nuclear ribonucleoprotein component,
— OG7
LmjF.34.1140 ⚠
dihydrouridine synthase (Dus), putative
— OG7
LmjF.26.2080 ⚠
hypothetical protein, conserved
— OG7
LmjF.34.3960 ⚠
HECT-domain (ubiquitin-transferase), putative
— OG7
LmjF.26.0740 ⚠
Regulator of chromosome condensation (RCC1) r
— OG7
LmjF.17.0240 ⚠
Regulator of chromosome condensation (RCC1) r
— OG7
LmjF.36.0470 ⚠
dihydrouridine synthase domain protein-like p
— OG7
LmjF.29.1970 ⚠
hypothetical protein, unknown function
— OG7
LmjF.17.0350 ⚠
dihydrouridine synthase (Dus), putative
— OG7
LmjF.27.0720 ⚠
UBA/TS-N domain containing protein, putative
— OG7
LmjF.16.1130 ⚠
tyrosyl or methionyl-tRNA synthetase-like pro
— OG7
LmjF.22.0470 ⚠
Putative tRNA binding domain containing prote
— OG7
LmjF.29.0330 ⚠
Putative GTPase activating protein for Arf, p
— OG7
LmjF.30.0735 ⚠
heat shock protein grpe
— OG7
LmjF.13.0710 ⚠
Putative GTPase activating protein for Arf, p
— OG7
LmjF.03.0060 ⚠
Met-10+ like-protein, putative
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.