LmjF.27.1620

Eukaryotic translation initiation factor 4E-1
Leishmania major strain Friedlin OG6: OG6_100627 OG7: OG7_0002303 213 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 213 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LmjF.21.0895 ⚠
aspartyl-tRNA synthetase, putative
— OG7
LmjF.28.1340 ⚠
haloacid dehalogenase-like hydrolase, putativ
— OG7
LmjF.02.0150 ⚠
Vps51/Vps67, putative
— OG7
LmjF.22.0310 ⚠
carnitine palmitoyltransferase-like protein
— OG7
LmjF.19.1540 ⚠
choline/Carnitine o-acyltransferase-like prot
— OG7
LmjF.29.0270 ⚠
hypothetical protein, conserved
— OG7
LmjF.25.1020 ⚠
dehydrogenase-like protein
— OG7
LmjF.26.2320 ⚠
hypothetical protein, conserved
— OG7
LmjF.13.0620 ⚠
hypothetical protein, conserved
— OG7
LmjF.15.0410 ⚠
hypothetical protein, conserved
— OG7
LmjF.17.1140 ⚠
WW domain containing protein, putative
— OG7
LmjF.12.0510 ⚠
WW domain containing protein, putative
— OG7
LmjF.28.2390 ⚠
WW domain containing protein, putative
— OG7
LmjF.07.0050 ⚠
alpha-adaptin-like protein
— OG7
LmjF.34.3970 ⚠
AP-1 adapter complex gamma subunit, putative
— OG7
LmjF.34.1500 ⚠
Protein of unknown function (DUF3808), putati
— OG7
LmjF.33.2780 ⚠
Concanavalin A-like lectin/glucanases superfa
— OG7
LmjF.35.4810 ⚠
BRCA1 C Terminus (BRCT) domain containing pro
— OG7
LmjF.34.0370 ⚠
Conserved oligomeric complex COG6, putative
— OG7
LmjF.36.1720 ⚠
neurobeachin/beige protein, putative
— OG7
LmjF.36.0750 ⚠
hypothetical protein, conserved
— OG7
LmjF.36.1730 ⚠
hypothetical protein, conserved
— OG7
LmjF.23.1570 ⚠
neutral sphingomyelinase activation associate
— OG7
LmjF.34.2340 ⚠
asparaginyl-tRNA synthetase, putative
— OG7
LmjF.32.0985 ⚠
Vps23 core domain containing protein, putativ
— OG7
LmjF.30.0560 ⚠
hypothetical protein, conserved
— OG7
LmjF.33.1880 ⚠
hypothetical protein, conserved
— OG7
LmjF.35.5390 ⚠
HECT-domain (ubiquitin-transferase), putative
— OG7
LmjF.27.0550 ⚠
replication factor C, subunit 4, putative
— OG7
LmjF.35.3250 ⚠
replication factor C, subunit 3, putative
— OG7
LmjF.20.1090 ⚠
hypothetical protein, conserved
— OG7
LmjF.36.6710 ⚠
replication factor C subunit 3, putative
— OG7
LmjF.17.0540 ⚠
ATPase family associated with various cellula
— OG7
LmjF.28.2460 ⚠
ribosomal protein S29, putative
— OG7
LmjF.28.2205 ⚠
ribosomal protein S29, putative
— OG7
LmjF.27.2410 ⚠
aldo-keto reductase-like protein
— OG7
LmjF.31.2880 ⚠
aldehyde reductase, putative
— OG7
LmjF.07.0280 ⚠
ubiquitin-protein ligase-like, putative
— OG7
LmjF.30.0910 ⚠
ubiquitin-protein ligase, putative
— OG7
LmjF.16.1140 ⚠
WW domain containing protein, putative
— OG7
LmjF.30.1090 ⚠
WW domain containing protein, putative
— OG7
LmjF.07.0760 ⚠
6-phosphofructo-2-kinase/fructose-2,6-biphosp
— OG7
LmjF.23.0120 ⚠
Concanavalin A-like lectin/glucanases superfa
— OG7
LmjF.32.1770 ⚠
phosphatidylethanolamine-binding protein, put
— OG7
LmjF.33.2740 ⚠
translation initiation factor IF-2, putative
— OG7
LmjF.36.5300 ⚠
hypothetical protein, conserved
— OG7
LmjF.33.2460 ⚠
Flagellum attachment zone protein 12
— OG7
LmjF.30.0460 ⚠
aspartyl-tRNA synthetase, putative
— OG7
LmjF.03.0800 ⚠
6-phosphofructo-2-kinase 1
— OG7
LmjF.24.2020 ⚠
tubulin folding cofactor D, putative
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.