TcYC6_0025030

DENN (AEX-3) domain containing protein, putative
Trypanosoma cruzi Y C6 OG6: OG6_157986 OG7: OG7_0052278 91 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 91 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcYC6_0052680 ⚠
PSP1 C-terminal conserved region, putative
— OG7
TcYC6_0100560
Domain of unknown function (DUF3437), putativ
— OG7
TcYC6_0047780 ⚠
WD domain, G-beta repeat, putative
— OG7
TcYC6_0044340 ⚠
cell cycle sequence binding phosphoprotein (R
— OG7
TcYC6_0121080 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0068420 ⚠
poly(A)-specific ribonuclease PARN, putative
— OG7
TcYC6_0095890 ⚠
ubiquitin-protein ligase
— OG7
TcYC6_0041650
hypothetical protein, conserved
— OG7
TcYC6_0017360 ⚠
putative developmentally regulated phosphopro
— OG7
TcYC6_0052970 ⚠
PPPDE putative peptidase domain containing pr
— OG7
TcYC6_0047300 ⚠
cell cycle sequence binding phosphoprotein (R
— OG7
TcYC6_0123730 ⚠
PSP1 C-terminal conserved region, putative
— OG7
TcYC6_0116820
Protein of unknown function (DUF3648), putati
— OG7
TcYC6_0062900 ⚠
PSP1 C-terminal conserved region, putative
— OG7
TcYC6_0090430 ⚠
Zn-finger in ubiquitin-hydrolases and other p
— OG7
TcYC6_0084460 ⚠
Ring finger domain/Zn-finger in ubiquitin-hyd
— Both
TcYC6_0024550
putative cAMP-specific phosphodiesterase
— Both
TcYC6_0067770
Casein kinase II
— OG6
TcYC6_0009900
vacuolar protein sorting-associated protein 3
— Both
TcYC6_0116260
putative 5-oxoprolinase
— Both
TcYC6_0098800 ⚠
protein mkt1, putative
— Both
TcYC6_0089430 ⚠
asparaginyl-tRNA synthetase, putative
— Both
TcYC6_0121920 ⚠
poly(A)-specific ribonuclease PARN, putative
— Both
TcYC6_0096200 ⚠
ubiquitin hydrolase, putative
— OG7
TcYC6_0040190 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0040200 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0092100 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0053590 ⚠
cyclin 9, putative
— OG7
TcYC6_0091190 ⚠
Histidine kinase-, DNA gyrase B-, and HSP90-l
— OG7
TcYC6_0023910 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0122430
hypothetical protein, conserved
— OG7
TcYC6_0023300 ⚠
hypothetical protein
— OG7
TcYC6_0022580 ⚠
aspartyl-tRNA synthetase, putative
— OG7
TcYC6_0095250 ⚠
aspartyl-tRNA synthetase, putative
— OG7
TcYC6_0121960 ⚠
ubiquitin-protein ligase, putative
— OG7
TcYC6_0064120
hypothetical protein, conserved
— Both
TcYC6_0067760 ⚠
ubiquitin hydrolase
— OG7
TcYC6_0091370 ⚠
ubiquitin hydrolase, putative
— OG7
TcYC6_0009350 ⚠
Peptidase C19, ubiquitin carboxyl-terminal hy
— OG7
TcYC6_0099570 ⚠
ubiquitin-protein ligase-like, putative
— OG7
TcYC6_0086990
hypothetical protein
— OG7
TcYC6_0109450 ⚠
hypothetical protein
— OG7
TcYC6_0015370 ⚠
aspartyl-tRNA synthetase, putative
— OG7
TcYC6_0081490 ⚠
ubiquitin carboxyl-terminal hydrolase, putati
— OG7
TcYC6_0045040 ⚠
cell cycle sequence binding phosphoprotein (R
— OG7
TcYC6_0101170 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0004920 ⚠
Beta-lactamase superfamily domain containing
— Both
TcYC6_0112580 ⚠
hypothetical protein, conserved
— Both
TcYC6_0109960
hypothetical protein, conserved
— OG6
TcYC6_0122950 ⚠
hypothetical protein, conserved
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.