TcYC6_0049920

exosome-associated protein 2, putative

Trypanosoma cruzi Y C6 OG6: OG6_100420 OG7: OG7_0002825 66 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 66 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
TcYC6_0019570 ⚠ ribosomal RNA processing protein 4, putative	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_010369 OG6 Tb927.6.670 ↔ Tb927.7.4670 OG6 Tb927.11.16600 ↔ Tb927.7.4670 OG6 LdBPK_140010.1 ↔ LdBPK_221430.1 +4 more	Both
TcYC6_0090240 ⚠ putative ribosomal RNA processing protein 6	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_003804 OG6 LdBPK_044330.1 ↔ LdBPK_221430.1 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_003804 OG7 LdBPK_044330.1 ↔ LdBPK_221430.1	Both
TcYC6_0005580 ⚠ exosome-associated protein 4, putative	—	OG7 Tb927.11.16600 ↔ Tb927.2.2180 OG7 Tb927.10.7450 ↔ Tb927.6.670 OG7 Tb927.10.7450 ↔ Tb927.11.16600 OG7 LdBPK_020290.1 ↔ LdBPK_221430.1	OG7
TcYC6_0127510 ⚠ Ribosomal RNA processing protein 41A	—	OG6 Tb927.10.7450 ↔ Tb927.6.670 OG6 Tb927.10.7450 ↔ Tb927.11.16600 OG7 Tb927.11.16600 ↔ Tb927.2.2180 OG7 Tb927.10.7450 ↔ Tb927.6.670 +2 more	Both
TcYC6_0024670 ⚠ putative ribosomal RNA processing protein 40	—	OG6 LdBPK_040130.1 ↔ LdBPK_221430.1 OG6 Tb927.6.670 ↔ Tb927.9.7070 OG6 Tb927.11.16600 ↔ Tb927.9.7070 OG7 Tb927.6.670 ↔ Tb927.9.7070 +2 more	Both
TcYC6_0003610 ⚠ phosphoribosylpyrophosphate synthetase, putat	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_004731	Both
TcYC6_0084350 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_003433 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_003433	Both
TcYC6_0023210 ⚠ T-complex protein 1, delta subunit, putative	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_008271 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_008271 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_001893	Both
TcYC6_0072160 ⚠ phosphoribosylpyrophosphate synthetase, putat	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_004731 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_004731	Both
TcYC6_0035970 ⚠ flagellar pocket cytoskeletal protein bilbo1	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_006469 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_006469	Both
TcYC6_0050130 ⚠ chaperonin alpha subunit, putative	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_008271 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_001893	Both
TcYC6_0068330 ⚠ helicase, putative	—	OG6 TCSYLVIO_001373 ↔ TCSYLVIO_001893	OG6
TcYC6_0044600 ⚠ proteasome beta 3 subunit, putative	—	OG6 TCSYLVIO_001736 ↔ TCSYLVIO_001893 OG7 TCSYLVIO_001736 ↔ TCSYLVIO_001893	Both
TcYC6_0070050 ⚠ proteasome beta 2 subunit, putative	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_005774 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005774 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_004939 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_006999	Both
TcYC6_0094120 ⚠ ribosomal RNA processing protein 45, putative	—	OG6 Tb927.11.16600 ↔ Tb927.6.670 OG7 Tb927.11.16600 ↔ Tb927.6.670	Both
TcYC6_0030370 ⚠ exosome component CSL4, putative	—	OG6 Tb927.11.16600 ↔ Tb927.5.1200 OG6 Tb927.5.1200 ↔ Tb927.6.670 OG7 Tb927.11.16600 ↔ Tb927.5.1200 OG7 Tb927.5.1200 ↔ Tb927.6.670	Both
TcYC6_0125570 ⚠ translation elongation factor 1-beta, putativ	—	OG6 Tb927.10.5840 ↔ Tb927.6.670 OG6 Tb927.10.5840 ↔ Tb927.11.16600 OG7 Tb927.10.5840 ↔ Tb927.6.670 OG7 Tb927.10.5840 ↔ Tb927.11.16600	Both
TcYC6_0087400 ⚠ 25 kDa translation elongation factor 1-beta,	—	OG6 Tb927.10.5840 ↔ Tb927.6.670 OG6 Tb927.10.5840 ↔ Tb927.11.16600 OG7 Tb927.10.5840 ↔ Tb927.6.670 OG7 Tb927.10.5840 ↔ Tb927.11.16600	Both
TcYC6_0044220 ⚠ proteasome alpha 7 subunit, putative	—	OG6 TCSYLVIO_001707 ↔ TCSYLVIO_001893 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_009369 OG7 TCSYLVIO_001707 ↔ TCSYLVIO_001893	Both
TcYC6_0088200 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_003934 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_003934	Both
TcYC6_0057050 ⚠ hypothetical protein, conserved	—	OG7 Tb927.11.16600 ↔ Tb927.3.1150 OG7 Tb927.3.1150 ↔ Tb927.6.670	OG7
TcYC6_0107680 ⚠ DNA-directed RNA polymerase II subunit 2, put	—	OG7 Tb927.11.16600 ↔ Tb927.11.630 OG7 Tb927.11.630 ↔ Tb927.6.670	OG7
TcYC6_0015950 ⚠ DNA-directed RNA polymerase III, putative	—	OG7 Tb927.11.16600 ↔ Tb927.11.630 OG7 Tb927.11.630 ↔ Tb927.6.670	OG7
TcYC6_0070070 ⚠ T-complex protein 1, eta subunit, putative	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_008271 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_001893	OG7
TcYC6_0073570 ⚠ T-complex protein 1, beta subunit, putative	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_008271 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_001893	OG7
TcYC6_0054830 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_006469	OG7
TcYC6_0103040 ⚠ T-complex protein 1, zeta subunit, putative	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_008271 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_001893	OG7
TcYC6_0022090 ⚠ proteasome subunit alpha type-5, putative	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_009369 OG7 TCSYLVIO_001707 ↔ TCSYLVIO_001893	OG7
TcYC6_0125780 ⚠ proteasome subunit alpha type-1, putative	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_009369 OG7 TCSYLVIO_001707 ↔ TCSYLVIO_001893	OG7
TcYC6_0127520 ⚠ ATP-dependent RNA helicase MTR4	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_004479	OG7
TcYC6_0019050 ⚠ proteasome alpha 3 subunit, putative	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_009369 OG7 TCSYLVIO_001707 ↔ TCSYLVIO_001893	OG7
TcYC6_0117350 ⚠ proteasome alpha 7 subunit, putative	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_009369 OG7 TCSYLVIO_001707 ↔ TCSYLVIO_001893	OG7
TcYC6_0065750 ⚠ ribose-phosphate pyrophosphokinase, putative	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_004731	OG7
TcYC6_0121250 ⚠ T-complex protein 1, theta subunit, putative	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_008271 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_001893	OG7
TcYC6_0113820 ⚠ DNA-directed RNA polymerases I and III subuni	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_010718	OG7
TcYC6_0108000 ⚠ DNA-directed RNA polymerase II subunit 3, put	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_010718 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_010718	Both
TcYC6_0116740 ⚠ heat shock protein 110, putative	—	OG6 Tb927.10.12710 ↔ Tb927.6.670	OG6
TcYC6_0083590 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001310 ↔ TCSYLVIO_001893 OG7 TCSYLVIO_001310 ↔ TCSYLVIO_001893	Both
TcYC6_0017210 ⚠ exosome-associated protein 1, putative	—	OG6 Tb927.1.2580 ↔ Tb927.6.670 OG6 Tb927.1.2580 ↔ Tb927.11.16600 OG7 Tb927.1.2580 ↔ Tb927.6.670 OG7 Tb927.1.2580 ↔ Tb927.11.16600	Both
TcYC6_0044190 ⚠ Phosphoenolpyruvate carboxykinase, related	—	OG6 TCSYLVIO_001704 ↔ TCSYLVIO_001893 OG7 TCSYLVIO_001704 ↔ TCSYLVIO_001893	Both
TcYC6_0076090 ⚠ Phosducin, putative	—	OG6 TCSYLVIO_000453 ↔ TCSYLVIO_001893 OG7 TCSYLVIO_000453 ↔ TCSYLVIO_001893	Both
TcYC6_0050570 ⚠ ATP binding protein-like protein, putative	—	OG6 TCSYLVIO_000453 ↔ TCSYLVIO_001893 OG7 TCSYLVIO_000453 ↔ TCSYLVIO_001893	Both
TcYC6_0075060 ⚠ RNA polymerase I second largest subunit	—	OG6 Tb927.11.630 ↔ Tb927.6.670 OG6 Tb927.11.16600 ↔ Tb927.11.630 OG7 Tb927.11.16600 ↔ Tb927.11.630 OG7 Tb927.11.630 ↔ Tb927.6.670	Both
TcYC6_0117980 ⚠ hypothetical protein, conserved	—	OG6 Tb927.3.1300 ↔ Tb927.6.670 OG6 Tb927.11.16600 ↔ Tb927.3.1300 OG7 Tb927.11.16600 ↔ Tb927.3.1300 OG7 Tb927.3.1300 ↔ Tb927.6.670	Both
TcYC6_0118130 ⚠ hypothetical protein, conserved	—	OG6 Tb927.3.1150 ↔ Tb927.6.670 OG6 Tb927.11.16600 ↔ Tb927.3.1150 OG7 Tb927.11.16600 ↔ Tb927.3.1150 OG7 Tb927.3.1150 ↔ Tb927.6.670	Both
TcYC6_0030620 ⚠ chaperonin/T-complex protein 1 gamma subunit,	—	OG6 TCSYLVIO_000177 ↔ TCSYLVIO_001893 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_008271 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_001893	Both
TcYC6_0053320 ⚠ chaperonin containing t-complex protein, puta	—	OG6 TCSYLVIO_000177 ↔ TCSYLVIO_001893 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_008271 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_001893	Both
TcYC6_0125830 ⚠ proteasome subunit beta type-5, putative	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_004939 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005774 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_004939 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_006999	Both
TcYC6_0023180 ⚠ proteasome alpha 2 subunit, putative	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_009369 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_009369 OG7 TCSYLVIO_001707 ↔ TCSYLVIO_001893	Both
TcYC6_0109730 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_004312 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_004312	Both

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