TcYC6_0099210

pitrilysin-like metalloprotease, putative
Trypanosoma cruzi Y C6 OG6: OG6_101809 OG7: OG7_0004979 152 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 152 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcYC6_0022540 ⚠
Programmed cell death protein 2, C-terminal p
— Both
TcYC6_0090760 ⚠
Programmed cell death protein 2, C-terminal p
— OG7
TcYC6_0071260 ⚠
regulator of chromosome condensation (RCC1),
— OG7
TcYC6_0076700 ⚠
Mitochondrial-processing peptidase subunit al
— Both
TcYC6_0052550
NAD+ synthase, putative
— Both
TcYC6_0062480 ⚠
putative choline/ethanolamine kinase
— Both
TcYC6_0062450 ⚠
putative choline/ethanolamine kinase
— Both
TcYC6_0031230 ⚠
poly(A)-specific ribonuclease PARN, putative
— Both
TcYC6_0121920 ⚠
poly(A)-specific ribonuclease PARN, putative
— Both
TcYC6_0109430 ⚠
Ankyrin repeats (many copies)/Ankyrin repeats
— Both
TcYC6_0049230
otubain cysteine peptidase, Clan CA, family C
— Both
TcYC6_0124300
hydrogenase, putative
— Both
TcYC6_0069150
hypothetical protein, conserved
— Both
TcYC6_0024770 ⚠
mitochondrial exoribonuclease DSS-1, putative
— OG7
TcYC6_0116650 ⚠
cholinephosphate cytidylyltransferase A, puta
— OG7
TcYC6_0073300 ⚠
choline kinase
— OG7
TcYC6_0071890 ⚠
ribosome-interacting GTPase 2, putative
— OG7
TcYC6_0009400 ⚠
mitochondrial processing peptidase alpha subu
— OG7
TcYC6_0102100 ⚠
mitochondrial processing peptidase alpha subu
— OG7
TcYC6_0068420 ⚠
poly(A)-specific ribonuclease PARN, putative
— OG7
TcYC6_0058520 ⚠
GTP-binding protein, putative
— OG7
TcYC6_0041950 ⚠
GTP-binding protein, putative
— OG7
TcYC6_0072620 ⚠
GTPase protein
— OG7
TcYC6_0071810 ⚠
GTP-binding protein, putative
— OG7
TcYC6_0062350 ⚠
mitochondrial processing peptidase, beta subu
— OG7
TcYC6_0080650 ⚠
elongation factor 2
— OG7
TcYC6_0063740 ⚠
ribonuclease mar1, putative
— OG7
TcYC6_0097300 ⚠
tubulin-tyrosine ligase-like protein, putativ
— OG7
TcYC6_0066660 ⚠
hypothetical protein
— OG7
TcYC6_0123530 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0115520 ⚠
tubulin tyrosine ligase protein, putative
— OG7
TcYC6_0175380 ⚠
metallo-peptidase, Clan MC, Family M14, putat
— OG7
TcYC6_0127450 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0044010 ⚠
regulator of chromatin condensation, putative
— OG7
TcYC6_0066640 ⚠
XRN 5'-3' exonuclease N-terminus, putative
— OG7
TcYC6_0054440 ⚠
XRN 5'-3' exonuclease N-terminus, putative
— OG7
TcYC6_0074260
hypothetical protein, conserved
— OG7
TcYC6_0028290 ⚠
ubiquitin hydrolase
— OG7
TcYC6_0075700 ⚠
tubulin-tyrosine ligase, putative
— OG7
TcYC6_0047950 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0063850 ⚠
oxidoreductase, putative
— OG7
TcYC6_0080610 ⚠
elongation factor 2
— OG7
TcYC6_0057750 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0080270 ⚠
dihydrouridine synthase, putative
— OG7
TcYC6_0091260 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0080660 ⚠
elongation factor 2
— OG7
TcYC6_0086170
hypothetical protein, conserved
— OG7
TcYC6_0051670 ⚠
small nuclear ribonucleoprotein component
— OG7
TcYC6_0043980 ⚠
hypothetical protein
— OG7
TcYC6_0116450 ⚠
hypothetical protein, conserved
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.