LbrM.20.4450

deoxyhypusine synthase, putative

Leishmania braziliensis MHOM/BR/75/M2904 OG6: OG6_101093 OG7: OG7_0005231 132 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Interactions 132 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
LbrM.20.0300 ⚠ deoxyhypusine synthase, putative	—	OG6 TCSYLVIO_004558 ↔ TCSYLVIO_007258 OG6 Tb927.1.870 ↔ Tb927.10.2750 OG7 Tb927.1.870 ↔ Tb927.10.2750 OG7 TCSYLVIO_004558 ↔ TCSYLVIO_007258	Both
LbrM.03.0170 ⚠ ABC transporter protein, putative	—	OG7 TCSYLVIO_006012 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_004558 ↔ TCSYLVIO_006012	OG7
LbrM.11.0690 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001642 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_001642 ↔ TCSYLVIO_004558	Both
LbrM.22.0290 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001161 ↔ TCSYLVIO_004558 OG6 TCSYLVIO_001161 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_001161 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_001161 ↔ TCSYLVIO_007258	Both
LbrM.06.0930 ⚠ glucosamine-fructose-6-phosphate aminotransfe	—	OG6 TCSYLVIO_001869 ↔ TCSYLVIO_004558 OG6 TCSYLVIO_001869 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_001869 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_001869 ↔ TCSYLVIO_007258	Both
LbrM.34.3170 ⚠ Peroxin 19	—	OG6 TCSYLVIO_005818 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_005818 ↔ TCSYLVIO_007258	Both
LbrM.30.1030 ⚠ ubiquitin-protein ligase, putative	—	OG6 TCSYLVIO_003155 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_003155 ↔ TCSYLVIO_004558	Both
LbrM.30.3480 ⚠ DNA ligase I, putative	—	OG6 TCSYLVIO_003375 ↔ TCSYLVIO_004558 OG6 TCSYLVIO_003375 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_003375 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_003375 ↔ TCSYLVIO_007258	Both
LbrM.30.3340 ⚠ UV excision repair RAD23-like protein	—	OG6 TCSYLVIO_003361 ↔ TCSYLVIO_004558 OG6 TCSYLVIO_003361 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_003361 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_003361 ↔ TCSYLVIO_007258	Both
LbrM.18.0020 ⚠ kinetoplast polyadenylation/uridylation facto	—	OG6 TCSYLVIO_000834 ↔ TCSYLVIO_004558 OG6 TCSYLVIO_000834 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_000834 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_000834 ↔ TCSYLVIO_007258	Both
LbrM.06.0320 ⚠ oligopeptidase B-like protein, serine peptida	—	OG6 TCSYLVIO_006546 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_006546 ↔ TCSYLVIO_007258	Both
LbrM.09.0850 ⚠ oligopeptidase b	—	OG6 TCSYLVIO_006546 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_006546 ↔ TCSYLVIO_007258	Both
LbrM.22.0530 ⚠ Uncharacterised protein family UPF0066, putat	—	OG6 TCSYLVIO_001255 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_001255 ↔ TCSYLVIO_007258	Both
LbrM.22.1120 ⚠ translation initiation factor IF-2, putative	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_004558 OG6 TCSYLVIO_001768 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_007258	Both
LbrM.26.1310 ⚠ Cupin-like domain containing protein, putativ	—	OG6 TCSYLVIO_002279 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_002279 ↔ TCSYLVIO_004558	Both
LbrM.29.2090 ⚠ UDP-glucose:glycoprotein glucosyltransferase,	—	OG6 TCSYLVIO_004363 ↔ TCSYLVIO_004558 OG6 TCSYLVIO_004363 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_004363 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_004363 ↔ TCSYLVIO_007258	Both
LbrM.35.0120 ⚠ stress-inducible protein STI1 homolog	—	OG6 TCSYLVIO_003496 ↔ TCSYLVIO_004558 OG6 TCSYLVIO_003496 ↔ TCSYLVIO_007258	OG6
LbrM.27.2600 ⚠ TPR-repeat protein, putative	—	OG6 TCSYLVIO_003496 ↔ TCSYLVIO_004558 OG6 TCSYLVIO_003496 ↔ TCSYLVIO_007258	OG6
LbrM.22.1440 ⚠ alanyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_001889 ↔ TCSYLVIO_004558 OG6 TCSYLVIO_001889 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_001889 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_001889 ↔ TCSYLVIO_007258	Both
LbrM.28.0460 ⚠ DIS3-like exonuclease, putative	—	OG6 TCSYLVIO_002525 ↔ TCSYLVIO_004558 OG6 TCSYLVIO_002526 ↔ TCSYLVIO_004558 OG6 TCSYLVIO_002525 ↔ TCSYLVIO_007258 OG6 TCSYLVIO_002526 ↔ TCSYLVIO_007258 +4 more	Both
LbrM.05.0790 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001973 ↔ TCSYLVIO_004558 OG6 TCSYLVIO_001973 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_001973 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_001973 ↔ TCSYLVIO_007258	Both
LbrM.32.4220 ⚠ Gar1/Naf1 RNA binding region, putative	—	OG6 TCSYLVIO_000836 ↔ TCSYLVIO_004558 OG6 TCSYLVIO_000836 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_000836 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_000836 ↔ TCSYLVIO_007258	Both
LbrM.03.0820 ⚠ inorganic pyrophosphatase, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_004558 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_007258	Both
LbrM.19.0110 ⚠ acidocalcisomal pyrophosphatase	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_004558 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_007258	Both
LbrM.21.0210 ⚠ serine/threonine-protein kinase-like protein	—	OG7 TCSYLVIO_004355 ↔ TCSYLVIO_004558	OG7
LbrM.07.0960 ⚠ protein kinase, putative, serine/threonine ki	—	OG7 TCSYLVIO_004355 ↔ TCSYLVIO_004558	OG7
LbrM.28.2190 ⚠ protein lipid droplet kinase (LDK)	—	OG7 TCSYLVIO_004355 ↔ TCSYLVIO_004558	OG7
LbrM.18.0720 ⚠ serine/threonine kinase-like protein, putativ	—	OG7 TCSYLVIO_004355 ↔ TCSYLVIO_004558	OG7
LbrM.28.0340 ⚠ rrp44p homologue, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_007258	OG7
LbrM.22.0750 ⚠ protein kinase, putative, serine/threonine pr	—	OG7 TCSYLVIO_004355 ↔ TCSYLVIO_004558	OG7
LbrM.35.1020 ⚠ SNF1-related protein kinases, putative	—	OG7 TCSYLVIO_004355 ↔ TCSYLVIO_004558	OG7
LbrM.33.1980 ⚠ protein kinase, putative	—	OG7 TCSYLVIO_004355 ↔ TCSYLVIO_004558	OG7
LbrM.04.0360 ⚠ mitochondrial exoribonuclease DSS-1, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_007258	OG7
LbrM.20.3010 ⚠ cleavage and polyadenylation specificity fact	—	OG7 TCSYLVIO_005414 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_004558 ↔ TCSYLVIO_005414	OG7
LbrM.15.1020 ⚠ DNA repair protein Rad9, putative	—	OG7 TCSYLVIO_004558 ↔ TCSYLVIO_007065	OG7
LbrM.34.3430 ⚠ zinc finger protein, putative	—	OG7 TCSYLVIO_004558 ↔ TCSYLVIO_006188	OG7
LbrM.33.1670 ⚠ protein kinase	—	OG7 TCSYLVIO_007258 ↔ TCSYLVIO_007401 OG7 TCSYLVIO_004558 ↔ TCSYLVIO_007401	OG7
LbrM.20.1170 ⚠ dihydrouridine synthase (Dus), putative	—	OG7 TCSYLVIO_007258 ↔ TCSYLVIO_009102 OG7 TCSYLVIO_004558 ↔ TCSYLVIO_009102	OG7
LbrM.19.1260 ⚠ FYVE zinc finger, putative	—	OG7 TCSYLVIO_004558 ↔ TCSYLVIO_006188	OG7
LbrM.26.1440 ⚠ FYVE zinc finger, putative	—	OG7 TCSYLVIO_004558 ↔ TCSYLVIO_006188	OG7
LbrM.22.0420 ⚠ Putative tRNA binding domain containing prote	—	OG7 TCSYLVIO_007258 ↔ TCSYLVIO_010624 OG7 TCSYLVIO_004558 ↔ TCSYLVIO_010624	OG7
LbrM.16.1160 ⚠ tyrosyl or methionyl-tRNA synthetase-like pro	—	OG7 TCSYLVIO_007258 ↔ TCSYLVIO_010624 OG7 TCSYLVIO_004558 ↔ TCSYLVIO_010624	OG7
LbrM.31.2160 ⚠ dihydrouridine synthase (Dus), putative	—	OG7 TCSYLVIO_007258 ↔ TCSYLVIO_009102 OG7 TCSYLVIO_004558 ↔ TCSYLVIO_009102	OG7
LbrM.23.0330 ⚠ tryptophanyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_007258 ↔ TCSYLVIO_010724 OG7 TCSYLVIO_004558 ↔ TCSYLVIO_010724	OG7
LbrM.34.4240 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_004558 ↔ TCSYLVIO_006188	OG7
LbrM.30.0780 ⚠ nuclear movement protein, putative, NUDC-like	—	OG7 TCSYLVIO_007258 ↔ TCSYLVIO_010327 OG7 TCSYLVIO_004558 ↔ TCSYLVIO_010327	OG7
LbrM.26.1280 ⚠ hypothetical protein, unknown function	—	OG7 TCSYLVIO_004558 ↔ TCSYLVIO_006188	OG7
LbrM.14.1340 ⚠ ras-like small GTPases, putative	—	OG7 TCSYLVIO_004558 ↔ TCSYLVIO_006188	OG7
LbrM.35.0560 ⚠ dihydrouridine synthase domain protein-like p	—	OG7 TCSYLVIO_007258 ↔ TCSYLVIO_009102 OG7 TCSYLVIO_004558 ↔ TCSYLVIO_009102	OG7
LbrM.24.1540 ⚠ translation initiation factor IF-2, putative	—	OG7 TCSYLVIO_001768 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_007258	OG7

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