LbrM.30.3550

S-adenosylmethionine synthetase
Leishmania braziliensis MHOM/BR/75/M2904 OG6: OG6_100388 OG7: OG7_0003674 42 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 42 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LbrM.24.0320 ⚠
fumarate hydratase, putative
— Both
LbrM.24.2140
transketolase
— Both
LbrM.03.0240 ⚠
long chain fatty Acyl CoA synthetase, putativ
— Both
LbrM.01.0520 ⚠
fatty acyl CoA syntetase 1, putative
— Both
LbrM.18.1610 ⚠
nonspecific nucleoside hydrolase
— Both
LbrM.01.0550 ⚠
long-chain-fatty-acid-CoA ligase, putative (f
— Both
LbrM.01.0540 ⚠
long-chain-fatty-acid-CoA ligase, putative
— Both
LbrM.15.1440
proliferative cell nuclear antigen (PCNA), pu
— Both
LbrM.34.4710 ⚠
glyceraldehyde-3-phosphate dehydrogenase-like
— +1 more Both
LbrM.15.1430 ⚠
glutaminyl-tRNA synthetase, putative
— Both
LbrM.29.1930 ⚠
Fumarate hydratase class I, cytosolic
— Both
LbrM.14.0130 ⚠
inosine-guanine nucleoside hydrolase, putativ
— Both
LbrM.12.0490
glucose-6-phosphate isomerase
— Both
LbrM.20.1170 ⚠
dihydrouridine synthase (Dus), putative
— OG7
LbrM.31.2160 ⚠
dihydrouridine synthase (Dus), putative
— OG7
LbrM.30.3280 ⚠
glutamyl-tRNA synthetase, putative
— OG7
LbrM.01.0560 ⚠
long-chain-fatty-acid-CoA ligase, putative
— OG7
LbrM.01.0260 ⚠
long-chain-fatty-acid-CoA ligase, putative (f
— OG7
LbrM.35.0560 ⚠
dihydrouridine synthase domain protein-like p
— OG7
LbrM.17.0880 ⚠
queuine tRNA-ribosyltransferase
— OG7
LbrM.35.5430 ⚠
aldehyde dehydrogenase, putative
— OG7
LbrM.19.0190
NGG1 interacting factor 3-like protein
— Both
LbrM.30.2880 ⚠
aldehyde dehydrogenase, putative
— Both
LbrM.30.2950 ⚠
glyceraldehyde 3-phosphate dehydrogenase, gly
— Both
LbrM.26.1260 ⚠
heat shock protein 70-related protein
— OG6
LbrM.28.3030 ⚠
heat shock protein 70, putative
— Both
LbrM.28.2980 ⚠
heat-shock protein hsp70, putative (fragment)
— OG6
LbrM.28.2970 ⚠
heat-shock protein hsp70, putative
— OG6
LbrM.28.1300 ⚠
luminal binding protein 1 (BiP), putative
— OG6
LbrM.28.2990 ⚠
heat-shock protein hsp70, putative
— OG6
LbrM.27.0040 ⚠
queuine tRNA-ribosyltransferase, putative
— Both
LbrM.27.1010
isovaleryl-coA dehydrogenase, putative
— Both
LbrM.13.0970
adenylosuccinate synthetase, putative
— Both
LbrM.05.0350
trypanothione reductase
— Both
LbrM.30.3120
valyl-tRNA synthetase, putative
— Both
LbrM.29.0910
guanine deaminase, putative
— Both
LbrM.12.0630
alanine aminotransferase
— Both
LbrM.34.0010 ⚠
pyruvate kinase
— Both
LbrM.34.0070 ⚠
pyruvate kinase, putative (fragment)
— Both
LbrM.34.0060 ⚠
pyruvate kinase
— Both
LbrM.34.0040 ⚠
pyruvate kinase
— Both
LbrM.17.0330 ⚠
dihydrouridine synthase (Dus), putative
— Both
Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.