TcCLB.506863.50

ribosomal RNA processing protein 45, putative, exosome complex exonuclease, putative, 3' exoribonuclease, putative

Trypanosoma cruzi CL Brener Esmeraldo-like OG6: OG6_100420 OG7: OG7_0002825 73 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 73 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
TcCLB.510167.29 ⚠ ribosomal RNA processing protein 4, putative,	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_010369 OG6 LdBPK_140010.1 ↔ LdBPK_221430.1 OG6 Tb927.6.670 ↔ Tb927.7.4670 OG6 Tb927.11.16600 ↔ Tb927.7.4670 +4 more	Both
TcCLB.506625.200 ⚠ exosome complex exonuclease, putative, riboso	—	OG6 LdBPK_040130.1 ↔ LdBPK_221430.1 OG6 Tb927.6.670 ↔ Tb927.9.7070 OG6 Tb927.11.16600 ↔ Tb927.9.7070 OG7 Tb927.6.670 ↔ Tb927.9.7070 +2 more	Both
TcCLB.504057.110 ⚠ exosome complex exonuclease, putative, riboso	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_003804 OG6 LdBPK_044330.1 ↔ LdBPK_221430.1 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_003804 OG7 LdBPK_044330.1 ↔ LdBPK_221430.1	Both
TcCLB.503653.30 ⚠ ribosomal RNA processing protein 41B, putativ	—	OG6 LdBPK_020290.1 ↔ LdBPK_221430.1 OG6 Tb927.11.16600 ↔ Tb927.2.2180 OG7 Tb927.11.16600 ↔ Tb927.2.2180 OG7 Tb927.10.7450 ↔ Tb927.6.670 +2 more	Both
TcCLB.510105.20 ⚠ Ribosomal RNA processing protein 41A	—	OG6 Tb927.10.7450 ↔ Tb927.6.670 OG6 Tb927.10.7450 ↔ Tb927.11.16600 OG7 Tb927.11.16600 ↔ Tb927.2.2180 OG7 Tb927.10.7450 ↔ Tb927.6.670 +2 more	Both
TcCLB.507841.34 ⚠ exosome-associated protein 4, putative	—	OG7 Tb927.11.16600 ↔ Tb927.2.2180 OG7 Tb927.10.7450 ↔ Tb927.6.670 OG7 Tb927.10.7450 ↔ Tb927.11.16600 OG7 LdBPK_020290.1 ↔ LdBPK_221430.1	OG7
TcCLB.511211.160 ⚠ heat shock protein 70 (hsp70), putative	—	OG6 Tb927.6.670 ↔ Tb927.7.710 OG6 Tb927.11.16600 ↔ Tb927.7.710	OG6
TcCLB.511211.220 ⚠ heat shock protein 70, putative	—	OG6 Tb927.6.670 ↔ Tb927.7.710 OG6 Tb927.11.16600 ↔ Tb927.7.710	OG6
TcCLB.506135.9 ⚠ heat shock 70 kDa protein, putative (fragment	—	OG6 Tb927.6.670 ↔ Tb927.7.710 OG6 Tb927.11.16600 ↔ Tb927.7.710	OG6
TcCLB.418069.10 ⚠ heat shock protein 70 (hsp70), putative (frag	—	OG6 Tb927.6.670 ↔ Tb927.7.710 OG6 Tb927.11.16600 ↔ Tb927.7.710	OG6
TcCLB.507089.80 ⚠ exosome-associated protein 2, putative	—	OG6 Tb927.11.16600 ↔ Tb927.6.670 OG7 Tb927.11.16600 ↔ Tb927.6.670	Both
TcCLB.506779.50 ⚠ proteasome beta 3 subunit, putative	—	OG6 TCSYLVIO_001736 ↔ TCSYLVIO_001893 OG7 TCSYLVIO_001736 ↔ TCSYLVIO_001893	Both
TcCLB.503613.20 ⚠ proteasome alpha 7 subunit, putative	—	OG6 TCSYLVIO_001707 ↔ TCSYLVIO_001893 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_009369 OG7 TCSYLVIO_001707 ↔ TCSYLVIO_001893	Both
TcCLB.507671.30 ⚠ 25 kDa translation elongation factor 1-beta	—	OG6 Tb927.10.5840 ↔ Tb927.6.670 OG6 Tb927.10.5840 ↔ Tb927.11.16600 OG7 Tb927.10.5840 ↔ Tb927.6.670 OG7 Tb927.10.5840 ↔ Tb927.11.16600	Both
TcCLB.508469.59 ⚠ helicase, putative	—	OG6 TCSYLVIO_001373 ↔ TCSYLVIO_001893	OG6
TcCLB.510515.139 ⚠ T-complex protein 1, gamma subunit, putative	—	OG6 TCSYLVIO_000177 ↔ TCSYLVIO_001893 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_008271 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_001893	Both
TcCLB.510517.10 ⚠ chaperonin/T-complex protein 1 gamma subunit,	—	OG6 TCSYLVIO_000177 ↔ TCSYLVIO_001893 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_008271 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_001893	Both
TcCLB.506775.180 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001704 ↔ TCSYLVIO_001893 OG7 TCSYLVIO_001704 ↔ TCSYLVIO_001893	Both
TcCLB.509455.50 ⚠ hypothetical protein, conserved	—	OG6 Tb927.3.1150 ↔ Tb927.6.670 OG6 Tb927.11.16600 ↔ Tb927.3.1150 OG7 Tb927.11.16600 ↔ Tb927.3.1150 OG7 Tb927.3.1150 ↔ Tb927.6.670	Both
TcCLB.506691.14 ⚠ ATP-dependent DEAD/H RNA helicase, putative (	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_004479 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_004479	Both
TcCLB.507083.80 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_006469	OG7
TcCLB.511145.43 ⚠ proteasome subunit alpha type-5, putative	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_009369 OG7 TCSYLVIO_001707 ↔ TCSYLVIO_001893	OG7
TcCLB.508357.90 ⚠ T-complex protein 1, beta subunit, putative	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_008271 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_001893	OG7
TcCLB.506167.40 ⚠ proteasome subunit alpha type-1, putative	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_009369 OG7 TCSYLVIO_001707 ↔ TCSYLVIO_001893	OG7
TcCLB.510105.9 ⚠ ATP-dependent DEAD/H RNA helicase, putative	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_004479	OG7
TcCLB.509583.10 ⚠ chaperonin TCP20, putative	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_008271 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_001893	OG7
TcCLB.506503.110 ⚠ DNA-directed RNA polymerases I and III subuni	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_010718	OG7
TcCLB.504213.120 ⚠ proteasome alpha 3 subunit, putative	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_009369 OG7 TCSYLVIO_001707 ↔ TCSYLVIO_001893	OG7
TcCLB.511867.50 ⚠ proteasome alpha 7 subunit, putative	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_009369 OG7 TCSYLVIO_001707 ↔ TCSYLVIO_001893	OG7
TcCLB.509767.180 ⚠ exosome component CSL4, putative	—	OG6 Tb927.11.16600 ↔ Tb927.5.1200 OG6 Tb927.5.1200 ↔ Tb927.6.670 OG7 Tb927.11.16600 ↔ Tb927.5.1200 OG7 Tb927.5.1200 ↔ Tb927.6.670	Both
TcCLB.507809.30 ⚠ ribose-phosphate pyrophosphokinase, putative	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_004731	OG7
TcCLB.511417.40 ⚠ DNA-directed RNA polymerase III, putative	—	OG7 Tb927.11.16600 ↔ Tb927.11.630 OG7 Tb927.11.630 ↔ Tb927.6.670	OG7
TcCLB.503579.40 ⚠ hypothetical protein, conserved	—	OG7 Tb927.11.16600 ↔ Tb927.3.1150 OG7 Tb927.3.1150 ↔ Tb927.6.670	OG7
TcCLB.509951.49 ⚠ DNA-directed RNA polymerase II subunit 2, put	—	OG7 Tb927.11.16600 ↔ Tb927.11.630 OG7 Tb927.11.630 ↔ Tb927.6.670	OG7
TcCLB.508813.15 ⚠ heat shock protein 70, putative (fragment)	—	OG6 Tb927.6.670 ↔ Tb927.7.710 OG6 Tb927.11.16600 ↔ Tb927.7.710	OG6
TcCLB.509543.50 ⚠ DNAK protein, putative	—	OG6 Tb927.6.670 ↔ Tb927.7.710 OG6 Tb927.11.16600 ↔ Tb927.7.710	OG6
TcCLB.511211.170 ⚠ heat shock protein 70 (hsp70), putative	—	OG6 Tb927.6.670 ↔ Tb927.7.710 OG6 Tb927.11.16600 ↔ Tb927.7.710	OG6
TcCLB.511531.40 ⚠ chaperonin alpha subunit, putative	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_008271 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_001893	Both
TcCLB.510879.30 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_003828 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_003828	Both
TcCLB.506607.19 ⚠ phosphoribosylpyrophosphate synthetase, putat	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_004731	Both
TcCLB.506795.90 ⚠ 'Cold-shock' DNA-binding domain containing pr	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_010606 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_010606	Both
TcCLB.507923.40 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_003184 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_003184	Both
TcCLB.506755.20 ⚠ paraflagellar rod component, putative	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_006797 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_006797	Both
TcCLB.468941.9 ⚠ ATP-dependent DEAD/H RNA helicase, putative (	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_004479 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_004479	Both
TcCLB.508369.50 ⚠ acetyl-CoA carboxylase (fragment)	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_002772 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_002772	Both
TcCLB.506135.110 ⚠ mitochondrial RNA binding complex 1 subunit,	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_002300 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_002300	Both
TcCLB.504867.40 ⚠ acetyltransferase, putative	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_004519 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_004519	Both
TcCLB.507811.20 ⚠ delta-adaptin, putative, adaptor complex prot	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_010530 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_010530	Both
TcCLB.510557.50 ⚠ mucin TcMUCII, putative	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_002772	OG6
TcCLB.506563.20 ⚠ exosome-associated protein 1, putative	—	OG6 Tb927.1.2580 ↔ Tb927.6.670 OG6 Tb927.1.2580 ↔ Tb927.11.16600 OG7 Tb927.1.2580 ↔ Tb927.6.670 OG7 Tb927.1.2580 ↔ Tb927.11.16600	Both

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