TcYC6_0092480

methylenetetrahydrofolate dehydrogenase-like protein, putative
Trypanosoma cruzi Y C6 OG6: OG6_200158 OG7: OG7_0002739 152 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 152 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcYC6_0008340 ⚠
phosphoenolpyruvate mutase, putative
— OG7
TcYC6_0012960 ⚠
haloacid dehalogenase-like hydrolase, putativ
— OG7
TcYC6_0095910 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0085450 ⚠
monothiol glutaredoxin, putative
— OG7
TcYC6_0070700 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0012390 ⚠
tRNA threonylcarbamoyl adenosine modification
— OG7
TcYC6_0115110 ⚠
pyruvate kinase 2, putative
— OG7
TcYC6_0049770 ⚠
enoyl-CoA hydratase/isomerase family protein,
— OG7
TcYC6_0095240 ⚠
Eukaryotic translation initiation factor 4E-4
— OG7
TcYC6_0011810 ⚠
Eukaryotic translation initiation factor 4E-3
— OG7
TcYC6_0112990 ⚠
choline/carnitine O-acyltransferase , putativ
— OG7
TcYC6_0112520 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0073580 ⚠
Serine-threonine kinase receptor-associated p
— OG7
TcYC6_0175660 ⚠
monothiol glutaredoxin, putative
— OG7
TcYC6_0125960 ⚠
putative 5'-3' exoribonuclease D
— OG7
TcYC6_0009250 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0100460 ⚠
CAMK/CAMKL family protein kinase, putative
— OG7
TcYC6_0051940 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0112320 ⚠
Soluble NSF attachment protein, SNAP, putativ
— OG7
TcYC6_0009920 ⚠
CAMK/CAMKL pseudokinase, putative
— OG7
TcYC6_0022140 ⚠
RNA polymerase II, putative
— OG7
TcYC6_0025610 ⚠
choline/carnitine O-acyltransferase , putativ
— OG7
TcYC6_0007260 ⚠
eukaryotic translation initiation factor 3 su
— OG7
TcYC6_0013770 ⚠
putative 5'-3' exoribonuclease A
— OG7
TcYC6_0079840 ⚠
eukaryotic translation initiation factor 6 (e
— OG7
TcYC6_0016600 ⚠
Mitochondrial Editosome-like Complex TUTase
— OG7
TcYC6_0115350 ⚠
Activator of Hsp90 ATPase, N-terminal/Activat
— OG7
TcYC6_0118110 ⚠
TAP42-like family, putative
— OG7
TcYC6_0053370 ⚠
ubiquitin-conjugating enzyme E2, putative
— OG7
TcYC6_0095490 ⚠
pdz domain containing protein, putative
— OG7
TcYC6_0121570 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0108610 ⚠
U-box domain protein, putative
— OG7
TcYC6_0054200 ⚠
6-phosphogluconolactonase, putative
— OG7
TcYC6_0117550 ⚠
NAD binding domain of 6-phosphogluconate dehy
— OG7
TcYC6_0113040 ⚠
eukaryotic translation initiation factor 4E (
— OG7
TcYC6_0073110 ⚠
choline/carnitine O-acetyltransferase, putati
— OG7
TcYC6_0065990 ⚠
iron superoxide dismutase A, mitochondrial
— OG7
TcYC6_0110890 ⚠
Flagellum attachment zone protein 19, putativ
— OG7
TcYC6_0061710 ⚠
PITH domain-containing protein
— OG7
TcYC6_0053430 ⚠
Alpha/beta hydrolase family, putative
— OG7
TcYC6_0032120 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0146170 ⚠
retrotransposon hot spot (RHS) protein, putat
— OG7
TcYC6_0104220 ⚠
hypothetical protein
— OG7
TcYC6_0065780 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0049760 ⚠
enoyl-CoA hydratase/isomerase family protein,
— OG7
TcYC6_0052370 ⚠
iron superoxide dismutase, putative
— OG7
TcYC6_0072350 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0053220 ⚠
exportin 1, putative
— OG7
TcYC6_0077340 ⚠
transcription elongation factor-like protein,
— OG7
TcYC6_0106350 ⚠
diphthine synthase, putative
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.