TcYC6_0119510

General negative regulator of transcription subunit 5
Trypanosoma cruzi Y C6 OG6: OG6_101346 OG7: OG7_0005130 88 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 88 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcYC6_0022750
hypothetical protein, conserved
— Both
TcYC6_0092000
cell differentiation protein, putative
— Both
TcYC6_0094210
ccr4-not transcription complex subunit
— Both
TcYC6_0061080
CCR4-NOT transcription complex subunit 2, put
— Both
TcYC6_0095890 ⚠
ubiquitin-protein ligase
— OG7
TcYC6_0101710 ⚠
protein kinase A regulatory subunit
— OG7
TcYC6_0049440 ⚠
cyclic nucleotide-binding protein
— OG7
TcYC6_0083610
hypothetical protein, conserved
— OG7
TcYC6_0066360 ⚠
structural maintenance of chromosome 3 protei
— OG7
TcYC6_0069650 ⚠
structural maintenance of chromosome (SMC) fa
— OG7
TcYC6_0091230 ⚠
target of rapamycin kinase 3
— OG7
TcYC6_0016900 ⚠
putative phosphatidylinositol 3-kinase
— OG7
TcYC6_0052770 ⚠
phosphatidylinositol 3-related kinase, putati
— OG7
TcYC6_0048910 ⚠
5'-3' exoribonuclease B, putative
— OG7
TcYC6_0115610 ⚠
tubulin-specific chaperone, putative
— OG7
TcYC6_0092100 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0055300 ⚠
WW domain containing protein, putative
— OG7
TcYC6_0043480
hypothetical protein, conserved
— OG7
TcYC6_0089660 ⚠
Guanine nucleotide exchange factor in Golgi t
— OG7
TcYC6_0126240 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0089530 ⚠
Sec7 domain containing protein, putative
— OG7
TcYC6_0073890 ⚠
translation initiation factor eIF2B subunit-l
— OG7
TcYC6_0064370 ⚠
translation initiation factor 2b, delta subun
— OG7
TcYC6_0093090
proteasome regulatory ATPase subunit 1, putat
— OG6
TcYC6_0094040
ATP-dependent DEAD/H RNA helicase, putative
— OG6
TcYC6_0120980 ⚠
hypothetical protein
— OG7
TcYC6_0081750 ⚠
dynein light chain p28, axonemal, putative
— OG7
TcYC6_0086080 ⚠
serine/threonine protein kinase
— OG7
TcYC6_0047340 ⚠
calcium/calmodulin-dependent protein kinase,
— OG7
TcYC6_0095280
hypothetical protein, conserved
— OG7
TcYC6_0079240 ⚠
Axonemal inner arm dynein light chain, putati
— OG7
TcYC6_0109490
hypothetical protein, conserved
— OG7
TcYC6_0103200
hypothetical protein
— OG7
TcYC6_0047690 ⚠
calcium/calmodulin-dependent protein kinase,
— OG7
TcYC6_0086020 ⚠
serine/threonine protein kinase, putative
— OG7
TcYC6_0055850 ⚠
Component of motile flagella 6
— OG7
TcYC6_0089970 ⚠
regulatory subunit of protein kinase a-like p
— OG7
TcYC6_0021890 ⚠
Microtubule-binding protein MIP-T3, putative
— OG7
TcYC6_0086030 ⚠
serine/threonine protein kinase
— OG7
TcYC6_0113920 ⚠
protein kinase
— OG7
TcYC6_0086070 ⚠
serine/threonine protein kinase
— OG7
TcYC6_0075720 ⚠
calcium/calmodulin-dependent protein kinase,
— OG7
TcYC6_0023220 ⚠
dynein arm light chain, putative
— OG7
TcYC6_0002180 ⚠
hypothetical protein
— OG7
TcYC6_0016180
dynein heavy chain, putative
— OG7
TcYC6_0018570
tc40 antigen-like, putative
— Both
TcYC6_0113530
WD domain, G-beta repeat, putative
— Both
TcYC6_0150680 ⚠
mucin TcMUCII, putative
— OG6
TcYC6_0152900 ⚠
mucin TcMUCII, putative
— OG6
TcYC6_0013770 ⚠
putative 5'-3' exoribonuclease A
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.