C4B63_23g240

Eukaryotic translation initiation factor 2 subunit alpha
Trypanosoma cruzi Dm28c 2018 OG6: OG6_101220 OG7: OG7_0006220 50 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Network view all shared interactors, plus up to 150 more
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Interactions 50 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_17g118 ⚠
SEC14-like protein 5
— OG7
C4B63_46g42 ⚠
conserved hypothetical protein
— Both
C4B63_46g35 ⚠
conserved hypothetical protein
— Both
C4B63_6g510 ⚠
Zinc finger MYND domain-containing protein 10
— Both
C4B63_4g242 ⚠
protein kinase A catalytic subunit 3
— OG6
C4B63_16g11 ⚠
5'-AMP-activated protein kinase subunit beta
— Both
C4B63_46g40 ⚠
conserved hypothetical protein
— Both
C4B63_46g38 ⚠
conserved hypothetical protein
— Both
C4B63_31g115
eukaryotic translation initiation factor 2 be
— Both
C4B63_17g119 ⚠
Phosphatidylinositol/phosphatidylcholine tran
— OG7
C4B63_18g39 ⚠
CRAL/TRIO, N-terminal domain/CRAL/TRIO domain
— OG7
C4B63_2g726 ⚠
CRAL/TRIO domain containing protein
— OG7
C4B63_40g22 ⚠
CRAL/TRIO domain containing protein
— OG7
C4B63_1g74 ⚠
eukaryotic translation initiation factor 2 su
— Both
C4B63_12g21 ⚠
Uncharacterized oxidoreductase YkwC
— OG7
C4B63_42g62 ⚠
dTDP-glucose 4,6-dehydratase
— OG7
C4B63_83g29 ⚠
ATP-dependent protease ATPase subunit HslU1
— OG7
C4B63_144g102c ⚠
U6 snRNA-associated Sm-like protein LSm6p
— OG7
C4B63_69g174c ⚠
U6 snRNA-associated Sm-like protein LSm6p
— OG7
C4B63_31g66
conserved hypothetical protein
— OG7
C4B63_271g80c ⚠
U6 snRNA-associated Sm-like protein LSm7p
— OG7
C4B63_43g1065c ⚠
U6 snRNA-associated Sm-like protein LSm7p
— OG7
C4B63_11g283c ⚠
U6 snRNA-associated Sm-like protein LSm8
— OG7
C4B63_2g1123c ⚠
small nuclear ribonucleoprotein Sm-F
— OG7
C4B63_72g86 ⚠
EEF1A lysine methyltransferase 4
— OG7
C4B63_42g63 ⚠
adenosine kinase
— Both
C4B63_29g6 ⚠
EEF1A lysine methyltransferase 4
— Both
C4B63_24g191
deoxyhypusine hydroxylase
— Both
C4B63_4g258
prolyl-tRNA synthetase
— Both
C4B63_27g229
cyclin 1
— Both
C4B63_39g344 ⚠
14-3-3 protein 1
— Both
C4B63_13g193 ⚠
cytosolic factor SEC14
— Both
C4B63_90g55 ⚠
TPR-repeat protein(fragment)
— Both
C4B63_79g87
phosphoglucomutase
— Both
C4B63_22g69
serine/threonine protein phosphatase 2A regul
— Both
C4B63_70g95 ⚠
14-3-3 protein 2
— Both
C4B63_42g242 ⚠
2-hydroxy-3-oxopropionate reductase
— Both
C4B63_7g332 ⚠
adenosine kinase
— Both
C4B63_33g10 ⚠
EEF1A lysine methyltransferase 4
— Both
C4B63_18g138
UV excision repair RAD23-like protein
— Both
C4B63_84g58 ⚠
conserved hypothetical protein
— Both
C4B63_391g10 ⚠
conserved hypothetical protein
— Both
C4B63_9g321
guide RNA associated protein, GAP1
— Both
C4B63_76g32
guide RNA associated protein, GAP2
— Both
C4B63_27g180 ⚠
ATP-dependent protease ATPase subunit HslU2
— Both
C4B63_24g197
nucleolar protein
— Both
C4B63_42g593c ⚠
small nuclear ribonucleoprotein Sm-E
— Both
C4B63_314g10 ⚠
5'-AMP-activated protein kinase subunit beta
— Both
C4B63_2g156 ⚠
protein kinase A catalytic subunit 3
— OG6
C4B63_5g417 ⚠
eukaryotic translation initiation factor 2 su
— Both
Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.