TcCLB.510743.10

ubiquitin-activating enzyme E1, putative
Trypanosoma cruzi CL Brener Esmeraldo-like OG6: OG6_100444 OG7: OG7_0003530 171 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 171 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcCLB.510761.70 ⚠
ubiquitin hydrolase, putative, cysteine pepti
— OG7
TcCLB.508277.360 ⚠
ubiquitin hydrolase, putative, cysteine pepti
— OG7
TcCLB.504153.300 ⚠
GTPase protein, putative
— OG7
TcCLB.511423.110 ⚠
hypothetical protein, conserved
— Both
TcCLB.510603.30 ⚠
hypothetical protein, conserved
— Both
TcCLB.503513.10 ⚠
casein kinase II, alpha chain, putative
— OG6
TcCLB.506743.170 ⚠
Met-10+ like-protein, putative
— Both
TcCLB.509967.80 ⚠
Programmed cell death protein 2, C-terminal p
— Both
TcCLB.509769.134 ⚠
Beta-lactamase superfamily domain containing
— Both
TcCLB.510533.20 ⚠
Beta-lactamase superfamily domain containing
— Both
TcCLB.503991.20 ⚠
Xaa-Pro aminopeptidase, putative
— Both
TcCLB.504019.9 ⚠
Importin-beta N-terminal domain/HEAT-like rep
— OG7
TcCLB.511529.9 ⚠
Importin-beta N-terminal domain/HEAT-like rep
— OG7
TcCLB.505943.20 ⚠
oxidoreductase, putative
— OG7
TcCLB.506885.416 ⚠
regulator of chromosome condensation (RCC1),
— OG7
TcCLB.510615.10 ⚠
hypothetical protein, conserved
— OG7
TcCLB.509267.50 ⚠
U5 small nuclear ribonucleoprotein component,
— OG7
TcCLB.506941.70 ⚠
hypothetical protein, conserved
— OG7
TcCLB.504203.29 ⚠
tRNA-dihydrouridine synthase 2, putative
— OG7
TcCLB.504147.190 ⚠
hypothetical protein, conserved
— OG7
TcCLB.506745.4 ⚠
hypothetical protein, conserved (fragment)
— OG7
TcCLB.510105.70 ⚠
hypothetical protein, conserved
— OG7
TcCLB.510053.70 ⚠
hypothetical protein, conserved
— OG7
TcCLB.506927.20 ⚠
hypothetical protein, conserved
— OG7
TcCLB.506265.180 ⚠
hypothetical protein, conserved
— OG7
TcCLB.508169.20 ⚠
elongation factor 2, putative
— OG7
TcCLB.506743.220 ⚠
hypothetical protein, conserved
— OG7
TcCLB.508213.9 ⚠
regulator of chromosome condensation, putativ
— OG7
TcCLB.506773.150 ⚠
hypothetical protein
— OG7
TcCLB.503489.10 ⚠
metallo-peptidase, Clan MC, Family M14, putat
— OG7
TcCLB.468941.9 ⚠
ATP-dependent DEAD/H RNA helicase, putative (
— OG7
TcCLB.510963.90 ⚠
elongation factor 2, putative
— OG7
TcCLB.504029.60 ⚠
hypothetical protein, conserved
— OG7
TcCLB.510313.20 ⚠
hypothetical protein, conserved
— OG7
TcCLB.503407.10 ⚠
hypothetical protein, conserved
— OG7
TcCLB.508323.120 ⚠
hypothetical protein, conserved
— OG7
TcCLB.508439.30 ⚠
regulator of chromosome condensation 1-like p
— OG7
TcCLB.506773.180 ⚠
regulator of chromatin condensation, putative
— OG7
TcCLB.508169.9 ⚠
elongation factor 2, putative (fragment)
— OG7
TcCLB.510601.30 ⚠
XRN 5'-3' exonuclease N-terminus, putative
— OG7
TcCLB.506691.14 ⚠
ATP-dependent DEAD/H RNA helicase, putative (
— OG7
TcCLB.510593.10 ⚠
Regulator of chromosome condensation (RCC1) r
— OG7
TcCLB.508211.60 ⚠
hypothetical protein, conserved
— OG7
TcCLB.506885.320 ⚠
TPR repeat/Tetratricopeptide repeat, putative
— OG7
TcCLB.506223.10 ⚠
hypothetical protein, conserved
— OG7
TcCLB.511627.100 ⚠
TPR-repeat protein, putative
— OG7
TcCLB.503677.4 ⚠
hypothetical protein, conserved
— OG7
TcCLB.510769.140 ⚠
hypothetical protein, conserved
— OG7
TcCLB.509127.110 ⚠
hypothetical protein, conserved
— OG7
TcCLB.509757.30 ⚠
stress-inducible protein STI1-like, putative
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.