LAMA_000737100

EF-1 guanine nucleotide exchange domain containing protein, putative

Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_101695 OG7: OG7_0003992 61 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 61 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
LAMA_000320600 ⚠ EF-1 guanine nucleotide exchange domain conta	—	OG6 LdBPK_340870.1 ↔ LdBPK_361490.1 OG6 Tb927.10.5840 ↔ Tb927.4.3590 OG7 Tb927.10.5840 ↔ Tb927.4.3590 OG7 LdBPK_340870.1 ↔ LdBPK_361490.1	Both
LAMA_000149700 ⚠ Glutathione S-transferase, N-terminal domain/	—	OG6 LdBPK_091020.1 ↔ LdBPK_361490.1 OG6 LdBPK_091020.1 ↔ LdBPK_340870.1 OG6 Tb927.11.13190 ↔ Tb927.4.3590 OG6 Tb927.11.13090 ↔ Tb927.4.3590 +8 more	Both
LAMA_000021900 ⚠ EF-1 guanine nucleotide exchange domain conta	—	OG6 LdBPK_340870.1 ↔ LdBPK_361490.1 OG6 Tb927.10.5840 ↔ Tb927.4.3590 OG7 Tb927.10.5840 ↔ Tb927.4.3590 OG7 LdBPK_340870.1 ↔ LdBPK_361490.1	Both
LAMA_000187400 ⚠ Glutathione S-transferase, N-terminal domain	—	OG7 Tb927.10.5840 ↔ Tb927.11.13090 OG7 Tb927.10.5840 ↔ Tb927.11.13190 OG7 LdBPK_091020.1 ↔ LdBPK_361490.1 OG7 LdBPK_091020.1 ↔ LdBPK_340870.1 +2 more	OG7
LAMA_000711100 ⚠ Glutathione S-transferase, N-terminal domain/	—	OG7 Tb927.10.5840 ↔ Tb927.11.13090 OG7 Tb927.10.5840 ↔ Tb927.11.13190 OG7 LdBPK_091020.1 ↔ LdBPK_361490.1 OG7 LdBPK_091020.1 ↔ LdBPK_340870.1 +2 more	OG7
LAMA_000051500 ⚠ KH domain containing protein, putative	—	OG6 Tb927.10.5840 ↔ Tb927.9.7070 OG7 Tb927.10.5840 ↔ Tb927.9.7070	Both
LAMA_000031800 ⚠ Hsp70 protein, putative	—	OG7 Tb927.10.5840 ↔ Tb927.7.710	OG7
LAMA_000494200 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_251670.1 ↔ LdBPK_361490.1 OG6 LdBPK_251670.1 ↔ LdBPK_340870.1 OG7 LdBPK_251670.1 ↔ LdBPK_361490.1 OG7 LdBPK_251670.1 ↔ LdBPK_340870.1	Both
LAMA_000525000 ⚠ Zn-finger in Ran binding protein and others/S	—	OG6 LdBPK_262390.1 ↔ LdBPK_361490.1 OG6 LdBPK_262390.1 ↔ LdBPK_340870.1 OG7 LdBPK_262390.1 ↔ LdBPK_361490.1 OG7 LdBPK_262390.1 ↔ LdBPK_340870.1	Both
LAMA_000200700 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_130700.1 ↔ LdBPK_361490.1 OG6 LdBPK_130700.1 ↔ LdBPK_340870.1 OG7 LdBPK_130700.1 ↔ LdBPK_361490.1 OG7 LdBPK_130700.1 ↔ LdBPK_340870.1	Both
LAMA_000336500 ⚠ 3' exoribonuclease family, domain 1/3' exorib	—	OG6 Tb927.10.5840 ↔ Tb927.10.7450 OG7 Tb927.10.5840 ↔ Tb927.10.7450	Both
LAMA_000019400 ⚠ hypothetical protein, conserved	—	OG6 Tb927.10.5840 ↔ Tb927.3.1300 OG7 Tb927.10.5840 ↔ Tb927.3.1300	Both
LAMA_000583300 ⚠ Hsp70 protein/MreB/Mbl protein, putative	—	OG6 Tb927.10.5840 ↔ Tb927.7.710	OG6
LAMA_000567600 ⚠ Hsp70 protein/MreB/Mbl protein, putative	—	OG6 Tb927.10.5840 ↔ Tb927.7.710 OG7 Tb927.10.5840 ↔ Tb927.7.710	Both
LAMA_000021200 ⚠ Hsp70 protein, putative	—	OG6 Tb927.10.5840 ↔ Tb927.7.710 OG7 Tb927.10.5840 ↔ Tb927.7.710	Both
LAMA_000514000 ⚠ Hsp70 protein/MreB/Mbl protein, putative	—	OG6 Tb927.10.5840 ↔ Tb927.7.710 OG7 Tb927.10.5840 ↔ Tb927.7.710	Both
LAMA_000019500 ⚠ hypothetical protein, conserved	—	OG6 Tb927.10.5840 ↔ Tb927.3.1300 OG7 Tb927.10.5840 ↔ Tb927.3.1300	Both
LAMA_000690100 ⚠ 3' exoribonuclease family, domain 1/3' exorib	—	OG6 Tb927.10.5840 ↔ Tb927.6.670 OG6 Tb927.10.5840 ↔ Tb927.11.16600 OG7 Tb927.10.5840 ↔ Tb927.6.670 OG7 Tb927.10.5840 ↔ Tb927.11.16600	Both
LAMA_000433200 ⚠ 3' exoribonuclease family, domain 1, putative	—	OG6 Tb927.10.5840 ↔ Tb927.6.670 OG6 Tb927.10.5840 ↔ Tb927.11.16600 OG7 Tb927.10.5840 ↔ Tb927.6.670 OG7 Tb927.10.5840 ↔ Tb927.11.16600	Both
LAMA_000406400 ⚠ OB-fold nucleic acid binding domain/tRNA synt	—	OG7 Tb927.10.5840 ↔ Tb927.4.2310 OG7 Tb927.4.2310 ↔ Tb927.4.3590	OG7
LAMA_000813600 ⚠ Hsp70 protein, putative	—	OG7 Tb927.10.5840 ↔ Tb927.7.710	OG7
LAMA_000510500 ⚠ Hsp70 protein, putative	—	OG7 Tb927.10.5840 ↔ Tb927.7.710	OG7
LAMA_000590700 ⚠ OB-fold nucleic acid binding domain/tRNA synt	—	OG7 Tb927.10.5840 ↔ Tb927.4.2310 OG7 Tb927.4.2310 ↔ Tb927.4.3590	OG7
LAMA_000356300 ⚠ 3' exoribonuclease family, domain 1, putative	—	OG7 Tb927.10.5840 ↔ Tb927.10.7450	OG7
LAMA_000012700 ⚠ 3' exoribonuclease family, domain 1, putative	—	OG7 Tb927.10.5840 ↔ Tb927.10.7450	OG7
LAMA_000378400 ⚠ RNA polymerase beta subunit/RNA polymerase Rp	—	OG7 Tb927.10.5840 ↔ Tb927.11.630	OG7
LAMA_000507200 ⚠ Conserved hypothetical ATP binding protein, p	—	OG7 Tb927.10.5840 ↔ Tb927.3.1150	OG7
LAMA_000286500 ⚠ Hsp70 protein, putative	—	OG7 Tb927.10.5840 ↔ Tb927.7.710	OG7
LAMA_000624500 ⚠ RNA polymerase beta subunit/RNA polymerase Rp	—	OG7 Tb927.10.5840 ↔ Tb927.11.630	OG7
LAMA_000088500 ⚠ Sec7 domain containing protein, putative	—	OG7 LdBPK_342220.1 ↔ LdBPK_361490.1 OG7 LdBPK_340870.1 ↔ LdBPK_342220.1	OG7
LAMA_000749000 ⚠ Guanine nucleotide exchange factor in Golgi t	—	OG7 LdBPK_342220.1 ↔ LdBPK_361490.1 OG7 LdBPK_340870.1 ↔ LdBPK_342220.1	OG7
LAMA_000239500 ⚠ tRNA synthetases class I (E and Q), catalytic	—	OG7 LdBPK_303290.1 ↔ LdBPK_361490.1 OG7 LdBPK_303290.1 ↔ LdBPK_340870.1	OG7
LAMA_000757500 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_340870.1 ↔ LdBPK_343240.1 OG6 LdBPK_343240.1 ↔ LdBPK_361490.1 OG7 LdBPK_343240.1 ↔ LdBPK_361490.1 OG7 LdBPK_340870.1 ↔ LdBPK_343240.1	Both
LAMA_000618000 ⚠ tRNA synthetases class I (E and Q), catalytic	—	OG6 LdBPK_303290.1 ↔ LdBPK_361490.1 OG6 LdBPK_303290.1 ↔ LdBPK_340870.1 OG7 LdBPK_303290.1 ↔ LdBPK_361490.1 OG7 LdBPK_303290.1 ↔ LdBPK_340870.1	Both
LAMA_000553800 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_272380.1 ↔ LdBPK_361490.1 OG6 LdBPK_272380.1 ↔ LdBPK_340870.1 OG7 LdBPK_272380.1 ↔ LdBPK_361490.1 OG7 LdBPK_272380.1 ↔ LdBPK_340870.1	Both
LAMA_000766700 ⚠ WD domain, G-beta repeat/Coatomer WD associat	—	OG6 LdBPK_344140.1 ↔ LdBPK_361490.1 OG6 LdBPK_340870.1 ↔ LdBPK_344140.1 OG7 LdBPK_344140.1 ↔ LdBPK_361490.1 OG7 LdBPK_340870.1 ↔ LdBPK_344140.1	Both
LAMA_000391000 ⚠ Adaptin N terminal region/Coatomer beta C-ter	—	OG6 LdBPK_201390.1 ↔ LdBPK_361490.1 OG6 LdBPK_201390.1 ↔ LdBPK_340870.1 OG7 LdBPK_201390.1 ↔ LdBPK_361490.1 OG7 LdBPK_201390.1 ↔ LdBPK_340870.1	Both
LAMA_000790400 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_352430.1 ↔ LdBPK_361490.1 OG6 LdBPK_340870.1 ↔ LdBPK_352430.1 OG7 LdBPK_352430.1 ↔ LdBPK_361490.1 OG7 LdBPK_340870.1 ↔ LdBPK_352430.1	Both
LAMA_000493800 ⚠ ER-Golgi trafficking TRAPP I complex 85 kDa s	—	OG6 LdBPK_251630.1 ↔ LdBPK_361490.1 OG6 LdBPK_251630.1 ↔ LdBPK_340870.1 OG7 LdBPK_251630.1 ↔ LdBPK_361490.1 OG7 LdBPK_251630.1 ↔ LdBPK_340870.1	Both
LAMA_000581500 ⚠ Adaptin N terminal region/Coatomer gamma subu	—	OG6 LdBPK_282820.1 ↔ LdBPK_361490.1 OG6 LdBPK_282820.1 ↔ LdBPK_340870.1 OG7 LdBPK_282820.1 ↔ LdBPK_361490.1 OG7 LdBPK_282820.1 ↔ LdBPK_340870.1	Both
LAMA_000615900 ⚠ Eukaryotic translation initiation factor 3 su	—	OG6 LdBPK_303080.1 ↔ LdBPK_361490.1 OG6 LdBPK_303080.1 ↔ LdBPK_340870.1 OG7 LdBPK_303080.1 ↔ LdBPK_361490.1 OG7 LdBPK_303080.1 ↔ LdBPK_340870.1	Both
LAMA_000391100 ⚠ hypothetical protein, conserved	—	OG6 Tb927.1.2580 ↔ Tb927.10.5840 OG7 Tb927.1.2580 ↔ Tb927.10.5840	Both
LAMA_000747800 ⚠ Guanine nucleotide exchange factor in Golgi t	—	OG6 LdBPK_342220.1 ↔ LdBPK_361490.1 OG6 LdBPK_340870.1 ↔ LdBPK_342220.1 OG7 LdBPK_342220.1 ↔ LdBPK_361490.1 OG7 LdBPK_340870.1 ↔ LdBPK_342220.1	Both
LAMA_000719200 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_332380.1 ↔ LdBPK_361490.1 OG6 LdBPK_332380.1 ↔ LdBPK_340870.1 OG7 LdBPK_332380.1 ↔ LdBPK_361490.1 OG7 LdBPK_332380.1 ↔ LdBPK_340870.1	Both
LAMA_000386600 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_200940.1 ↔ LdBPK_361490.1 OG6 LdBPK_200940.1 ↔ LdBPK_340870.1 OG7 LdBPK_200940.1 ↔ LdBPK_361490.1 OG7 LdBPK_200940.1 ↔ LdBPK_340870.1	Both
LAMA_000147700 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_090810.1 ↔ LdBPK_361490.1 OG6 LdBPK_090810.1 ↔ LdBPK_340870.1 OG7 LdBPK_090810.1 ↔ LdBPK_361490.1 OG7 LdBPK_090810.1 ↔ LdBPK_340870.1	Both
LAMA_000374300 ⚠ FtsJ-like methyltransferase, putative	—	OG6 Tb927.10.7940 ↔ Tb927.4.3590 OG6 Tb927.10.5840 ↔ Tb927.10.7940 OG7 Tb927.10.5840 ↔ Tb927.10.7940 OG7 Tb927.10.7940 ↔ Tb927.4.3590	Both
LAMA_000484600 ⚠ RNA polymerase beta subunit/RNA polymerase Rp	—	OG6 Tb927.10.5840 ↔ Tb927.11.630 OG7 Tb927.10.5840 ↔ Tb927.11.630	Both
LAMA_000773400 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_340870.1 ↔ LdBPK_350610.1 OG6 LdBPK_350610.1 ↔ LdBPK_361490.1 OG7 LdBPK_350610.1 ↔ LdBPK_361490.1 OG7 LdBPK_340870.1 ↔ LdBPK_350610.1	Both
LAMA_000377800 ⚠ Eukaryotic translation initiation factor 3 su	—	OG6 LdBPK_340870.1 ↔ LdBPK_367320.1 OG6 LdBPK_361490.1 ↔ LdBPK_367320.1 OG7 LdBPK_340870.1 ↔ LdBPK_367320.1 OG7 LdBPK_361490.1 ↔ LdBPK_367320.1	Both

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