LbrM.22.0110

GMP synthase [glutamine-hydrolysing]
Leishmania braziliensis MHOM/BR/75/M2904 OG6: OG6_100862 OG7: OG7_0002018 176 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 176 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LbrM.28.1530 ⚠
hypothetical protein, conserved
— OG7
LbrM.10.0200
Mitogen-activated protein kinase 10, putative
— OG6
LbrM.18.1050
UDP-glucose pyrophosphorylase
— Both
LbrM.31.1280
biotin/lipoate protein ligase-like protein
— Both
LbrM.34.4160 ⚠
Protein of unknown function (DUF2009), putati
— Both
LbrM.25.1580
hypothetical protein, conserved
— Both
LbrM.34.0070 ⚠
pyruvate kinase, putative (fragment)
— Both
LbrM.13.1300
Gamma-soluble NSF attachment protein (SNAP-ga
— Both
LbrM.31.1820
diphthine synthase-like protein
— Both
LbrM.17.1380 ⚠
hypothetical protein, conserved
— Both
LbrM.32.1860 ⚠
protein phosphatase 2C, putative
— OG6
LbrM.26.2630 ⚠
6-phosphogluconolactonase
— Both
LbrM.34.0060 ⚠
pyruvate kinase
— Both
LbrM.05.0310 ⚠
monothiol glutaredoxin, putative
— Both
LbrM.32.1050
ubiquitin-conjugating enzyme protein, putativ
— Both
LbrM.35.6500
Sucrase/ferredoxin-like, putative
— Both
LbrM.34.0040 ⚠
pyruvate kinase
— Both
LbrM.26.0350 ⚠
C-1-tetrahydrofolate synthase, cytoplasmic, p
— Both
LbrM.30.0180 ⚠
2-hydroxy-3-oxopropionate reductase, putative
— Both
LbrM.25.1070
TAP42-like family, putative
— Both
LbrM.25.1250
NPL4 family, putative
— Both
LbrM.34.0810 ⚠
aspartate aminotransferase, putative
— Both
LbrM.31.0730
amino acid transporter aATP11, putative
— OG6
LbrM.10.0310
isocitrate dehydrogenase [NADP], mitochondria
— Both
LbrM.35.0680 ⚠
Elongation factor G1, mitochondrial, putative
— Both
LbrM.20.4840 ⚠
hypothetical protein, conserved
— Both
LbrM.34.4450 ⚠
Co-chaperone protein P23
— Both
LbrM.18.0310 ⚠
dephospho-CoA kinase, putative
— Both
LbrM.30.0740
pdz domain containing protein, putative
— Both
LbrM.34.1170 ⚠
thioredoxin-like protein
— Both
LbrM.16.0750
transaldolase, putative
— Both
LbrM.27.2210
branched-chain amino acid aminotransferase, p
— Both
LbrM.04.0010
phosphoacetylglucosamine mutase-like gene
— Both
LbrM.34.0400
enoyl-CoA hydratase/isomerase family protein,
— Both
LbrM.27.2520 ⚠
GTP binding protein, putative
— Both
LbrM.23.1720
alanine racemase, putative
— Both
LbrM.33.3090 ⚠
transcription elongation factor-like protein
— Both
LbrM.10.1490
hypothetical protein, conserved
— OG7
LbrM.32.3400 ⚠
Serine hydrolase (FSH1)/50S ribosome-binding
— OG7
LbrM.27.1970 ⚠
GTP binding protein, putative
— OG7
LbrM.34.3430 ⚠
zinc finger protein, putative
— OG7
LbrM.28.2160 ⚠
Elongation factor G 2, mitochondrial, putativ
— OG7
LbrM.17.1260 ⚠
5'-3' exoribonuclease B, putative
— OG7
LbrM.21.0210 ⚠
serine/threonine-protein kinase-like protein
— OG7
LbrM.32.3910 ⚠
3-hydroxyisobutyryl-coenzyme a hydrolase-like
— OG7
LbrM.27.2620 ⚠
aldo-keto reductase-like protein
— OG7
LbrM.35.1020 ⚠
SNF1-related protein kinases, putative
— OG7
LbrM.32.2690 ⚠
Cid1 family poly A polymerase, putative
— OG7
LbrM.33.1980 ⚠
protein kinase, putative
— OG7
LbrM.34.4260 ⚠
Spindle assembly abnormal protein 6 homolog
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.