LmjF.18.0650

PA26 p53-induced protein (sestrin), putative
Leishmania major strain Friedlin OG6: OG6_141922 OG7: OG7_0006056 83 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 83 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LmjF.10.0890 ⚠
FKBP-type peptidyl-prolyl cis-trans isomerase
— OG7
LmjF.36.2930 ⚠
predicted zinc finger protein
— OG7
LmjF.20.1370 ⚠
pumilio protein 9, putative
— OG7
LmjF.35.2450 ⚠
ubiquitin-protein ligase, putative
— OG7
LmjF.23.0120 ⚠
Concanavalin A-like lectin/glucanases superfa
— OG7
LmjF.01.0030 ⚠
Kinesin-13 1, putative
— OG7
LmjF.36.0230 ⚠
peptidyl-prolyl cis-trans isomerase, putative
— OG7
LmjF.22.0060 ⚠
transcription factor-like protein
— OG7
LmjF.21.1295 ⚠
Ring finger domain containing protein, putati
— OG7
LmjF.13.1610 ⚠
Kinesin-13 5, putative
— OG7
LmjF.31.0290 ⚠
Kinesin-13 4, putative
— OG7
LmjF.06.0050 ⚠
pumilio/PUF RNA binding protein 5, putative
— OG7
LmjF.21.1680 ⚠
pumillio protein 3, putative
— OG7
LmjF.36.6430 ⚠
protein transport protein Sec23-like protein
— OG7
LmjF.32.2150 ⚠
hypothetical protein, conserved
— OG7
LmjF.33.2570 ⚠
metallo-peptidase, Clan MF, Family M17
— OG7
LmjF.12.0280
ornithine decarboxylase, putative
— Both
LmjF.11.1120
hypothetical protein, conserved
— Both
LmjF.26.2350
hypothetical protein, conserved
— Both
LmjF.23.0490
5'-AMP-activated protein kinase subunit beta,
— Both
LmjF.35.0830 ⚠
NADH-dependent fumarate reductase-like protei
— Both
LmjF.17.0030 ⚠
Ring finger domain containing protein, putati
— OG7
LmjF.26.1160 ⚠
RNA pseudouridylate synthase, putative
— OG7
LmjF.04.0250 ⚠
RNA pseudouridylate synthase-like protein
— OG7
LmjF.34.0310 ⚠
tRNA pseudouridine synthase, putative
— OG7
LmjF.09.0350 ⚠
Ring finger domain containing protein, putati
— OG7
LmjF.27.1200 ⚠
RING-H2 zinc finger, putative
— OG7
LmjF.36.1720 ⚠
neurobeachin/beige protein, putative
— OG7
LmjF.36.4370 ⚠
ubiquitin protein ligase, putative
— OG7
LmjF.19.1020 ⚠
tRNA pseudouridine synthase A-like protein
— OG7
LmjF.23.1570 ⚠
neutral sphingomyelinase activation associate
— OG7
LmjF.13.0130 ⚠
Kinesin-13 2
— OG7
LmjF.33.2980
hypothetical protein, conserved
— Both
LmjF.25.0340 ⚠
Ring finger domain containing protein, putati
— OG7
LmjF.12.0380 ⚠
pumillio protein 4, putative
— OG7
LmjF.34.3960 ⚠
HECT-domain (ubiquitin-transferase), putative
— OG7
LmjF.36.0050 ⚠
PUF1, putative
— OG7
LmjF.26.0420 ⚠
pseudouridylate synthase-like protein
— OG7
LmjF.19.1530 ⚠
FK506-binding protein (FKBP)-type peptidyl-pr
— OG7
LmjF.20.1365 ⚠
pumillio protein 9, putative
— OG7
LmjF.19.0970 ⚠
peptidyl-prolyl cis-trans isomerase, macropha
— OG7
LmjF.22.1430 ⚠
fk506-binding protein 1-like protein
— OG7
LmjF.15.0360 ⚠
RNA pseudouridylate synthase, putative
— Both
LmjF.19.0750
hypothetical protein, conserved
— Both
LmjF.30.1850
phosphatidylinositol kinase, putative
— Both
LmjF.29.1240 ⚠
Hsp70 protein/TPR repeat, putative
— Both
LmjF.24.0640 ⚠
Kinesin-13 3, putative
— Both
LmjF.07.0800 ⚠
flavoprotein subunit-like protein
— Both
LmjF.36.5620
isoleucyl-tRNA synthetase, putative
— Both
LmjF.18.1420 ⚠
pumilio protein 2, putative
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.