LmjF.28.2370

serine hydroxymethyltransferase (SHMT-L)
Leishmania major strain Friedlin OG6: OG6_100262 OG7: OG7_0003031 122 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 122 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LmjF.04.0330 ⚠
mitochondrial exoribonuclease DSS-1, putative
— OG7
LmjF.29.2540 ⚠
NOL1/NOP2/sun family, putative
— Both
LmjF.36.2170 ⚠
NOL1/NOP2/sun family, putative
— Both
LmjF.29.2110 ⚠
UDP-glucose:glycoprotein glucosyltransferase,
— Both
LmjF.36.0070 ⚠
stress-inducible protein STI1 homolog
— OG6
LmjF.27.2390 ⚠
TPR-repeat protein, putative
— OG6
LmjF.20.1710 ⚠
tRNA (Uracil-5-)-methyltransferase, putative
— Both
LmjF.05.0820 ⚠
hypothetical protein, conserved
— Both
LmjF.25.0170 ⚠
cleavage and polyadenylation specificity fact
— Both
LmjF.22.1540 ⚠
alanyl-tRNA synthetase, putative
— Both
LmjF.36.5620 ⚠
isoleucyl-tRNA synthetase, putative
— Both
LmjF.36.4040 ⚠
hypothetical protein, conserved
— Both
LmjF.30.0460 ⚠
aspartyl-tRNA synthetase, putative
— Both
LmjF.21.0895 ⚠
aspartyl-tRNA synthetase, putative
— Both
LmjF.28.0450 ⚠
DIS3-like exonuclease, putative
— Both
LmjF.23.0110 ⚠
GDP-mannose pyrophosphorylase
— Both
LmjF.30.0730 ⚠
co-chaperone GrpE, putative
— Both
LmjF.30.3240 ⚠
glutamyl-tRNA synthetase, putative
— Both
LmjF.29.0060 ⚠
tryptophanyl-tRNA synthetase, putative
— Both
LmjF.14.1370 ⚠
tyrosyl-tRNA synthetase, putative
— Both
LmjF.32.3980 ⚠
Gar1/Naf1 RNA binding region, putative
— Both
LmjF.17.0350 ⚠
dihydrouridine synthase (Dus), putative
— Both
LmjF.21.0490 ⚠
DnaJ protein, putative
— Both
LmjF.27.2400 ⚠
heat shock protein DNAJ, putative
— Both
LmjF.36.5590 ⚠
adenylyl cyclase-associated protein, putative
— Both
LmjF.03.0910 ⚠
inorganic pyrophosphatase, putative
— Both
LmjF.11.0210 ⚠
acidocalcisomal pyrophosphatase
— Both
LmjF.33.1120 ⚠
hypothetical protein, conserved
— Both
LmjF.11.0630 ⚠
metallo-peptidase, Clan MF, Family M17
— OG7
LmjF.11.0620 ⚠
metallo-peptidase, Clan MF, Family M17
— OG7
LmjF.28.0330 ⚠
rrp44p homologue, putative
— OG7
LmjF.35.2950 ⚠
pentatricopeptide repeat domain containing pr
— OG7
LmjF.21.0040 ⚠
hypothetical protein, conserved
— OG7
LmjF.21.0030 ⚠
hypothetical protein, conserved
— OG7
LmjF.24.1340 ⚠
translation initiation factor IF-2, putative
— OG7
LmjF.30.0700 ⚠
nuclear movement protein, putative
— OG7
LmjF.30.0735 ⚠
heat shock protein grpe
— OG7
LmjF.36.0470 ⚠
dihydrouridine synthase domain protein-like p
— OG7
LmjF.34.1140 ⚠
dihydrouridine synthase (Dus), putative
— OG7
LmjF.31.1930 ⚠
dihydrouridine synthase (Dus), putative
— OG7
LmjF.15.1440 ⚠
glutaminyl-tRNA synthetase, putative
— OG7
LmjF.31.1130 ⚠
amidohydrolase, putative
— OG7
LmjF.18.1110 ⚠
Multisite-specific tRNA:(cytosine-C(5))-methy
— OG7
LmjF.17.1130 ⚠
NOL1/NOP2/sun family, putative
— OG7
LmjF.29.1970 ⚠
hypothetical protein, unknown function
— OG7
LmjF.33.1400 ⚠
STE/STE11 serine/threonine-protein kinase, pu
— OG7
LmjF.15.1220 ⚠
DnaJ domain/DnaJ central domain containing pr
— OG7
LmjF.25.1100 ⚠
DNAj-like protein
— OG7
LmjF.35.2980 ⚠
chaperone protein DnaJ, putative
— OG7
LmjF.33.0900 ⚠
dnaj chaperone-like protein
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.