LmjF.36.3910

S-adenosylhomocysteine hydrolase
Leishmania major strain Friedlin OG6: OG6_100715 OG7: OG7_0003269 54 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 54 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LmjF.25.0750
protein phosphatase 2C, putative
— OG6
LmjF.15.1080 ⚠
tryparedoxin peroxidase
— Both
LmjF.15.1040 ⚠
tryparedoxin peroxidase
— Both
LmjF.08.1130 ⚠
phosphoribosylpyrophosphate synthetase
— Both
LmjF.06.0370
glutamine synthetase, putative
— Both
LmjF.35.3230 ⚠
cystathione gamma lyase, putative
— Both
LmjF.23.0340
(H+)-ATPase G subunit, putative
— Both
LmjF.23.0110
GDP-mannose pyrophosphorylase
— Both
LmjF.15.1120 ⚠
tryparedoxin peroxidase
— Both
LmjF.23.0040 ⚠
peroxidoxin
— Both
LmjF.15.1010
glutamate dehydrogenase
— Both
LmjF.05.0970
3-mercaptopyruvate sulfurtransferase
— Both
LmjF.03.0200
delta-1-pyrroline-5-carboxylate dehydrogenase
— Both
LmjF.33.2610 ⚠
Mitochondrial-processing peptidase subunit al
— Both
LmjF.26.0030
pyridoxal phosphate containing glycine decarb
— Both
LmjF.36.2360
tyrosine aminotransferase
— Both
LmjF.21.0340 ⚠
mitochondrial processing peptidase alpha subu
— OG7
LmjF.13.0870 ⚠
mitochondrial processing peptidase alpha subu
— OG7
LmjF.32.3970 ⚠
cAMP response protein 1, putative
— OG7
LmjF.34.2820 ⚠
regulatory subunit of protein kinase a-like p
— OG7
LmjF.15.1200 ⚠
STE group serine/threonine-protein kinase, pu
— OG7
LmjF.08.0510 ⚠
ribose-phosphate pyrophosphokinase, putative
— OG7
LmjF.33.1930 ⚠
phosphoribosylpyrophosphate synthetase, putat
— OG7
LmjF.30.3240 ⚠
glutamyl-tRNA synthetase, putative
— OG7
LmjF.36.5390 ⚠
phosphoribosylpyrophosphate synthetase, putat
— OG7
LmjF.36.4450 ⚠
mitochondrial intermediate peptidase, putativ
— OG7
LmjF.27.0860
WD domain, G-beta repeat, putative
— OG7
LmjF.28.2430
Vacuolar proton pump subunit B, putative
— Both
LmjF.36.3590 ⚠
cysteine synthase
— OG6
LmjF.30.0610
nitrate reductase, putative
— OG6
LmjF.19.1440 ⚠
mitogen-activated protein kinase 4
— OG6
LmjF.07.0805
N-acetylglucosamine-phosphate mutase, putativ
— Both
LmjF.33.1380 ⚠
mitogen-activated protein kinase 11, putative
— OG6
LmjF.36.1760
aldehyde dehydrogenase, putative
— Both
LmjF.02.0040 ⚠
Xaa-Pro aminopeptidase, putative
— Both
LmjF.25.2430 ⚠
Xaa-Pro aminopeptidase, putative
— Both
LmjF.26.1570 ⚠
thimet oligopeptidase, putative
— Both
LmjF.27.2660 ⚠
peptidyl dipeptidase, putative
— Both
LmjF.02.0740 ⚠
dipeptylcarboxypeptidase, putative
— Both
LmjF.01.0830 ⚠
metallo-peptidase, Clan MA(E), Family M3
— Both
LmjF.36.3100
ATP synthase, putative
— Both
LmjF.17.0250 ⚠
cystathionine beta-synthase
— Both
LmjF.13.0160 ⚠
protein kinase A regulatory subunit
— Both
LmjF.11.1000
pyruvate phosphate dikinase, putative
— Both
LmjF.14.1360
inositol-3-phosphate synthase
— Both
LmjF.34.0080
glucose-6-phosphate 1-dehydrogenase, putative
— Both
LmjF.33.2300
udp-glc 4'-epimerase, putative
— Both
LmjF.15.1060 ⚠
tryparedoxin peroxidase
— Both
LmjF.34.3670
vacuolar ATP synthase catalytic subunit A, pu
— Both
LmjF.15.1440 ⚠
glutaminyl-tRNA synthetase, putative
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.