TcCLB.509761.10

Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative
Trypanosoma cruzi CL Brener Esmeraldo-like OG6: OG6_102309 OG7: OG7_0007246 121 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 121 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcCLB.503479.70 ⚠
hook complex protein, conserved
— OG7
TcCLB.503885.90
WD domain, G-beta repeat/PFU (PLAA family ubi
— Both
TcCLB.511421.110 ⚠
developmentally regulated phosphoprotein, put
— Both
TcCLB.511693.10
hypothetical protein
— Both
TcCLB.506857.110
Uncharacterised protein family UPF0066, putat
— Both
TcCLB.509007.20
hypothetical protein, conserved
— Both
TcCLB.511911.21 ⚠
hypothetical protein, conserved
— Both
TcCLB.510777.20 ⚠
aspartyl-tRNA synthetase, putative
— Both
TcCLB.509967.30 ⚠
aspartyl-tRNA synthetase, putative
— Both
TcCLB.503589.10
GDP-mannose pyrophosphorylase
— Both
TcCLB.511555.60
ubiquitin ligase, putative
— Both
TcCLB.506733.60
N(2), N(2)-dimethylguanosine tRNA methyltrans
— Both
TcCLB.511067.10
tubulin folding cofactor D, putative
— Both
TcCLB.507925.69
hypothetical protein, conserved
— Both
TcCLB.506869.60 ⚠
protein kinase PK4, putative
— Both
TcCLB.504427.200 ⚠
poly(A)-specific ribonuclease PARN, putative
— Both
TcCLB.506251.100 ⚠
poly(A)-specific ribonuclease PARN, putative
— Both
TcCLB.506859.70
guide RNA associated protein, GAP2, putative
— Both
TcCLB.508347.120 ⚠
hypothetical protein, conserved
— Both
TcCLB.503689.40 ⚠
hypothetical protein, conserved
— Both
TcCLB.508181.140 ⚠
inorganic pyrophosphatase, putative
— Both
TcCLB.503613.60 ⚠
acidocalcisomal pyrophosphatase, putative
— Both
TcCLB.511001.190
vacuolar ATP synthase subunit d, putative
— Both
TcCLB.509777.100 ⚠
ubiquitin-activating enzyme, putative
— Both
TcCLB.507993.280 ⚠
zinc-finger of a C2HC-type/Double zinc ribbon
— Both
TcCLB.511545.140 ⚠
hypothetical protein, conserved
— OG6
TcCLB.504153.140
metallo-peptidase, Clan MF, Family M17
— OG7
TcCLB.503893.140 ⚠
zinc-finger of a C2HC-type, putative
— OG7
TcCLB.504203.50 ⚠
zinc-finger of a C2HC-type, putative
— OG7
TcCLB.508387.30 ⚠
zinc-finger of a C2HC-type, putative
— OG7
TcCLB.510963.50 ⚠
6-phosphofructo-2-kinase/fructose-2,6-bisphos
— OG7
TcCLB.511627.100 ⚠
TPR-repeat protein, putative
— OG7
TcCLB.506673.60 ⚠
Adaptor protein complex AP-3 subunit beta-3
— OG7
TcCLB.510101.150 ⚠
adaptin-related protein-like, putative
— OG7
TcCLB.504137.60 ⚠
beta adaptin, putative
— OG7
TcCLB.511585.130 ⚠
ubiquitin activating enzyme, putative
— OG7
TcCLB.504153.310 ⚠
heat shock protein, putative
— OG7
TcCLB.506591.4 ⚠
heat shock protein 90, putative
— OG7
TcCLB.503811.10 ⚠
heat shock protein 90, putative
— OG7
TcCLB.427247.10 ⚠
CMGC/DYRK protein kinase, putative
— OG7
TcCLB.508675.9 ⚠
CMGC/DYRK protein kinase, putative (fragment)
— OG7
TcCLB.506519.60 ⚠
CMGC/CLK family protein kinase, putative
— OG7
TcCLB.506739.190 ⚠
CMGC/DYRK protein kinase, putative
— OG7
TcCLB.480785.10 ⚠
serine/threonine kinase, putative, CMGC/DYRK
— OG7
TcCLB.510431.140 ⚠
dual specificity tyrosine-phosphorylation-reg
— OG7
TcCLB.511737.10 ⚠
small glutamine-rich tetratricopeptide repeat
— OG7
TcCLB.503579.110 ⚠
pseudouridylate synthase I, putative
— OG7
TcCLB.511751.180 ⚠
pseudouridine synthase A-like protein, putati
— OG7
TcCLB.506147.30 ⚠
synaptojanin (N-terminal domain), putative, i
— OG7
TcCLB.510749.40 ⚠
cysteine peptidase, Clan CA, family C19, puta
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.