LbrM.20.0010

mitochondrial malate dehydrogenase
Leishmania braziliensis MHOM/BR/75/M2904 OG6: OG6_101212 OG7: OG7_0004751 67 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 67 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LbrM.04.0630 ⚠
spermidine synthase, putative
— Both
LbrM.20.5920 ⚠
amidohydrolase, putative
— Both
LbrM.13.0880 ⚠
NADH-cytochrome b5 reductase, putative
— OG7
LbrM.32.2570 ⚠
cytochrome-b5 reductase, putative
— OG7
LbrM.27.0810 ⚠
reductase, putative
— OG7
LbrM.33.3140 ⚠
cysteine peptidase, Clan CA, family C51, puta
— OG7
LbrM.31.1330 ⚠
amidohydrolase, putative
— Both
LbrM.05.0350 ⚠
trypanothione reductase
— Both
LbrM.20.5910 ⚠
amidohydrolase, putative
— Both
LbrM.23.1970 ⚠
cytochrome c oxidase subunit V
— OG7
LbrM.14.0960 ⚠
sodium/hydrogen exchanger, putative
— Both
LbrM.30.1491 ⚠
N-acyl-L-amino acid amidohydrolase, putative
— Both
LbrM.09.0850 ⚠
oligopeptidase b
— Both
LbrM.06.0320 ⚠
oligopeptidase B-like protein, serine peptida
— Both
LbrM.20.5930 ⚠
amidohydrolase, putative
— Both
LbrM.19.0470 ⚠
metallo-peptidase, Clan MG, Family M24
— Both
LbrM.25.1930 ⚠
AGC essential kinase 1
— OG6
LbrM.35.7100 ⚠
prolyl endopeptidase
— OG7
LbrM.29.0500 ⚠
hypothetical protein, conserved
— OG7
LbrM.15.0540 ⚠
ecotin, putative
— OG7
LbrM.15.0340 ⚠
Ecotin-like protein
— OG7
LbrM.22.1510 ⚠
ser/thr protein phosphatase, putative
— OG7
LbrM.28.1700 ⚠
ATP-dependent RNA helicase FAL1, putative
— OG7
LbrM.01.0740 ⚠
Eukaryotic initiation factor 4A-1
— OG7
LbrM.35.4690 ⚠
mitochondrial intermediate peptidase, putativ
— OG7
LbrM.13.0500 ⚠
Metallopeptidase family M24, putative
— OG7
LbrM.07.0190 ⚠
protein phosphatase 2A, regulatory subunit B,
— Both
LbrM.20.3080 ⚠
ruvb-like 1 DNA helicase, putative
— OG7
LbrM.33.3110 ⚠
cysteine peptidase, Clan CA, family C51, puta
— OG7
LbrM.26.0120 ⚠
adenine phosphoribosyltransferase
— OG7
LbrM.30.2790 ⚠
chaperonin HSP60/CNP60, putative
— OG7
LbrM.23.0490 ⚠
trypanothione synthetase, putative
— OG7
LbrM.34.3350 ⚠
replication factor A protein 3, putative
— OG7
LbrM.19.0050 ⚠
NADH-cytochrome b5 reductase-like protein
— OG7
LbrM.27.2010 ⚠
trypanothione synthetase
— Both
LbrM.29.2850 ⚠
inosine-adenosine-guanosine-nucleosidehydrola
— Both
LbrM.25.1700 ⚠
succinyl-CoA synthetase alpha subunit, putati
— Both
LbrM.25.1710 ⚠
succinyl-CoA synthetase alpha subunit, putati
— Both
LbrM.35.2250 ⚠
chaperonin HSP60, mitochondrial precursor
— Both
LbrM.28.3070 ⚠
cytosolic malate dehydrogenase
— Both
LbrM.15.0050 ⚠
cytochrome-b5 reductase, putative
— Both
LbrM.22.0710 ⚠
NADH-cytochrome b5 reductase, putative
— Both
LbrM.35.3170 ⚠
succinyl-CoA ligase [GDP-forming] beta-chain,
— Both
LbrM.32.2030 ⚠
Chaperonin HSP60, mitochondrial
— Both
LbrM.15.0550 ⚠
ecotin, putative
— Both
LbrM.29.2080 ⚠
Present in the outer mitochondrial membrane p
— Both
LbrM.30.1050 ⚠
hypothetical protein, conserved
— Both
LbrM.06.1050 ⚠
deoxyribose-phosphate aldolase, putative
— Both
LbrM.17.0570 ⚠
bis(5'-nucleosyl)-tetraphosphatase, symmetric
— Both
LbrM.22.0480 ⚠
peptidyl-prolyl cis-trans isomerase, putative
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.