TcYC6_0061720

translation initiation factor EIF-2b alpha subunit, putative
Trypanosoma cruzi Y C6 OG6: OG6_102141 OG7: OG7_0001817 77 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 77 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcYC6_0040230 ⚠
AAA ATPase, putative
— Both
TcYC6_0052770 ⚠
phosphatidylinositol 3-related kinase, putati
— OG7
TcYC6_0101710 ⚠
protein kinase A regulatory subunit
— OG7
TcYC6_0021890 ⚠
Microtubule-binding protein MIP-T3, putative
— OG7
TcYC6_0049440 ⚠
cyclic nucleotide-binding protein
— OG7
TcYC6_0115610 ⚠
tubulin-specific chaperone, putative
— OG7
TcYC6_0083610 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0023220 ⚠
dynein arm light chain, putative
— OG7
TcYC6_0069650 ⚠
structural maintenance of chromosome (SMC) fa
— OG7
TcYC6_0002180 ⚠
hypothetical protein
— OG7
TcYC6_0091230 ⚠
target of rapamycin kinase 3
— OG7
TcYC6_0076120 ⚠
hypothetical protein, conserved
— Both
TcYC6_0083620 ⚠
Nucleoporin NUP76
— Both
TcYC6_0021660 ⚠
structural maintenance of chromosome protein
— Both
TcYC6_0052760 ⚠
Microtubule-binding protein MIP-T3, putative
— Both
TcYC6_0127460 ⚠
fibrillarin, putative
— Both
TcYC6_0009190 ⚠
Tetratricopeptide repeat, putative
— Both
TcYC6_0030670 ⚠
hypothetical protein, conserved
— Both
TcYC6_0114770 ⚠
putative intraflagellar transport protein 140
— Both
TcYC6_0121960 ⚠
ubiquitin-protein ligase, putative
— Both
TcYC6_0016180 ⚠
dynein heavy chain, putative
— OG7
TcYC6_0043480 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0048910 ⚠
5'-3' exoribonuclease B, putative
— OG7
TcYC6_0092100 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0055300 ⚠
WW domain containing protein, putative
— OG7
TcYC6_0095890 ⚠
ubiquitin-protein ligase
— OG7
TcYC6_0089660 ⚠
Guanine nucleotide exchange factor in Golgi t
— OG7
TcYC6_0126240 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0089530 ⚠
Sec7 domain containing protein, putative
— OG7
TcYC6_0081750 ⚠
dynein light chain p28, axonemal, putative
— OG7
TcYC6_0091660 ⚠
Phosphatidylinositol 3-kinase tor2
— Both
TcYC6_0016900 ⚠
putative phosphatidylinositol 3-kinase
— OG7
TcYC6_0095280 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0089970 ⚠
regulatory subunit of protein kinase a-like p
— OG7
TcYC6_0079240 ⚠
Axonemal inner arm dynein light chain, putati
— OG7
TcYC6_0109490 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0103200 ⚠
hypothetical protein
— OG7
TcYC6_0066360 ⚠
structural maintenance of chromosome 3 protei
— OG7
TcYC6_0055850 ⚠
Component of motile flagella 6
— OG7
TcYC6_0099570 ⚠
ubiquitin-protein ligase-like, putative
— Both
TcYC6_0014030 ⚠
Translation initiation factor eIF-2B subunit
— Both
TcYC6_0078830 ⚠
hypothetical protein, conserved
— Both
TcYC6_0119510 ⚠
General negative regulator of transcription s
— Both
TcYC6_0109300
kinesin , putative
— OG6
TcYC6_0000420 ⚠
phosphatidylinositol kinase related protein,
— Both
TcYC6_0025000 ⚠
predicted tetratricopeptide repeat protein
— Both
TcYC6_0064470 ⚠
hypothetical protein, conserved
— Both
TcYC6_0043860 ⚠
3-methylcrotonoyl-CoA carboxylase beta subuni
— Both
TcYC6_0064370 ⚠
translation initiation factor 2b, delta subun
— Both
TcYC6_0094770 ⚠
hypothetical protein, conserved
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.