LAMA_000762400

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_146732 OG7: OG7_0002830 149 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 149 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000299400 ⚠
Phe-tRNA synthetase beta subunit B1 domain/B3
— OG7
LAMA_000104800 ⚠
Aminopeptidase I zinc metalloprotease (M18)/M
— OG7
LAMA_000186300 ⚠
tRNA synthetases class I (C) catalytic domain
— OG7
LAMA_000440900 ⚠
CAF1 family ribonuclease, putative
— OG7
LAMA_000370600 ⚠
CAF1 family ribonuclease, putative
— OG7
LAMA_000441000 ⚠
CAF1 family ribonuclease, putative
— OG7
LAMA_000790000 ⚠
CAF1 family ribonuclease, putative
— OG7
LAMA_000381200 ⚠
Mitochondrial branched-chain alpha-ketoacid d
— OG7
LAMA_000454100 ⚠
Mitochondrial branched-chain alpha-ketoacid d
— OG7
LAMA_000406400 ⚠
OB-fold nucleic acid binding domain/tRNA synt
— OG7
LAMA_000474600 ⚠
Tubulin folding cofactor D C terminal, putati
— OG7
LAMA_000590700 ⚠
OB-fold nucleic acid binding domain/tRNA synt
— OG7
LAMA_000747000 ⚠
Glutaminyl-tRNA synthetase, non-specific RNA
— OG7
LAMA_000416700 ⚠
ATP synthase, putative
— OG7
LAMA_000775500 ⚠
ApbE family/Alanine dehydrogenase/PNT, C-term
— OG7
LAMA_000778900 ⚠
FAD dependent oxidoreductase/Pyridine nucleot
— OG7
LAMA_000096200 ⚠
Pyridine nucleotide-disulphide oxidoreductase
— OG7
LAMA_000448200 ⚠
Domain of unknown function (DUF1899)/Type of
— OG7
LAMA_000304200 ⚠
FKBP-type peptidyl-prolyl cis-trans isomerase
— OG7
LAMA_000031800 ⚠
Hsp70 protein, putative
— OG7
LAMA_000317300 ⚠
hypothetical protein, conserved
— OG7
LAMA_000337200 ⚠
hypothetical protein, conserved
— OG7
LAMA_000542900 ⚠
hypothetical protein, conserved
— OG7
LAMA_000313100 ⚠
Leucine-rich repeat, putative
— OG7
LAMA_000564700 ⚠
short chain dehydrogenase/Enoyl-(Acyl carrier
— OG7
LAMA_000090600 ⚠
hypothetical protein, conserved
— OG7
LAMA_000813600 ⚠
Hsp70 protein, putative
— OG7
LAMA_000298700 ⚠
FKBP-type peptidyl-prolyl cis-trans isomerase
— OG7
LAMA_000128600 ⚠
Metallopeptidase family M24/FACT complex subu
— OG7
LAMA_000510500 ⚠
Hsp70 protein, putative
— OG7
LAMA_000016500 ⚠
Conserved hypothetical protein 95/Ribosomal p
— OG7
LAMA_000520200 ⚠
hypothetical protein, conserved
— OG7
LAMA_000720600 ⚠
Histidine kinase-, DNA gyrase B-, and HSP90-l
— +2 more OG7
LAMA_000739100 ⚠
Uracil phosphoribosyltransferase, putative
— OG7
LAMA_000120800 ⚠
Histidine kinase-, DNA gyrase B-, and HSP90-l
— +2 more OG7
LAMA_000307900 ⚠
FKBP-type peptidyl-prolyl cis-trans isomerase
— OG7
LAMA_000462000 ⚠
SacI homology domain/Protein of unknown funct
— OG7
LAMA_000437200 ⚠
short chain dehydrogenase/Enoyl-(Acyl carrier
— OG7
LAMA_000241700 ⚠
Ribosomal protein L11 methyltransferase (PrmA
— OG7
LAMA_000431800 ⚠
FKBP-type peptidyl-prolyl cis-trans isomerase
— OG7
LAMA_000046200 ⚠
Methyltransferase domain containing protein,
— OG7
LAMA_000168600 ⚠
hypothetical protein, conserved
— OG7
LAMA_000808900 ⚠
SacI homology domain containing protein, puta
— OG7
LAMA_000358900 ⚠
Adaptin N terminal region/non-SMC mitotic con
— OG7
LAMA_000495200 ⚠
Leucine-rich repeat, putative
— OG7
LAMA_000567600 ⚠
Hsp70 protein/MreB/Mbl protein, putative
— OG7
LAMA_000032800 ⚠
ThiF family, putative
— OG7
LAMA_000237000 ⚠
Endonuclease/Exonuclease/phosphatase family/R
— OG7
LAMA_000080200 ⚠
hypothetical protein, conserved
— OG7
LAMA_000741600 ⚠
hypothetical protein, conserved
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.