LAMA_000454100

Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_146742 OG7: OG7_0002830 157 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 157 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000440900 ⚠
CAF1 family ribonuclease, putative
— +1 more Both
LAMA_000370600 ⚠
CAF1 family ribonuclease, putative
— +1 more Both
LAMA_000441000 ⚠
CAF1 family ribonuclease, putative
— +1 more Both
LAMA_000186300 ⚠
tRNA synthetases class I (C) catalytic domain
— +1 more Both
LAMA_000474600 ⚠
Tubulin folding cofactor D C terminal, putati
— +1 more Both
LAMA_000747000 ⚠
Glutaminyl-tRNA synthetase, non-specific RNA
— +1 more Both
LAMA_000381200 ⚠
Mitochondrial branched-chain alpha-ketoacid d
— Both
LAMA_000790000 ⚠
CAF1 family ribonuclease, putative
— OG7
LAMA_000762400 ⚠
Histidine kinase-, DNA gyrase B-, and HSP90-l
— OG7
LAMA_000104800 ⚠
Aminopeptidase I zinc metalloprotease (M18)/M
— Both
LAMA_000406400 ⚠
OB-fold nucleic acid binding domain/tRNA synt
— OG7
LAMA_000590700 ⚠
OB-fold nucleic acid binding domain/tRNA synt
— OG7
LAMA_000299400 ⚠
Phe-tRNA synthetase beta subunit B1 domain/B3
— +1 more Both
LAMA_000777800 ⚠
hypothetical protein, conserved
— Both
LAMA_000154800 ⚠
hypothetical protein, conserved
— OG7
LAMA_000543000 ⚠
hypothetical protein, conserved
— Both
LAMA_000153900 ⚠
PPPDE putative peptidase domain containing pr
— Both
LAMA_000801700 ⚠
FYVE zinc finger containing protein, putative
— Both
LAMA_000643700 ⚠
hypothetical protein, conserved
— Both
LAMA_000460200 ⚠
PPPDE putative peptidase domain containing pr
— Both
LAMA_000097900 ⚠
Domain of unknown function (DUF3437), putativ
— Both
LAMA_000473300 ⚠
WD domain, G-beta repeat/PFU (PLAA family ubi
— Both
LAMA_000283700 ⚠
Hydantoinase/oxoprolinase N-terminal region/H
— Both
LAMA_000721900 ⚠
M17 aminopeptidase N-terminal domain 2/Cytoso
— OG7
LAMA_000050100 ⚠
MORN repeat, putative
— OG7
LAMA_000073300 ⚠
MORN repeat, putative
— OG7
LAMA_000597100 ⚠
WW domain containing protein, putative
— OG7
LAMA_000595400 ⚠
HECT-domain (ubiquitin-transferase), putative
— OG7
LAMA_000090400 ⚠
HECT-domain (ubiquitin-transferase), putative
— OG7
LAMA_000820400 ⚠
SPRY domain/HECT-domain (ubiquitin-transferas
— OG7
LAMA_000307100 ⚠
Histidine phosphatase superfamily (branch 1),
— OG7
LAMA_000095800 ⚠
Histidine phosphatase superfamily (branch 1),
— OG7
LAMA_000095700 ⚠
6-phosphofructo-2-kinase, putative
— OG7
LAMA_000185800 ⚠
Ubiquitin carboxyl-terminal hydrolase, putati
— OG7
LAMA_000790700 ⚠
Ubiquitin carboxyl-terminal hydrolase, putati
— OG7
LAMA_000542000 ⚠
Ubiquitin carboxyl-terminal hydrolase, putati
— OG7
LAMA_000196700 ⚠
Domain of unknown function (DUF4200), putativ
— OG7
LAMA_000279000 ⚠
Zn-finger in Ran binding protein and others/F
— OG7
LAMA_000515800 ⚠
MORN repeat/FYVE zinc finger containing prote
— OG7
LAMA_000158500 ⚠
MORN repeat, putative
— OG7
LAMA_000667600 ⚠
PPPDE putative peptidase domain containing pr
— OG7
LAMA_000809200 ⚠
FYVE zinc finger containing protein, putative
— OG7
LAMA_000608400 ⚠
hypothetical protein, conserved
— OG7
LAMA_000744300 ⚠
hypothetical protein, conserved
— OG7
LAMA_000461700 ⚠
hypothetical protein, conserved
— OG7
LAMA_000165200 ⚠
FKBP-type peptidyl-prolyl cis-trans isomerase
— OG7
LAMA_000799800 ⚠
Leucine-rich repeat, putative
— OG7
LAMA_000286500 ⚠
Hsp70 protein, putative
— OG7
LAMA_000041600 ⚠
hypothetical protein, conserved
— OG7
LAMA_000115400 ⚠
Hsp70 protein/Tetratricopeptide repeat, putat
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.